Chronic Hepatitis C Association with Diabetes Mellitus and Cardiovascular Risk in the Era of DAA Therapy

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
hypertriglyceridemia 2 endocrinologydiseases
hypoglycemia 2 endocrinologydiseases
hypolipoproteinemia 1 endocrinologydiseases
type 2 diabetes mellitus 1 endocrinologydiseases
diabetic retinopathy 1 endocrinologydiseases
hyperlipidemia 1 endocrinologydiseases
diabetes mellitus 6 endocrinologydiseases
metabolic syndrome 2 endocrinologydiseases
Fluvastatin 1 endocrinologydiseasesdrugs
Insulin 3 endocrinologydiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Fluvastatin 15921 chronic HCV infection (aHR: 0,60, 95%CI 0,53-0,68). This effect was time-dependent, and Rosuvastatin and Fluvastatin showed the best efficacy [[53]]. After all, there is no knowledge about how statins do influence atherogenesis
Insulin 4252 possible implications of the DAA therapy on cardio- and cerebrovascular risk.2. Chronic HCV Infection, Insulin Resistance, and T2DMChronic HCV infection can lead to increased insulin resistance as hepatitis C virus
Insulin 8534 lead to a drop in the prevalence of T2DM in patients with chronic HCV infection in the near future. Insulin resistance leads to a worse therapeutic response to insulin therapy in patients with chronic HCV infection
Insulin 9482 study from Spain followed 1 059 patients with chronic HCV infection treated with interferon therapy. Insulin resistance was a negative predictive factor for SVR achievement. SVR achievement (OR: 0.44; 95%CI: 0.20-0.97;
Select Disease Character Offset Disease Term Instance
diabetes mellitus 554 /2018Publication date (epub): 8/2018AbstractPatients with chronic hepatitis C have both higher prevalence of diabetes mellitus type 2 (T2DM) and increased cardiovascular risk compared to never infected people. Sustained viral response
diabetes mellitus 10500 consideration the limitation represented by a very low number of patients followed in this study [[34]].New diabetes mellitus treatment options discovered recently could improve glycemic and metabolic profile and cardiovascular
diabetes mellitus 19343 the effect of DAA on fasting glucose or HbA1C followed patients with both chronic HCV infection and diabetes mellitus . Post hoc analysis of 6 studies that followed patients in 3a stage of chronic hepatitis C, genotype
diabetes mellitus 19681 in the study had normal glycemia levels, 25.4% of patients had prediabetes, and 5.9% of patients had diabetes mellitus . There was a significant drop in fasting glucose in the group of patients who received treatment compared
diabetes mellitus 26465 [59], [61], [63], [65], [66]].All of the previously mentioned findings confirmed better compensation of diabetes mellitus in patients who are treated with DAA. Majority of studies included patients treated with therapeutic
diabetes mellitus 34399 [[66]]USAGeneral population, 31% HIV positive, 17%T2DMGenotype 1Multiple DAANANo3%NA: not available; T2DM: type 2 diabetes mellitus .Table 2Studies reporting the changes of lipoprotein metabolism after DAA treatment.AuthorCountryGenotypeTreatmentIncrease
diabetic retinopathy 7999 decompensation of liver cirrhosis (RR: 2.01; 95% CI: 1.07-3.79; p<0.001) [[26]]. Interestingly, the incidence of diabetic retinopathy in patients with liver cirrhosis is significantly lower in HCV positive than in HCV negative patients
hyperlipidemia 14763 lipoprotein metabolism and accelerated atherogenesis in chronic HCV patients is needed [[48]].Although hyperlipidemia with chronic hepatitis C is a rare finding, patients could benefit from statin therapy, while they have
hypertriglyceridemia 29699 received placebo. The most significant drop was observed in the group of patients who had presented with hypertriglyceridemia before the therapy. In contrast to that, there was a small, but still significant, increase in hypertriglyceridemia
hypertriglyceridemia 29815 hypertriglyceridemia before the therapy. In contrast to that, there was a small, but still significant, increase in hypertriglyceridemia in the group of patients presenting with normal triglycerides levels before the therapy [[54]]. The
hypoglycemia 25461 patients with failure to achieve SVR [[57]].One of the severe complications of T2DM during DAA therapy is hypoglycemia . Spanish authors published case report of a well-compensated diabetic patient before sofosbuvir + ledipasvir
hypoglycemia 25889 dose was reduced. Despite that, on the 18th day of the therapy, the patient presented with symptomatic hypoglycemia with glucose level 50 mg/dL. On the 21st day of the therapy, bolus insulin was discontinued, and later
hypolipoproteinemia 16990 cardio-cerebrovascular risk [[6]]. The question that we are still looking for the answer to is whether hypolipoproteinemia mentioned in the previous chapter could have a protective effect on atherogenesis (see Figure 1).Atherosclerosis
metabolic syndrome 4695 cytokines (SOC-3), and (iv) induction of SOC-7 [[11]–[13]]. Even in HCV infected patients without metabolic syndrome , not only liver, but also whole-body insulin sensitivity is impaired. It is assumed that HCV infected
metabolic syndrome 13869 [44]].Infected patients do not have atherogenic dyslipidemia. This fact is the reason why the incidence of metabolic syndrome is, after sex, gender, and fibrosis stage adjustment, not higher in infected patients than in healthy
type 2 diabetes mellitus 34392 [[66]]USAGeneral population, 31% HIV positive, 17%T2DMGenotype 1Multiple DAANANo3%NA: not available; T2DM: type 2 diabetes mellitus .Table 2Studies reporting the changes of lipoprotein metabolism after DAA treatment.AuthorCountryGenotypeTreatmentIncrease

You must be authorized to submit a review.