Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans

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Term Occurence Count Dictionary
lipomatosis 2 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases
neuroendocrine tumor 1 endocrinologydiseases
type 2 diabetes mellitus 2 endocrinologydiseases
dexamethasone 1 endocrinologydiseasesdrugs
hyperinsulinemia 1 endocrinologydiseases
hyperlipidemia 5 endocrinologydiseases
hypertriglyceridemia 6 endocrinologydiseases
obesity 13 endocrinologydiseases
cortisol 5 endocrinologydiseasesdrugs
diabetes mellitus 2 endocrinologydiseases
hyperglycemia 1 endocrinologydiseases

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cortisol 23811 activation of glucocorticoids.61 Corticosterone is the major glucocorticoid in mice and rats, whereas cortisol is the major glucocorticoid in humans. Hamsters secrete both cortisol and corticosterone, and chronic
cortisol 23881 glucocorticoid in mice and rats, whereas cortisol is the major glucocorticoid in humans. Hamsters secrete both cortisol and corticosterone, and chronic stress increases cortisol.62 Immune suppression caused by cortisol may
cortisol 23939 glucocorticoid in humans. Hamsters secrete both cortisol and corticosterone, and chronic stress increases cortisol .62 Immune suppression caused by cortisol may also be involved in the pancreatic cancer susceptibility
cortisol 23980 cortisol and corticosterone, and chronic stress increases cortisol.62 Immune suppression caused by cortisol may also be involved in the pancreatic cancer susceptibility of hamsters.Clinical studies3.2Pancreatic
cortisol 31221 neurotrophic microenvironment created by FI may be involved in pancreatic cancer promotion. In obesity, cortisol secretion is increased by 11β‐HSD1 in adipocytes78 and may increase tumor development and metastasis
dexamethasone 13611 cells were shown to differentiate into adipocytes in an adipogenic differentiation medium containing dexamethasone , 3‐isobutyl‐1‐methylxanthine, insulin and indomethacin.43 Hyperinsulinemia in obesity/T2DM and
Select Disease Character Offset Disease Term Instance
diabetes mellitus 657 CenterTokyoJapanPublication date (epub): 9/2018Publication date (ppub): 10/2018AbstractObesity, type 2 diabetes mellitus (T2DM) and aging are associated with pancreatic cancer risk, but the mechanisms of pancreatic cancer
diabetes mellitus 4543 in both experimental animals and humans.Epidemiological studies have shown that obesity and type 2 diabetes mellitus (T2DM) are risk factors for pancreatic cancer.8 Obesity and T2DM accompany dyslipidemia and visceral
hyperglycemia 14909 increased in inflammatory cells in obese adipose tissue, and anti‐CD44 antibody treatment lowers hyperglycemia and improves insulin resistance, adipose inflammation, and hepatic steatosis in diet‐induced obese
hyperinsulinemia 20625 develop PDAC after treatment with BOP.39 These data indicated that T2DM with hypertriglyceridemia and/or hyperinsulinemia is not sufficient to increase susceptibility to pancreatic carcinogenesis. The pancreas of mice and
hyperlipidemia 10643 around large vessels (Figure 1E),2 similar to that seen in humans with severe pancreatic FI.18T2DM and hyperlipidemia models in mice and rats2.3.2In our study on colon carcinogenesis in T2DM model KK‐Ay mice,36 we found
hyperlipidemia 15755 polygenic in KK mice, and Suto et al51 reported quantitative trait loci (QTLs) that are responsible for hyperlipidemia in these mice. An apolipoprotein A‐II gene polymorphism was identified as the cause of cholesterol
hyperlipidemia 17609 treatment with BOP, a pancreatic carcinogen, enhance the severity (Table 1).2 Syrian golden hamsters have hyperlipidemia , and the hepatic lipoprotein lipase activity in Syrian golden hamsters is lower compared with that of
hyperlipidemia 20148 Wiley & Sons, LtdAnimal models of T2DM and hypertriglyceridemia3.1.2Initially, we hypothesized that hyperlipidemia and obesity might contribute to the susceptibility of hamsters to pancreatic cancer development, and
hyperlipidemia 20320 hamsters to pancreatic cancer development, and we then attempted to develop PDAC in mice and rats with hyperlipidemia /T2DM. In our preliminary study, ApcMin mice were treated with BOP, but did not develop PDAC (data not
hypertriglyceridemia 4053 cancer susceptibility and to develop preventive methods against them. Syrian golden hamsters develop hypertriglyceridemia and fatty infiltration (FI) of the pancreas, and the severity of FI increases along with the progression
hypertriglyceridemia 11446 mice.36ApcMin mice, a model of familial adenomatous polyposis, are insulin‐resistant and develop hypertriglyceridemia with age.38 Despite having high serum triglyceride levels, ApcMin mice are lean, and scattered intralobular
hypertriglyceridemia 11711 pancreas (data not shown).Otsuka Long‐Evans Tokushima Fatty (OLETF) rats, a T2DM model accompanied by hypertriglyceridemia , and their controls (Long‐Evans Tokushima Otsuka [LETO] rats) did not develop scattered intralobular
hypertriglyceridemia 15561 resistance.KK‐Ay mice, established by cross‐breeding diabetic KK mice with obese Ay mice, exhibit severe hypertriglyceridemia , which is derived from KK mice.36 Non‐insulin‐dependent T2DM is polygenic in KK mice, and Suto et al51
hypertriglyceridemia 20091 diet with the same age.†Modified from reference 2.John Wiley & Sons, LtdAnimal models of T2DM and hypertriglyceridemia 3.1.2Initially, we hypothesized that hyperlipidemia and obesity might contribute to the susceptibility
hypertriglyceridemia 20597 pancreas and failed to develop PDAC after treatment with BOP.39 These data indicated that T2DM with hypertriglyceridemia and/or hyperinsulinemia is not sufficient to increase susceptibility to pancreatic carcinogenesis. The
lipomatosis 9588 31 Human immunodeficiency virus‐1 infection and/or antiretroviral therapy are also known to cause lipomatosis .32Medications and alcohol2.2.3Steroid hormones and some chemical agents are involved in the development
lipomatosis 9771 are involved in the development of fatty pancreas.22 Antiretroviral therapy is also known to cause lipomatosis .32 Rosiglitazone has been shown to exacerbate pancreatic FI in C57BL/6 mice fed a high‐fat/high‐sucrose
metabolic syndrome 8962 associated with abdominal obesity, insulin resistance, T2DM, dyslipidemia, arterial hypertension and metabolic syndrome .26, 27 In non‐obese T2DM patients, a significant association between pancreatic steatosis and atherosclerosis
neuroendocrine tumor 27358 Non‐tumor areas of pancreatic tissue from surgical specimens of patients with well‐differentiated neuroendocrine tumor s (grade 1 or 2) were histologically analyzed for FI, fibrosis in intra‐ and extralobular locations,
obesity 4524 pancreatic carcinogenesis in both experimental animals and humans.Epidemiological studies have shown that obesity and type 2 diabetes mellitus (T2DM) are risk factors for pancreatic cancer.8 Obesity and T2DM accompany
obesity 7764 these factors increase the fat/parenchymal ratio in middle‐aged and elderly people.23 In the case of obesity , the parenchymal pancreas volume increases by approximately 10%‐15%, whereas pancreatic fat mass increases
obesity 8439 <50 years old, but increased progressively to age 60.24 These results suggest that the overweight/ obesity in middle‐aged men and the hypercholesterolemia in postmenopausal women may be involved in the development
obesity 8887 (2.28% vs 1.77%).25Fatty pancreas‐associated disease2.2.2Fatty pancreas is associated with abdominal obesity , insulin resistance, T2DM, dyslipidemia, arterial hypertension and metabolic syndrome.26, 27 In non‐obese
obesity 10977 interlobular fat that was mainly observed around large vessels. On the other hand, C57BL/6J‐Ay mice, an obesity model, had fewer intralobular adipocytes in the pancreas (Figure 1H) and ICR mice had only small adipocytes
obesity 13314 around large vessels in the pancreas, is widely observed in most species and seems to be associated with obesity /T2DM. Similarly, perivascular fat of the liver has been observed in fatty liver subjects.41 Perivascular
obesity 13709 containing dexamethasone, 3‐isobutyl‐1‐methylxanthine, insulin and indomethacin.43 Hyperinsulinemia in obesity /T2DM and stress‐induced glucocorticoid production may prompt the differentiation of perivascular mesenchymal
obesity 16172 As Yazdi et al54 reviewed, many gene mutations/single nucleotide polymorphisms are associated with obesity in mice/humans, and leptin‐melanocortin pathway‐related genes, in particular, are associated with
obesity 16292 mice/humans, and leptin‐melanocortin pathway‐related genes, in particular, are associated with monogenic obesity via food intake and energy expenditure. Some of these genes could also be involved in the development
obesity 16873 anti‐inflammatory cytokine, has a protective role in the development of NAFPD and that high‐fat diet‐induced obesity decreases IL‐10 synthesis ability of the spleen and aggravates fat accumulation and inflammatory responses
obesity 20167 LtdAnimal models of T2DM and hypertriglyceridemia3.1.2Initially, we hypothesized that hyperlipidemia and obesity might contribute to the susceptibility of hamsters to pancreatic cancer development, and we then attempted
obesity 25801 <.001).18 This result indicates that pancreatic FI is a possible risk factor for PDAC, independent of obesity and DM. In addition, severe fibrosis was often observed in the pancreatic tissue areas without FI in
obesity 31212 FI.77 A neurotrophic microenvironment created by FI may be involved in pancreatic cancer promotion. In obesity , cortisol secretion is increased by 11β‐HSD1 in adipocytes78 and may increase tumor development and
type 2 diabetes mellitus 650 Cancer CenterTokyoJapanPublication date (epub): 9/2018Publication date (ppub): 10/2018AbstractObesity, type 2 diabetes mellitus (T2DM) and aging are associated with pancreatic cancer risk, but the mechanisms of pancreatic cancer
type 2 diabetes mellitus 4536 carcinogenesis in both experimental animals and humans.Epidemiological studies have shown that obesity and type 2 diabetes mellitus (T2DM) are risk factors for pancreatic cancer.8 Obesity and T2DM accompany dyslipidemia and visceral

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