Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses.

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
diabetes mellitus 5 endocrinologydiseases
metabolic syndrome 4 endocrinologydiseases
obesity 8 endocrinologydiseases
polycystic ovary syndrome 2 endocrinologydiseases
type 2 diabetes mellitus 3 endocrinologydiseases

There are not enough annotations found in this document to create the proximity graph.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
diabetes mellitus 39 Title: PLoS ONERisk factors for type 2 diabetes mellitus : An exposure-wide umbrella review of meta-analysesAlternative Title: Risk factors for T2DMVanesa Bellou
diabetes mellitus 1269 UNITED STATESPublication date (epub): 3/2018Publication date (collection): /2018AbstractBackgroundType 2 diabetes mellitus (T2DM) is a global epidemic associated with increased health expenditure, and low quality of life. Many
diabetes mellitus 3200 AvailabilityAll relevant data are within the paper and its Supporting Information files.BackgroundType 2 diabetes mellitus (T2DM) ranks highly on the international health agenda as a global pandemic and as a threat to human
diabetes mellitus 13648 <10−6.10.1371/journal.pone.0194127.t001Table 1Characteristics of 142 associations between non-genetic risk factors and type 2 diabetes mellitus .ReferenceRisk factorLevel of comparisonNumber of cases/controlsNumber of datasetsEffect size metricRandom-effects
diabetes mellitus 40064 study.10.1371/journal.pone.0194127.t003Table 3Characteristics of mendelian randomization studies for type 2 diabetes mellitus .ReferenceExposureLevel of comparisonGenetic instrumentN of SNPs in instrumentN casesEffect size metricCausal
metabolic syndrome 2776 and some medical conditions (high systolic blood pressure, late menarche age, gestational diabetes, metabolic syndrome , preterm birth) presented robust evidence for increased risk of T2DM.ConclusionsA healthy lifestyle
metabolic syndrome 35691 level of serum gamma-glutamyl transferase (highest vs. lowest category, and per 1 log unit increase), metabolic syndrome , increased time of television watching, low hip circumference, late age at menarche, weight gain in
metabolic syndrome 48888 [[36]]Several medical conditions have been traditionally linked to increased risk for T2DM. Patients with metabolic syndrome and gestational diabetes presented higher risk for T2DM. The seven-fold increase of risk for developing
metabolic syndrome 50197 manifestation of ongoing low-grade hepatic inflammation or hepatocellular damage, which is common in T2DM and metabolic syndrome . Among hepatic enzymes, ALT is the most specific indicator of hepatic pathology in non-alcoholic fatty
obesity 30015 (2.33–3.68)2.80 × 10−201.11–7.7690.6No/NoHighly suggestiveBell, 2014 [[120]]Metabolically healthy obesity Metabolically healthy obese vs. metabolically healthy non-obese1285/26,19610RR4.40 (2.83–6.84)4.97
obesity 30204 (2.83–6.84)4.97 × 10−111.29–14.9547.8No/NoConvincingBell, 2014 [[120]]Metabolically healthy obesity Metabolically unhealthy obese vs. metabolically healthy non-obese1266/24,6688RR9.50 (7.48–12.08)8.79
obesity 34702 and excess significance bias) for risk of T2DM. Low whole grains consumption, metabolically healthy obesity , increased sedentary time, low adherence to a healthy dietary pattern, high level of serum uric acid,
obesity 35510 processed meat consumption, high level of total and leisure-time physical activity, metabolically unhealthy obesity , psoriasis, low coffee consumption, high systolic blood pressure, high level of serum gamma-glutamyl
obesity 46499 recently published MR study [[29]].Most of the associations yielded from our analyses were proxies of obesity and include body mass index (BMI), weight gain, and anthropometric characteristics (i.e., hip circumference,
obesity 48229 be explained by the correlation of this personality trait with physical inactivity and high risk for obesity . [[35]] Our analysis also indicated that there is highly suggestive evidence for the association of
obesity 52146 association between smoking and T2DM has biological foundation because smoking is associated with central obesity and increased oxidative stress and inflammation, and eventually leads to insulin resistance and hyperglycaemia.
obesity 55743 healthy lifestyle and dietary pattern combined with interventions against the increased incidence of obesity could alleviate the projections for an increase of T2DM incidence in near future. However, these findings
polycystic ovary syndrome 11946 childhood experience, height, hip circumference, serum osteocalcin, spousal diabetes, osteoarthritis, polycystic ovary syndrome , schizophrenia, major depressive disorder, and bipolar disorder), combined cross-sectional studies with
polycystic ovary syndrome 33773 not available, NO2: nitrogen dioxide, OR: odds ratio, PAI-1: plasminogen activator inhibitor-1, PCOS: polycystic ovary syndrome , PM2,5: particulate matter with a diameter of 2,5 μm or less, PM10: particulate matter with a diameter
type 2 diabetes mellitus 32 Title: PLoS ONERisk factors for type 2 diabetes mellitus : An exposure-wide umbrella review of meta-analysesAlternative Title: Risk factors for T2DMVanesa Bellou
type 2 diabetes mellitus 13641 <10−6.10.1371/journal.pone.0194127.t001Table 1Characteristics of 142 associations between non-genetic risk factors and type 2 diabetes mellitus .ReferenceRisk factorLevel of comparisonNumber of cases/controlsNumber of datasetsEffect size metricRandom-effects
type 2 diabetes mellitus 40057 study.10.1371/journal.pone.0194127.t003Table 3Characteristics of mendelian randomization studies for type 2 diabetes mellitus .ReferenceExposureLevel of comparisonGenetic instrumentN of SNPs in instrumentN casesEffect size metricCausal

You must be authorized to submit a review.