Vitamin E Metabolic Effects and Genetic Variants: A Challenge for Precision Nutrition in Obesity and Associated Disturbances

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Term Occurence Count Dictionary
obesity 19 endocrinologydiseases
Tangier disease 1 endocrinologydiseases
ezetimibe 1 endocrinologydiseasesdrugs
hypertriglyceridemia 5 endocrinologydiseases
metabolic syndrome 5 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
ezetimibe 21730 obesity, body fat mass, and type 2 diabetes [[78]]. Furthermore, NPC1 is the pharmacological target of ezetimibe , which is an inhibitor of cholesterol endocytosis that is widely used for treatment of this dyslipidemia
Select Disease Character Offset Disease Term Instance
Tangier disease 23331 lipophilic compounds, mainly packaging them into HDL particles [[83]]. Evidence has been collected from Tangier disease ’s patients, who suffer from a deficiency of the ABCA1 gene and show an absence of serum HDL, hypertriglyceridemia,
hypertriglyceridemia 23442 disease’s patients, who suffer from a deficiency of the ABCA1 gene and show an absence of serum HDL, hypertriglyceridemia , and reduction in LDL serum levels. Impaired cholesterol and lipid transport functions result in the
hypertriglyceridemia 29700 allele A is associated with higher levels of HDL, and lower risks of visceral obesity, diabetes, and hypertriglyceridemia [[100]].Apo-AV constitutes a minor apolipoprotein that is almost exclusively expressed in liver, and
hypertriglyceridemia 30077 triglyceride regulation. Apo-AV is a potent regulator of triglyceridemia, and human deficiency leads to hypertriglyceridemia . This apolipoprotein participates in the assembly of VLDL, and is found in HDL and chylomicrons, but
hypertriglyceridemia 31857 with a great prevalence for metabolic syndrome, as it is accompanied by a higher prevalence of plasma hypertriglyceridemia [[109]] and greater α-tocopherol [[107],[110]]. In addition, GWA studies have provided details about
hypertriglyceridemia 32567 α-tocopherol [[113]]. The presence of the T/T genotype of rs5082 has been associated with postprandial hypertriglyceridemia response and greater cardiovascular risk compared with individuals carrying C/T or C/C allele combinations
metabolic syndrome 3899 obesity, cardiovascular disease (CAD), and metabolic-related diseases. Critical pathways involved in metabolic syndrome are under the influence of VE, and evidence suggests that in specific cases, adequate supplementation
metabolic syndrome 5783 [[18]] levels of plasma VE in comparison with normal weight subjects in different studies. People with metabolic syndrome (MetS) may show half of the plasma VE found in the reference group (i.e., 12.5 µmol/L versus 25.5 µmol/L),
metabolic syndrome 30767 variants associated with APOA5 in the modulation of lipid metabolism and an increased risk of obesity and metabolic syndrome (for reviews, see Guardiola et al. (2017) and Girona et al. (2018) [[105],[106]]). The most studied
metabolic syndrome 31783 or 56C>G). The G allele is very rare worldwide, and has been associated with a great prevalence for metabolic syndrome , as it is accompanied by a higher prevalence of plasma hypertriglyceridemia [[109]] and greater α-tocopherol
metabolic syndrome 50323 the transmembrane transport of cholesterol and lipoproteins. Thus, critical pathways in obesity and metabolic syndrome may be under the influence of VE, and variation in the genes involved in VE metabolism might be of relevance,
obesity 1194 conditions associated with disturbances in lipid metabolism or concomitant with oxidative stress, such as obesity . However, dietary reference values for VE in obese populations have not yet been defined, and VE supplementation
obesity 3798 [[5],[6],[7],[8],[9],[10],[11]]. Furthermore, some studies have outlined the relevance that VE and derivatives may have in obesity , cardiovascular disease (CAD), and metabolic-related diseases. Critical pathways involved in metabolic
obesity 4095 adequate supplementation would be an appropriate strategy to help in treatment of the prevention of obesity and its associated comorbidities [[12],[13]]. However, dietary reference values for VE in obese populations
obesity 8446 specifically analyzing those that could be particularly relevant in the prevention or treatment of obesity and its associated complications.2. Vitamin E Metabolism: An OverviewVE and its derivatives are present
obesity 12502 metabolic effects in order to define guidelines that are able to support more precise nutrition for obesity and related diseases. Strategies considering VE supplementation should take into account genetic variability
obesity 16512 testing [[60]]. Furthermore, although most of the CD36 polymorphisms are not strongly associated with obesity , they clearly contribute to interindividual variability in plasma lipid and lipoprotein profiles, therefore
obesity 20687 expected due to its main role as an HDL transporter. These situations can be worsened in the case of obesity , particularly if lower levels of plasma VE are found. Although more research is needed in order to discern
obesity 21348 mutations in the NPC1 gene have been associated with lysosomal storage disorders [[76]], and concerning obesity , a Genome Wide Association (GWA) study found a role for the non-synonymous variant rs1805081 (His215Arg)
obesity 21493 study found a role for the non-synonymous variant rs1805081 (His215Arg) in early-onset and morbid adult obesity in the European population [[77]], and follow-up studies have shown the involvement of common genetic
obesity 21627 [[77]], and follow-up studies have shown the involvement of common genetic variants in adult-onset obesity , body fat mass, and type 2 diabetes [[78]]. Furthermore, NPC1 is the pharmacological target of ezetimibe,
obesity 29677 Consequently, the presence of allele A is associated with higher levels of HDL, and lower risks of visceral obesity , diabetes, and hypertriglyceridemia [[100]].Apo-AV constitutes a minor apolipoprotein that is almost
obesity 30755 genetic variants associated with APOA5 in the modulation of lipid metabolism and an increased risk of obesity and metabolic syndrome (for reviews, see Guardiola et al. (2017) and Girona et al. (2018) [[105],[106]]).
obesity 45316 biological mechanisms dealing with oxidative stress conditions, low-grade inflammation as observed in obesity , and other factors contributing to the development of the atherogenic process could be influenced by
obesity 45656 the adverse effects of oxidative stress that are characteristic of cardiovascular diseases, such as obesity and atherosclerosis. However, taking into account recent findings, this may not be exclusively associated
obesity 48994 protects cells against oxidative stress [[160],[161]]. The decreased expression of SIRT1 is related to obesity [[162]] and genetic variants located in the SIRT1 gene have been associated with body mass index (BMI)
obesity 49109 and genetic variants located in the SIRT1 gene have been associated with body mass index (BMI) and obesity risk; specifically, a lower BMI has been observed in carriers of the minor alleles of rs7895833 (G)
obesity 49692 intake [[161]], suggesting the capacity of VE to modify the association between SIRT1 variants and obesity .4. Concluding RemarksVitamin E has a recognized leading role as a contributor to the protection of cell
obesity 50311 associated with the transmembrane transport of cholesterol and lipoproteins. Thus, critical pathways in obesity and metabolic syndrome may be under the influence of VE, and variation in the genes involved in VE metabolism
obesity 51066 effects of VE and the influence of genetic variants remains a challenge for precision nutrition in obesity and associated disturbances

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