Neurofibromatosis type 1-associated multiple rectal neuroendocrine tumors: A case report and review of the literature

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osteoporosis 1 endocrinologydiseases
sunitinib 1 endocrinologydiseasesdrugs
carcinoid 2 endocrinologydiseases
everolimus 1 endocrinologydiseasesdrugs
neuroendocrine tumor 31 endocrinologydiseases

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everolimus 14574 multiple interventions. For example, somatostatin analogs and molecular targeting drugs like sunitinib and everolimus inhibit tumor growth, are anti-angiogenic, and have been successfully applied in clinical applications.
sunitinib 14560 multidisciplinary and multiple interventions. For example, somatostatin analogs and molecular targeting drugs like sunitinib and everolimus inhibit tumor growth, are anti-angiogenic, and have been successfully applied in clinical
Select Disease Character Offset Disease Term Instance
carcinoid 14011 cancer suggested that endoscopic resection or endoscopic dissection was the first choice for rectal carcinoid s that had lower levels of malignancy with sizes of no more than 2 cm in the mucosal or submucosal layers.
carcinoid 15597 very high, and she should receive regular follow-ups every 3-6 mo.Table 1Summary of multiple rectal carcinoid case reportsCaseSexAgeNumberSize (mm)The depth of invasionLymph node metastasisHistological stageTreatmentComplicated
neuroendocrine tumor 92 Title: World Journal of GastroenterologyNeurofibromatosis type 1-associated multiple rectal neuroendocrine tumor s: A case report and review of the literatureRui XieDepartment of Gastroenterology, Affiliated Hospital
neuroendocrine tumor 1148 the central and peripheral nervous systems. However, rare cases of NF-1-associated multiple rectal neuroendocrine tumor s have been reported. This report describes a case of a 39 year old female with NF-1 and intermittent
neuroendocrine tumor 1677 the rectal submucosal layer. Histological and immunohistochemical results suggested multiple rectal neuroendocrine tumor s, a rare disease with few appreciable symptoms and a particularly poor prognosis. The patient with NF-1
neuroendocrine tumor 2373 peripheral nervous systems. However, there are rare reported cases of NF-1 associated with multiple rectal neuroendocrine tumor s. This study reports a case of a 39 year old female NF-1 patient with not only multiple rectal neuroendocrine
neuroendocrine tumor 3364 abnormalities, which may also result in peripheral neurilemmomas, central nervous system tumors, stromal tumors, neuroendocrine tumor s, and other benign and malignant tumors[[6]-[8]]. However, the incidence of NF-1 in combination with
neuroendocrine tumor 3503 and malignant tumors[[6]-[8]]. However, the incidence of NF-1 in combination with gastrointestinal neuroendocrine tumor is less than two percent. Neuroendocrine tumors are commonly found in the duodenum and pancreas[[9]-[12]]
neuroendocrine tumor 3696 the duodenum and pancreas[[9]-[12]] and usually present as a single malignant lesion. Multiple rectal neuroendocrine tumor s are particularly rare, with diverse and non-specific clinical symptoms. Common symptoms include changes
neuroendocrine tumor 4159 department has received and treated a patient diagnosed with NF-1 that was combined with multiple rectal neuroendocrine tumor s, vascular malformations, and scoliosis.CASE REPORTA 39 year old woman was admitted to our department
neuroendocrine tumor 7001 Syn (+), and TTF-1 (-), with a Ki-67 index of < 2%, thus supporting the diagnosis of a grade 1 rectal neuroendocrine tumor (Figure 4A-B). Specimens from many nodules were taken throughout the body and were examined by pathohistology
neuroendocrine tumor 7568 corresponded to a diagnosis of type I neurofibromatosis (Figure 4C-E). This patient had multiple rectal neuroendocrine tumor s with a diameter > 20 mm. The probability of lymph node metastasis and distant metastasis was considered
neuroendocrine tumor 8611 resonance imaging.Figure 3Imaging, endoscopy and endoscopy ultrasonographic findings of multiple rectal neuroendocrine tumor s in the patient. A and B: Magnetic resonance imaging (red dotted line marking the widest point of the
neuroendocrine tumor 8888 Endoscopic manifestations; E: Blood vessels were apparent on the surface of the nodules under the NBI ( neuroendocrine tumor s marked by the white arrow); F: Endoscopic ultrasonography of the multiple rectal neuroendocrine tumors
neuroendocrine tumor 8991 (neuroendocrine tumors marked by the white arrow); F: Endoscopic ultrasonography of the multiple rectal neuroendocrine tumor s (red dotted line marking the widest point of the tumors, measuring approximately 25.5 mm). NBI: Narrow-band
neuroendocrine tumor 9211 Narrow-band imaging.Figure 4Immunohistochemical results of skin neurofibromatosis and multiple rectal neuroendocrine tumor s. A: HE staining of multiple rectal neuroendocrine tumors (× 200); B: CgA staining pattern of multiple
neuroendocrine tumor 9268 skin neurofibromatosis and multiple rectal neuroendocrine tumors. A: HE staining of multiple rectal neuroendocrine tumor s (× 200); B: CgA staining pattern of multiple rectal neuroendocrine tumors (× 200); C: HE staining
neuroendocrine tumor 9343 staining of multiple rectal neuroendocrine tumors (× 200); B: CgA staining pattern of multiple rectal neuroendocrine tumor s (× 200); C: HE staining of the skin neurofibromatosis (× 200); D and E: S-100 and CD34 staining patterns
neuroendocrine tumor 11159 tract[[14]]. Clinical data confirmed that approximately two percent of patients diagnosed with NF-1 also have neuroendocrine tumor s, which may be related to Ras-PI3K over-activation that leads to an imbalance of rapamycin (mTOR) expression[[15]].
neuroendocrine tumor 11385 expression[[15]]. The case presented in this report contradicts previous studies claiming that complicated neuroendocrine tumor s are commonly located in the region around the ampulla of the duodenum and pancreas[[9]-[12]]. There
neuroendocrine tumor 11575 duodenum and pancreas[[9]-[12]]. There are very few cases of NF-1 that are associated with multiple rectal neuroendocrine tumor s. Rectal neuroendocrine neoplasms (NENs) are often derived from peptidergic neurons and neuroendocrine
neuroendocrine tumor 12120 ultrasound and biopsy are used as the main diagnostic methods for non-functional NENs.Clinically, the rectal neuroendocrine tumor s are mostly non-functional. In addition, rectal neuroendocrine tumors are usually single-onset, with
neuroendocrine tumor 12189 non-functional NENs.Clinically, the rectal neuroendocrine tumors are mostly non-functional. In addition, rectal neuroendocrine tumor s are usually single-onset, with only two to four percent being multiple-onset. Previous research suggests
neuroendocrine tumor 12331 single-onset, with only two to four percent being multiple-onset. Previous research suggests that the MEN1 ( neuroendocrine tumor ) gene, PI3-K/AKT, Raf/MEK/ERK, Notch, GSK-3β and other signaling pathways may be involved in the occurrence
neuroendocrine tumor 12662 past 20 years and found that only one case, combined with NF-1 in 14 cases, reports of multiple rectal neuroendocrine tumor s (Table 1)[[18]-[26]]. Moreover, compared with Ghassemi[[26]]’s case report in 2010, the number of
neuroendocrine tumor 14398 the malignant tendency and metastasis of most gastrointestinal NENs, in addition to surgery, rectal neuroendocrine tumor s require a combination of multidisciplinary and multiple interventions. For example, somatostatin analogs
neuroendocrine tumor 15308 confirmed, multidisciplinary and multi-system combination therapy is an inevitable trend in the treatment of neuroendocrine tumor s. However, the patient rejected surgery and so the pathological data are therefore not available in
neuroendocrine tumor 16422 Transmission electron microscope; SM: Submucosa; M3: Mina muscularismiucosae.In addition to rectal neuroendocrine tumor s, the patient also presented with malformations of the external iliac veins and the spinal column. A
neuroendocrine tumor 19524 patients. Although surgical and symptomatic treatments are currently preferred for multiple rectal neuroendocrine tumor s, patients often require multi-system and multi-disciplinary comprehensive treatment. It is necessary
neuroendocrine tumor 21186 T2 values.Pathological diagnosisPathohistological and immunohistochemical examinations showed that neuroendocrine tumor cells were present in the lesions and mutually linked to form cord, nest, or gland-like structures.
neuroendocrine tumor 22074 are commonly found in the duodenum and pancreas, and rare cases of NF-1-associated multiple rectal neuroendocrine tumor s have been reported. We have summarized the relevant literature in the past 20 years and found that
neuroendocrine tumor 22269 past 20 years and found that only one case, combined with NF-1 in 14 cases, reports of rectal multiple neuroendocrine tumor s. In addition, this is the first case where NF-1 is complicated by abdominal iliac vein malformation.Term
neuroendocrine tumor 23119 patients. Although surgical and symptomatic treatments are currently preferred for multiple rectal neuroendocrine tumor s, patients often require multi-system and multi-disciplinary comprehensive treatment
osteoporosis 18920 several factors, including the direct erosion of neurofibroma, dural dilatation of the spinal canal, osteoporosis , precocious puberty, and mesoderm dysplasia[[31],[32]]. Patients with scoliosis may also develop lung

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