Mild cognitive impairment and progression to dementia in people with diabetes, prediabetes and metabolic syndrome: a systematic review and meta-analysis

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Term Occurence Count Dictionary
diabetic retinopathy 1 endocrinologydiseases
hypertriglyceridemia 1 endocrinologydiseases
metabolic syndrome 7 endocrinologydiseases
obesity 7 endocrinologydiseases
type 2 diabetes mellitus 1 endocrinologydiseases
diabetes mellitus 1 endocrinologydiseases

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diabetes mellitus 18881 hypertension) and raised fasting plasma glucose level (≥ 100 mg/dL or previously diagnosed type 2 diabetes mellitus )Quality of included studiesMost of the studies were of moderate to high quality based on the criteria
diabetic retinopathy 24744 CI 0.90–0.96). Patients with diabetes who converted from MCI to dementia were more likely to have diabetic retinopathy and had reported more episodes of severe hypoglycaemia.In patients with MetS, high blood glucose levels
hypertriglyceridemia 6622 definitions for the MetS based on five cardiovascular risk factors that include abdominal obesity, hypertriglyceridemia , low high-density lipoprotein (HDL) levels, hypertension, and hyperglycaemia [[24]]. In research studies,
metabolic syndrome 148 EpidemiologyMild cognitive impairment and progression to dementia in people with diabetes, prediabetes and metabolic syndrome : a systematic review and meta-analysisKingshuk PalNaaheed MukadamIrene PetersenClaudia CooperPublication
metabolic syndrome 4555 [[8]]. This review focuses on the subset of potentially modifiable risks in people with MCI and diabetes/ metabolic syndrome to identify potential targets to reduce conversion from MCI to dementia in this higher risk population.Disturbances
metabolic syndrome 4715 conversion from MCI to dementia in this higher risk population.Disturbances of glycaemic control and metabolic syndrome as risk factors for disorders of cognitionType 2 diabetes (T2D) has been associated with a modest increased
metabolic syndrome 6260 rising, estimated as 35% in the UK and USA and up to 50% in China [[22]]. Associated with this is the metabolic syndrome (MetS)—a collection of cardiovascular risk factors that has been associated with an increased risk
metabolic syndrome 15144 flow diagram of studyTable 1Summary of included studiesStudyCountryRecruitmentClinic/communityDiabetes/ metabolic syndrome Duration of FUPOutcomesQuality score (/10)Artero [[49]]FranceRandom sample recruited from French electoral
metabolic syndrome 20700 pooled odds ratios of risk of progression from MCI to dementia in people with diabetes, prediabetes or metabolic syndrome Fig. 3Subgroup analysis comparing pooled odds ratios of risk of progression from MCI to dementia in people
metabolic syndrome 20843 comparing pooled odds ratios of risk of progression from MCI to dementia in people with diabetes and metabolic syndrome Type of dementiaFour studies provided a breakdown of the type of dementia diagnosed when participants
obesity 6613 different definitions for the MetS based on five cardiovascular risk factors that include abdominal obesity , hypertriglyceridemia, low high-density lipoprotein (HDL) levels, hypertension, and hyperglycaemia [[24]].
obesity 17903 1987CommunityDiabetes9 yearsAll cause dementia6aMetS diagnosis: ATPIII criteria—3 or more of the following components abdominal obesity (waist circumference > 102 cm for men and > 88 cm for women); elevated plasma triglycerides
obesity 18299 plasma glucose (≥ 110 mg/dL)bMetS diagnosis: International Diabetes Federation criteria—central obesity (waist circumference ≥ 90 cm for men and ≥ 80 cm for women) plus at least 2 CVRFs, including
obesity 22439 and MetS compared to 17.49 (95% CI 4.37–69.92) for people with hypertension without MetS.Central obesity Similar to the results above, the adjusted HR for central obesity was nearly three times higher, without
obesity 22505 hypertension without MetS.Central obesity Similar to the results above, the adjusted HR for central obesity was nearly three times higher, without reaching statistical significance (adjusted HR 2.97 with a 95%
obesity 23400 and therefore looked at the impact of having three or more risk factors out of hypertension, central obesity , dyslipidaemia and hyperglycaemia. People with three or more risk factors were nearly five times more
obesity 27308 dementia. The highest rates of incident dementia were associated with raised triglycerides, abdominal obesity and hypertension, with lower rates associated with low HDL cholesterol and raised blood glucose levels.
type 2 diabetes mellitus 18874 diagnosed hypertension) and raised fasting plasma glucose level (≥ 100 mg/dL or previously diagnosed type 2 diabetes mellitus )Quality of included studiesMost of the studies were of moderate to high quality based on the criteria

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