Leukemic arthritis and severe hypercalcemia in a man with chronic myeloid leukemia: a case report and review of the literature

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calcitriol 1 endocrinologydiseasesdrugs
dexamethasone 4 endocrinologydiseasesdrugs
hypercalcemia 29 endocrinologydiseases
hyperparathyroidism 1 endocrinologydiseases
primary hyperparathyroidism 1 endocrinologydiseases
zoledronic acid 1 endocrinologydiseasesdrugs

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calcitriol 12236 co-existing in patients with CML [[18]]. A reported cause of humoral-mediated hypercalcemia in CML is a calcitriol -related mechanism [[19]]. As our patient had normal parathyroid levels, we could exclude PHPT. Although
dexamethasone 1687 hypercalcemia was refractory. We therefore decided to prescribe 20 mg/day of intravenously administered dexamethasone ; fortunately, his serum calcium level decreased dramatically to normal range within a few days.ConclusionsAlthough
dexamethasone 8651 response in his high serum calcium level, we decided to add 20 mg/day of intravenously administered dexamethasone on day 8 of admission. His severe headache symptom improved gradually, and the serum calcium level decreased
dexamethasone 15571 acidPonatinibCR in 5 days; died 8 months laterThis case (2018)35/M1 yearBPHydration, calcitonin, dexamethasone ImatinibCR in 1 week from dexamethasone; later, lost to follow-upAP accelerated phase, BP blast phase,
dexamethasone 15611 8 months laterThis case (2018)35/M1 yearBPHydration, calcitonin, dexamethasoneImatinibCR in 1 week from dexamethasone ; later, lost to follow-upAP accelerated phase, BP blast phase, BU busulfan, CML chronic myeloid leukemia,
zoledronic acid 15460 [[18]]70/MNRBPParathyroidectomyImatinibNRToro-Tobón et al. (2017) [[4]]58/M6 yearsBPHydration, calcitonin, zoledronic acid PonatinibCR in 5 days; died 8 months laterThis case (2018)35/M1 yearBPHydration, calcitonin, dexamethasoneImatinibCR
Select Disease Character Offset Disease Term Instance
hypercalcemia 68 Title: Journal of Medical Case ReportsLeukemic arthritis and severe hypercalcemia in a man with chronic myeloid leukemia: a case report and review of the literaturePongprueth RujirachunApichaya
hypercalcemia 542 typically present with high white blood cell counts revealed during annual checkups. Leukemic arthritis and hypercalcemia are rare manifestations in patients with chronic myeloid leukemia.Case presentationA 35-year-old Thai
hypercalcemia 1203 600 mg of imatinib once daily before switching to 140 mg of dasatinib. He subsequently developed severe hypercalcemia (total serum calcium of 17.8 mg/dL), with generalized osteolytic lesions detected on a bone survey.
hypercalcemia 1582 administered hydration, intravenously administered calcitonin, and 600 mg/day of imatinib, the severe hypercalcemia was refractory. We therefore decided to prescribe 20 mg/day of intravenously administered dexamethasone;
hypercalcemia 1846 decreased dramatically to normal range within a few days.ConclusionsAlthough leukemic arthritis and severe hypercalcemia are extraordinary presentations in patients with chronic myeloid leukemia, the advanced phase of the
hypercalcemia 2055 of the disease might bring on these symptoms. Apart from parathyroid hormone-related protein-related hypercalcemia , vitamin D is a mechanism of humoral-mediated hypercalcemia.Electronic supplementary materialThe online
hypercalcemia 2115 parathyroid hormone-related protein-related hypercalcemia, vitamin D is a mechanism of humoral-mediated hypercalcemia .Electronic supplementary materialThe online version of this article (10.1186/s13256-018-1798-5) contains
hypercalcemia 2901 lung, CA of the breast, and CA of the esophagus [[3]]. Previous studies have reported an incidence of hypercalcemia of approximately 2.5% for all types of leukemia [[4]]. Hypercalcemia in patients with CML is very rare,
hypercalcemia 3240 patient with CML who developed these two uncommon manifestations (LA followed by severe symptomatic hypercalcemia ) and an extensive review of the related literature.Case presentationA 35-year-old Thai man was diagnosed
hypercalcemia 10014 with CML with rare coexistence manifestations: leukemic oligoarthritis and, subsequently, symptomatic hypercalcemia .From a previous study, LA is a very rare complication of both adult and chronic leukemia; however, acute
hypercalcemia 11088 and his symptoms were improved after a 7 + 3 induction regimen plus high-dose imatinib.CML with hypercalcemia was first reported in 1970 [[9]]. In hypercalcemic patients with CML, osteolytic bone can present with
hypercalcemia 11819 previous studies have reported normal serum PTHrP levels, but PTHrP involvement in the pathogenesis of hypercalcemia could not be excluded since paracrine inducing osteoclastic activity directly to bone is possible [[15]–[17]].
hypercalcemia 11981 osteoclastic activity directly to bone is possible [[15]–[17]]. For the treatment of PTHrP-related hypercalcemia , imatinib is the most effective medication [[14]]. Another proposed humoral-mediated hypercalcemia is
hypercalcemia 12080 hypercalcemia, imatinib is the most effective medication [[14]]. Another proposed humoral-mediated hypercalcemia is primary hyperparathyroidism (PHPT) co-existing in patients with CML [[18]]. A reported cause of humoral-mediated
hypercalcemia 12210 hyperparathyroidism (PHPT) co-existing in patients with CML [[18]]. A reported cause of humoral-mediated hypercalcemia in CML is a calcitriol-related mechanism [[19]]. As our patient had normal parathyroid levels, we could
hypercalcemia 12787 within a few days of intravenous corticosteroid administration. We propose that vitamin D-mediated hypercalcemia was probably the mechanism for hypercalcemia in this patient, even if the active form of vitamin D was
hypercalcemia 12832 corticosteroid administration. We propose that vitamin D-mediated hypercalcemia was probably the mechanism for hypercalcemia in this patient, even if the active form of vitamin D was not tested. Table 1 presents the previously
hypercalcemia 12990 vitamin D was not tested. Table 1 presents the previously reported cases of patients with CML with hypercalcemia , showing the treatment and clinical outcomes for each patient.Table 1Reported cases of chronic myeloid
hypercalcemia 13121 treatment and clinical outcomes for each patient.Table 1Reported cases of chronic myeloid leukemia with hypercalcemia AuthorsAge/SexOnset of hypercalcemia after CML diagnosisPhase of CMLTreatmentResultsNon-chemotherapyChemotherapyBallard
hypercalcemia 13157 patient.Table 1Reported cases of chronic myeloid leukemia with hypercalcemiaAuthorsAge/SexOnset of hypercalcemia after CML diagnosisPhase of CMLTreatmentResultsNon-chemotherapyChemotherapyBallard and Marcus (1970)
hypercalcemia 15979 not reported, PRED prednisolone, VCR vincristine, 6MP 6-mercaptopurineTurning to another mechanism of hypercalcemia , local bone destruction resulting from leukemic cell infiltration can explain the elevated serum calcium
hypercalcemia 16181 elevated serum calcium levels in patients with CML [[4]]. This has been proposed as the main mechanism of hypercalcemia when all humoral markers have been excluded. However, we have found that even if serum humoral markers
hypercalcemia 16340 However, we have found that even if serum humoral markers are normal or decreased, humoral-mediated hypercalcemia cannot be totally excluded. Here, we demonstrated the case of a patient with CML blast phase presenting
hypercalcemia 16477 excluded. Here, we demonstrated the case of a patient with CML blast phase presenting with LA and severe hypercalcemia , which are two exceptional manifestations. Taking all into account, we believe that vitamin D-mediated
hypercalcemia 16594 which are two exceptional manifestations. Taking all into account, we believe that vitamin D-mediated hypercalcemia is a component of the humoral-mediated hypercalcemia mechanisms in patients with CML.ConclusionsAlthough
hypercalcemia 16647 into account, we believe that vitamin D-mediated hypercalcemia is a component of the humoral-mediated hypercalcemia mechanisms in patients with CML.ConclusionsAlthough LA and severe hypercalcemia are extraordinary presentations
hypercalcemia 16727 the humoral-mediated hypercalcemia mechanisms in patients with CML.ConclusionsAlthough LA and severe hypercalcemia are extraordinary presentations in patients with CML, the advanced phase of the disease might produce
hypercalcemia 16884 with CML, the advanced phase of the disease might produce these symptoms. Apart from PTHrP-related hypercalcemia , vitamin D is a mechanism of humoral-mediated hypercalcemia.Additional fileAdditional file 1:Timeline
hypercalcemia 16944 these symptoms. Apart from PTHrP-related hypercalcemia, vitamin D is a mechanism of humoral-mediated hypercalcemia .Additional fileAdditional file 1:Timeline table of the patient. (DOCX 16 kb
hyperparathyroidism 12105 is the most effective medication [[14]]. Another proposed humoral-mediated hypercalcemia is primary hyperparathyroidism (PHPT) co-existing in patients with CML [[18]]. A reported cause of humoral-mediated hypercalcemia in
primary hyperparathyroidism 12097 imatinib is the most effective medication [[14]]. Another proposed humoral-mediated hypercalcemia is primary hyperparathyroidism (PHPT) co-existing in patients with CML [[18]]. A reported cause of humoral-mediated hypercalcemia in

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