Extracellular Vesicles: A Novel Target for Exercise-Mediated Reductions in Type 2 Diabetes and Cardiovascular Disease Risk

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Term Occurence Count Dictionary
hyperglycemia 4 endocrinologydiseases
obesity 4 endocrinologydiseases
Insulin 1 endocrinologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
Insulin 2697 hyperglycemia are considered critical drivers of CVD that are linked together by insulin resistance [[5]]. Insulin resistance can be defined as the reduced responsiveness of skeletal muscle, liver, adipose, and vasculature
Select Disease Character Offset Disease Term Instance
hyperglycemia 814 (CVD) risk. However, only about 40–50% of this CVD risk reduction is accounted for by adiposity, hyperglycemia , hypertension, and dyslipidemia. Herein, we present the novel hypothesis that extracellular vesicles
hyperglycemia 2590 mortality [[4]]. As such, it is not surprising that elevated blood pressure and dyslipidemia in people with hyperglycemia are considered critical drivers of CVD that are linked together by insulin resistance [[5]]. Insulin
hyperglycemia 7036 particular, proinflammatory stimuli (e.g., oxidative stress/cytokines), bioactive lipids [[22]], and hyperglycemia [[23]] are considered key stimuli that impact EV release, phenotype, and function. In particular, hyperglycemia
hyperglycemia 7148 hyperglycemia [[23]] are considered key stimuli that impact EV release, phenotype, and function. In particular, hyperglycemia increases endothelium-derived EV formation, size, and reduces surface charge that collectively prompt
obesity 1047 candidate biomarkers that may relate to impaired endothelial function and insulin resistance independent of obesity risk factors. EVs are small membrane-bound particles that are generated by cells following stimulation,
obesity 4488 facilitate communication between cells. How EVs regulate vascular health remains to be fully determined, but obesity -related insulin resistance might be a potential reason through oxidative stress and inflammatory-related
obesity 8884 [9]] as well as hypertension [[30]], chronic kidney disease [[31]], and heart failure [[32]]. Even obesity , independent of comorbidities, presents with elevated platelet EV levels [[33]] in relation to reduced
obesity 34703 diabetes and cardiovascular disease but also regulate vascular function independent of traditional obesity -related risk factors. Future work should consider studying the interaction of EV and exercise doses

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