Effectiveness of Omega-3 fatty acid for polycystic ovary syndrome: a systematic review and meta-analysis.

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Term Occurence Count Dictionary
hyperandrogenism 3 endocrinologydiseases
hyperinsulinemia 2 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases
obesity 2 endocrinologydiseases
polycystic ovary syndrome 3 endocrinologydiseases
testosterone 10 endocrinologydiseasesdrugs
Insulin 1 endocrinologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
Insulin 15295 95% CI -0.89, − 0.71; P<0. 00001)] (Fig. 3).Fig. 3The Change of Homeostasis Model Assessment of Insulin ResistanceFive RCTs [[8], [17], [19], [25], [27]] reported total cholesterol. We used fix effect model.
testosterone 5486 lipoprotein cholesterol (HDL-C), follicle stimulating hormone (FSH), luteotropic hormone (LH), total testosterone , sex hormone-binding globulin (SHBG)S (Study type)Randomized controlled trials (RCTs), which assess
testosterone 12213 LH26.9 ± 5.926.9 ± 5.031.46 ± 5.7431.88 ± 3.8612 weeksNadjarzadeh 2013 [[26]]3939Omega-3 fatty acids 900 mgParaffin oil (placebo) 3000 mgTotal testosterone , SHGB26.9 ± 5.926.9 ± 5.031.46 ± 5.7431.88 ± 3.8612 weeksRahmani 2017 [[19]]3434Omega-3
testosterone 12663 1000 mg + vitamin E 400 IUPlacebosBMI, SHGB, fasting insulin, fasting glucose, the change of HOMA, total testosterone 23.8 ± 4.625.2 ± 5.228.0 ± 4.328.5 ± 6.612 weeksKhani 2017 [[8]]4344Omega-3 fatty acids
testosterone 13149 1000 mg + Metformin 500 mgBMI, TG, TC, LDL-C, HDL-C, fasting insulin, fasting glucose, the change of HOMA, total testosterone , SHBG, adverse events28.4 ± 6.427.0 ± 3.226.9 ± 5.126.7 ± 5.312 weeksJamilian 2018
testosterone 18093 -2.16, 4.81; P = 0. 46) (Fig. 11).Fig. 10LDL-CFig. 11HDL-CFig. 12FSHFig. 13LHFig. 14SHGBFig. 15Total testosterone Only two RCTs [[19], [26]] reported FSH and LH, and three RCTs [[19], [20], [27]] reported SHGB and total
testosterone 18211 two RCTs [[19], [26]] reported FSH and LH, and three RCTs [[19], [20], [27]] reported SHGB and total testosterone . For FSH, LH and SHBG, we used fix effect model; while for total testosterone, due to the heterogeneity
testosterone 18289 reported SHGB and total testosterone. For FSH, LH and SHBG, we used fix effect model; while for total testosterone , due to the heterogeneity (Tau2 = 0.02, I2 = 45%, P = 0.16), we used random effect model. However,
testosterone 18741 -0.17; 95% CI -1.68, 1.33; P = 0. 82); SHGB: (WMD 0.55; 95% CI -7.07, 8.17; P = 0. 89); total testosterone : (WMD -0.08; 95% CI -0.29, 0.13; P = 0.49)] (Figs. 12, 13, 14 and 15).Adverse eventsOnly one study
testosterone 19437 omega-3 fatty acid has an effect on BMI, fasting insulin, fasting glucose, HDL-C, FSH, LH, SHGB and total testosterone . As PCOS is closely associated with insulin resistance and hyperandrogenism [[29]–[31]], based on
testosterone 20105 omega-3 fatty acid has an effect on BMI, fasting insulin, fasting glucose, HDL-C, FSH, LH, SHGB and total testosterone , it does not mean there is no medical significance. Instead, it may mean that omega-3 fatty acid may
Select Disease Character Offset Disease Term Instance
hyperandrogenism 19509 HDL-C, FSH, LH, SHGB and total testosterone. As PCOS is closely associated with insulin resistance and hyperandrogenism [[29]–[31]], based on current evidence, omega-3 fatty acid may be recommended for the treatment of
hyperandrogenism 20864 endocrine disorders that women suffer from [[34]], which is closely related to insulin resistance and hyperandrogenism [[4]–[6]]. The relationship between insulin resistance and hyperandrogenism is that insulin resistance
hyperandrogenism 20942 insulin resistance and hyperandrogenism [[4]–[6]]. The relationship between insulin resistance and hyperandrogenism is that insulin resistance can stimulate the production and secretion of androgens and ovarian failure
hyperinsulinemia 2691 supplement may be used for improving excessive oxidative stress-caused folliculogenesis disorder and hyperinsulinemia in women with PCOS [[10]–[12]]. Omega-3 fatty acids supplementation also has a beneficial effect on
hyperinsulinemia 17054 compared with the control group, there is not strong evidence that the omega-3 fatty acid has an effect on hyperinsulinemia because there was no statistical difference (WMD -8.28; 95% CI -24.35, 7.79; P = 0. 31) (Fig. 8).
metabolic syndrome 1820 lifestyle factors contribute significantly to the development of the PCOS [[4]]. The prevalence of metabolic syndrome (Reproductive disorders, infertility, metabolic disorders) in PCOS patients is higher than that in the
obesity 1646 associated with a variety of factors, including menstrual irregularity, insulin resistance, diabetes, and obesity [[3]]. The pathogenesis of PCOS is not yet clear, but genetics and lifestyle factors contribute significantly
obesity 2172 to undeniable pressure.The recommended treatments for PCOS women, especially for PCOS patients with obesity , are lifestyle and nutrition interventions and weight loss [[6], [7]]. The current study shows that
polycystic ovary syndrome 92 Title: Reproductive Biology and Endocrinology : RB&EEffectiveness of Omega-3 fatty acid for polycystic ovary syndrome : a systematic review and meta-analysisKailin YangLiuting ZengTingting BaoJinwen GePublication date (epub):
polycystic ovary syndrome 4749 inception to January, 2018. The search terms included omega-3 fatty acid, ω-3 fatty acid, n-3 fatty acid, polycystic ovary syndrome , PCOS.Studies meeting the inclusion criteria were included in this review (see Table 1).Table 1Inclusion
polycystic ovary syndrome 4931 included in this review (see Table 1).Table 1Inclusion criteriaP (Participants)Women with a diagnosis of polycystic ovary syndrome I (Intervention)Omega-3 fatty acid with no limits on the type, dose, frequency and so onC (Comparisons)Blanks,

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