Application of Metabolomics to Study Effects of Bariatric Surgery.

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Term Occurence Count Dictionary
type 2 diabetes mellitus 2 endocrinologydiseases
Insulin 1 endocrinologydiseasesdrugs
diabetes mellitus 2 endocrinologydiseases
niacin 1 endocrinologydiseasesdrugs
obesity 17 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 33430 no surgery)Pre- and postoperatively2015Arora, Tulika[[36]]UntargetedGC-MS and UPLC-MSHumanPlasmaRYGB Insulin -resistant morbidly obese subjects, some with diabetes16 patientsPresurgery and 4 and 42 days after surgery2015Lopes,
niacin 20706 [[57]]. Also levels of mentioned cholesterol [[33], [35], [46]], l-carnitine [[7], [11], [26], [43]], and niacin or choline [[7], [25], [26], [32], [45]] can be linked to gut microbes [[58]]. Modesitt et al. linked
Select Disease Character Offset Disease Term Instance
diabetes mellitus 3508 Toward the end of the previous century, it was communicated that bariatric surgery can resolve type 2 diabetes mellitus . What is really interesting is that the remission of T2DM can occur very fast, even before the patients
diabetes mellitus 19936 Firmicutes, and the proportion of this phyla to each other has been already linked to obesity and type 2 diabetes mellitus [[53]–[56]]. Accordingly, alterations of compounds which can be linked to gut microbes and their modulations
obesity 604 it continues to evolve and, by the same token, gives new or better possibilities to treat not only obesity but also associated comorbidities. Metabolomics is also a relatively young science discipline, and similarly,
obesity 1691 suggest new directions of surgery technics modifications, contribute to broadening knowledge about obesity and diseases related to it, and perhaps develop nonsurgical methods of treatment in the future.1. IntroductionBased
obesity 4577 demand [[1], [8], [9]]. Therefore, bariatric surgery has become the most effective treatment of morbid obesity and associated comorbidities, such as sleep apnea, hypertension, dyslipidaemia, and type 2 diabetes
obesity 13053 (omental adipose tissue) was performed by García-Alonso et al. [[50]].Most of the studies were focused on obesity , including morbid obesity, and type 2 diabetes. Interestingly, in one research, another disease, that
obesity 13079 performed by García-Alonso et al. [[50]].Most of the studies were focused on obesity, including morbid obesity , and type 2 diabetes. Interestingly, in one research, another disease, that is, nonalcoholic fatty liver
obesity 19917 Bacteroidetes and the Firmicutes, and the proportion of this phyla to each other has been already linked to obesity and type 2 diabetes mellitus [[53]–[56]]. Accordingly, alterations of compounds which can be linked
obesity 22305 Bankoglu et al. [[13]]. Alterations in the concentration of these compounds indicate the association of obesity with increased oxidative stress and DNA damage. Moreover, it was said that RYGB or caloric restriction
obesity 23597 group. Calvo et al. observed that the presence of moderate NAFLD is common in young patients with morbid obesity . Their data may be useful to explain the dissociation between excess lipid storage in adipose tissue,
obesity 28788 can suggest new directions for surgery technique modifications, contribute to broaden knowledge about obesity and related diseases, and perhaps develop nonsurgical methods of treatment in the future.Figure 1Summary
obesity 30453 T2DM419 individuals (38 obese and diabetic after RYGB and 381 diabetic and nondiabetic with overweight or obesity )Baseline, 1 year after RYGB2016Narath, Sophie H.[[32]]UntargetedLC-HRMS, HILICHumanSerumRYGBObesity44
obesity 31903 omental WAT from obese patients12 obese individuals after bariatric surgery and 10 patients without obesity after laparoscopic cholecystectomySurgery versus controls2016Bankoglu, Ezgi Eyluel[[13]]Targeted (8-oxoGua,
obesity 32256 17 sham surgery0 and 27 days2016Stratmann, B.[[49]]Targeted (lipoproteins)1H NMRHumanSerumDJBLMorbid obesity and T2DM18 subjects, finally 16; lipidome for 10 patientsNMR lipidomics baseline and 12 months2016Luo,
obesity 33279 C.[[7]]UntargetedGC-MS and UPLC-MS/MSHuman (women only)SerumLRYGB, LSG, LGB, open RYGBEndometrial histology, obesity 71 (41 LRYGB, 17 LSG, 8 LGB, 2 open RYGB, 3 no surgery)Pre- and postoperatively2015Arora, Tulika[[36]]UntargetedGC-MS
obesity 34515 postoperatively2014Kaska, Lukasz[[52]]Targeted (FA)GC-MSHumanSerumAnalysis before the surgeryMorbid obesity , nondiabetic16 womenSamples from the day of surgery2014Jüllig, Mia[[27]]UntargetedGC-MSHumanPlasmaGB,
obesity 34819 after surgery2014Heffron, Sean P.[[46]]TargetedNMR spectroscopyHumanFasting blood samplesLGBObesity and obesity -relatedcomorbidity50 obese patients, 47 with completed follow-upBaseline and 1, 2, 3, 4, and 5 years
obesity 35480 RYGB, 14 sham-operated8 weeks postoperation2012Oberbach, Andreas[[41]]TargetedLC-MSHumanSerumLSGMorbid obesity (children)6 obese childrenPre- and 6 months postoperatively2012Friedrich, Nele[[39]]Untargeted and targeted1H
obesity 36043 controls, samples six month after treatment2010Calvani, R.[[47]]Untargeted1H NMRHumanUrineBPD, RYGBMorbid obesity (insulin resistant)15 obese subjects, 10 matched controls in general, 2 subjects after bariatric surgery30
type 2 diabetes mellitus 3501 procedures. Toward the end of the previous century, it was communicated that bariatric surgery can resolve type 2 diabetes mellitus . What is really interesting is that the remission of T2DM can occur very fast, even before the patients
type 2 diabetes mellitus 19929 the Firmicutes, and the proportion of this phyla to each other has been already linked to obesity and type 2 diabetes mellitus [[53]–[56]]. Accordingly, alterations of compounds which can be linked to gut microbes and their modulations

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