Molecular Mechanisms Underlying Curcumin-Mediated Therapeutic Effects in Type 2 Diabetes and Cancer.

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Term Occurence Count Dictionary
rosiglitazone 2 endocrinologydiseasesdrugs
diabetes mellitus 2 endocrinologydiseases
endometrial carcinoma 1 endocrinologydiseases
glucose intolerance 1 endocrinologydiseases
obesity 6 endocrinologydiseases
type 2 diabetes mellitus 1 endocrinologydiseases
hyperglycemia 7 endocrinologydiseases
hyperlipidemia 2 endocrinologydiseases
metformin 1 endocrinologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
metformin 40641 advanced or metastatic breast cancer (NCT00852332; n = 100), (iv) gemcitabine along with paclitaxel and metformin in patients with unresectable pancreatic cancer (NCT02336087; n = 21), and (v) irinotecan in patients
rosiglitazone 24019 was associated with decreased body weight or fat composition in HFD-fed mice [[18], [22], [39]]. As rosiglitazone is the antihyperglycemic drug that acts through the activation of peroxisome proliferator-activated
rosiglitazone 50813 and FFAs tendency--| adipokine-induced angiogenesis[[33]]Sprague Dawley rats on HFDCUR (80 mg/kg), rosiglitazone (1 mg/kg), and their combination for 15 days↓ TNFα, lipolysis↓ serum, TC, TGs, LDL-C, FFAs, FBG,
Select Disease Character Offset Disease Term Instance
diabetes mellitus 794 /2018Publication date (epub): 3/2018AbstractThe growing prevalence of age-related diseases, especially type 2 diabetes mellitus (T2DM) and cancer, has become global health and economic problems. Due to multifactorial nature of both
diabetes mellitus 2318 anticancer activities of CUR that are responsible for its beneficial health effects.1. IntroductionType 2 diabetes mellitus (T2DM) and cancer are growing at epidemic proportions resulting in significant economic, social, and
endometrial carcinoma 37479 TGFβ/ERK signaling pathways (in the MDA-MB-231 cell line) [[68], [69]]. CUR also downregulated MMP2/9 in endometrial carcinoma cells via suppressing the ERK signaling pathway [[70]]. Recently, the novel antimetastatic mechanism
glucose intolerance 25016 been confirmed in high-fructose-fed Wistar rats, where CUR treatment attenuates insulin resistance and glucose intolerance as a consequence of its antioxidative and anti-inflammatory actions [[29]].The beneficial effects of
hyperglycemia 7070 effects of CUR.2. Curcumin and T2DMT2DM is a chronic, multifactorial, metabolic disorder characterized by hyperglycemia as a consequence of insulin deficiency (caused by decreased β-cell mass and the dysfunction of existing
hyperglycemia 8854 retinopathy, nephropathy, neuropathy, and cardiomyopathy, with the pathogenesis generally linked to hyperglycemia -induced oxidative stress and inflammation. As an overview of the molecular mechanisms targeted by CUR
hyperglycemia 13398 of CUR against the oxidative damage has been proven. In animals with experimental T2DM, CUR impaired hyperglycemia -induced oxidative stress through the normalization of the activity of hepatic antioxidant enzymes such
hyperglycemia 25238 CUR have also been observed in other diabetic animal models such as KK-Ay mice, in which CUR reduced hyperglycemia through PPARγ activation [[42]], and C57BL/KsJ-db/db mice, in which CUR reduced insulin resistance
hyperglycemia 25356 through PPARγ activation [[42]], and C57BL/KsJ-db/db mice, in which CUR reduced insulin resistance and hyperglycemia as a result of the increased blood insulin concentration that subsequently leads to enhanced glycolysis
hyperglycemia 25609 liver and augmented LPL activity in skeletal muscle [[17]]. Of note, CUR was also able to reduce a hyperglycemia -induced oxidative stress in erythrocytes and the liver of db/db mice, pointing to its protective role
hyperglycemia 46284 preclinical studies indicates that CUR possesses a number of antidiabetic health benefits via attenuating hyperglycemia , hyperlipidemia, and insulin resistance. These positive effects of CUR appear to predominantly result
hyperlipidemia 14244 expenditure, where glucose or lipids is/are used for energy production.It has been becoming clear that hyperlipidemia , reflected by chronically increased plasma FFAs, leads to an increased uptake of FFAs by the muscle
hyperlipidemia 46299 indicates that CUR possesses a number of antidiabetic health benefits via attenuating hyperglycemia, hyperlipidemia , and insulin resistance. These positive effects of CUR appear to predominantly result from its pleiotropic
obesity 2495 resulting in significant economic, social, and health burden. Moreover, there is increasing incidence of obesity that is associated with an increased risk of developing T2DM and cancer [[1]]. Despite many efforts,
obesity 7885 The current evidence clearly indicates that weight loss as a result of lifestyle, pharmaceutical, and obesity surgical interventions reduces the risk of developing T2DM in the long term by approximately 32%, 10–74%,
obesity 8104 63%, respectively [[13]]. Although the pathophysiological mechanisms engaged in the progression of obesity to T2DM are complex and not completely understood, elevated plasma free fatty acids (FFAs), stemming
obesity 19745 reducing NF-κB nuclear translocation in adipocytes [[31]].It is well established that the development of obesity -related diseases is a result of the expansion of adipose tissue and the formation of new blood vessels
obesity 20384 hypothesis that blocking adipose tissue angiogenesis with CUR is a successful strategy for the therapy of obesity -related diseases has been proven by some studies. In fact, CUR inhibits adipose tissue neovascularization
obesity 23269 last decade, antidiabetic properties of CUR have been extensively studied in various animal models of obesity (genetically and diet-induced) and T2DM (Table 1). The ability of this compound to improve glycemic
type 2 diabetes mellitus 787 /2018Publication date (epub): 3/2018AbstractThe growing prevalence of age-related diseases, especially type 2 diabetes mellitus (T2DM) and cancer, has become global health and economic problems. Due to multifactorial nature of both

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