In the View of Endothelial Microparticles: Novel Perspectives for Diagnostic and Pharmacological Management of Cardiovascular Risk during Diabetes Distress.

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Term Occurence Count Dictionary
hyperglycemia 3 endocrinologydiseases
metabolic syndrome 2 endocrinologydiseases
simvastatin 1 endocrinologydiseasesdrugs
type 1 diabetes mellitus 1 endocrinologydiseases
diabetes mellitus 2 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
simvastatin 17790 peroxidation in endothelial cells rather than hypotensive effects [[59]–[61]]. Similarly, statins such as simvastatin and fluvastatin, as well as vitamin C and losartan, reduced the circulating levels of EMPs in hypertensive
Select Disease Character Offset Disease Term Instance
diabetes mellitus 22033 macrophage infiltration↑ Cardiac inflammationDD-T2DM patients (distressed depressive patients with type-2 diabetes mellitus ); AS-T1DM rats (acutely stressed rats with type 1 diabetes mellitus); CS-DS/obese rats (chronically
diabetes mellitus 22101 depressive patients with type-2 diabetes mellitus); AS-T1DM rats (acutely stressed rats with type 1 diabetes mellitus ); CS-DS/obese rats (chronically stressed rats with metabolic syndrome); HbA1C (glycosylated hemoglobin);
hyperglycemia 5781 corticosterone peaks induced by diabetes-related stressors also enhance diabetic insulin resistance and hyperglycemia , which contribute to the progression of diabetes [[30]]. For these reasons, diabetes distress is also
hyperglycemia 8458 pointing at diabetes distress as the major cause of cardiovascular complications underlying chronic hyperglycemia in stressed diabetic subjects [[8]].Accordingly, distressed diabetic patients have a 1.69-fold higher
hyperglycemia 14642 although high glucose levels did not change EMPs' morphology (i.e., size and antigen composition), the hyperglycemia increases the functionality of EMPs in activating NADPH oxidase/p38phox-mediated signaling when compared
metabolic syndrome 10757 agreement with these findings, Matsuura et al. [[20]] showed that the chronic exposure of animals with metabolic syndrome (DahlS.Z-Leprfa/Leprfa/obese rats) to restraint stress exacerbates the preexisting hypertension, ventricular
metabolic syndrome 22170 (acutely stressed rats with type 1 diabetes mellitus); CS-DS/obese rats (chronically stressed rats with metabolic syndrome ); HbA1C (glycosylated hemoglobin); LDL-c (low-density lipoprotein-cholesterol); H2O2 (hydrogen peroxide);
type 1 diabetes mellitus 22094 (distressed depressive patients with type-2 diabetes mellitus); AS-T1DM rats (acutely stressed rats with type 1 diabetes mellitus ); CS-DS/obese rats (chronically stressed rats with metabolic syndrome); HbA1C (glycosylated hemoglobin);

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