Recent Advances in the Development of Vaccines for Diabetes, Hypertension, and Atherosclerosis

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Term Occurence Count Dictionary
familial hypercholesterolemia 1 endocrinologydiseases
hyperglycemia 3 endocrinologydiseases
obesity 6 endocrinologydiseases
type 1 diabetes mellitus 1 endocrinologydiseases
type 2 diabetes mellitus 2 endocrinologydiseases
diabetes mellitus 5 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
diabetes mellitus 1486 vaccines used in protection against common metabolic diseases including atherosclerosis, hypertension, and diabetes mellitus .1. IntroductionOver the past decades, the lifespan of a human being increased significantly; however,
diabetes mellitus 3267 metabolic disease has made a great progress, especially in the treatment of dyslipidemia, atherosclerosis, diabetes mellitus , and hypertension.1.1. AtherosclerosisAtherosclerosis is classically defined as a chronic inflammation
diabetes mellitus 11529 metabolic diseases characterized by chronic hyperglycemia. The common forms of diabetes are type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). T1DM developed due to profound β cell destruction by autoimmune
diabetes mellitus 11565 chronic hyperglycemia. The common forms of diabetes are type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). T1DM developed due to profound β cell destruction by autoimmune attacks against pancreatic
diabetes mellitus 16383 well-tolerated and effective vaccine in T1DM [[60]].1.2.2. Vaccines against T2DMThe pathophysiology of type 2 diabetes mellitus remains unknown, but recent studies have strongly suggested obesity as a risk factor for T2DM [[61]].
familial hypercholesterolemia 881 humanized monoclonal antibodies have been successfully used for the treatment of neoplastic disorders or familial hypercholesterolemia . Humanized monoclonal antibody therapy needs repeated injection, and the therapy is expensive. Therapeutic
hyperglycemia 11474 Diabetes MellitusDiabetes mellitus is a group of chronic metabolic diseases characterized by chronic hyperglycemia . The common forms of diabetes are type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM).
hyperglycemia 15891 target for T1DM. Li et al. designed a vaccine, D41-IA2(5)-P2-1, which exhibited a significant control of hyperglycemia in NOD mice [[58]]. Another chimeric vaccine named as U-IA-2(5)-P2–1 (UIP-1) was designed by Li et
hyperglycemia 19196 United Kingdom Guidelines have well-defined guidelines for vaccination in diabetes. Resulting from hyperglycemia , diabetes patients are likely to suffer from diabetic complications in their elder ages. ATRQβ-001
obesity 11843 insulin-resistant state with decompensated β cell function commonly due to an unhealthy lifestyle and overweight/ obesity . In 2013, there are approximately 382 million patients suffering from diabetes; this number may increase
obesity 16461 pathophysiology of type 2 diabetes mellitus remains unknown, but recent studies have strongly suggested obesity as a risk factor for T2DM [[61]]. According to the American Diabetes Association (ADA) “Standards
obesity 16601 [[61]]. According to the American Diabetes Association (ADA) “Standards of Medical Care in Diabetes,” obesity management can delay the progression from prediabetes to T2DM and may be beneficial in the treatment
obesity 16785 beneficial in the treatment of T2DM [[62]]. Diet and physical exercise are the main ways to attain the obesity management; however, lifestyle manifestation fails to continue lifelong for some patients; therefore,
obesity 16922 lifestyle manifestation fails to continue lifelong for some patients; therefore, many patients consider anti obesity vaccines as an alternative choice. There are mainly 4 targets for obesity vaccines now, including adipose
obesity 16996 many patients consider antiobesity vaccines as an alternative choice. There are mainly 4 targets for obesity vaccines now, including adipose tissue antigens, somatostatin, glucose-dependent insulinotropic polypeptide
type 1 diabetes mellitus 11522 chronic metabolic diseases characterized by chronic hyperglycemia. The common forms of diabetes are type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). T1DM developed due to profound β cell destruction by autoimmune
type 2 diabetes mellitus 11558 characterized by chronic hyperglycemia. The common forms of diabetes are type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). T1DM developed due to profound β cell destruction by autoimmune attacks against pancreatic
type 2 diabetes mellitus 16376 well-tolerated and effective vaccine in T1DM [[60]].1.2.2. Vaccines against T2DMThe pathophysiology of type 2 diabetes mellitus remains unknown, but recent studies have strongly suggested obesity as a risk factor for T2DM [[61]].

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