Fenofibrate monotherapy-induced rhabdomyolysis in a patient with hypothyroidism: A rare case report and literature review.

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Term Occurence Count Dictionary
fenofibrate 27 endocrinologydiseasesdrugs
hyperlipidemia 1 endocrinologydiseases
hypertriglyceridemia 7 endocrinologydiseases
hypothyroidism 5 endocrinologydiseases
prednisone 1 endocrinologydiseasesdrugs
cortisol 1 endocrinologydiseasesdrugs
diabetes mellitus 1 endocrinologydiseases

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Review

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Select Drug Character Offset Drug Term Instance
cortisol 3120 second admission, she had an endocrine test showing a marked decrease in basal hormone levels (i.e., cortisol , thyroid, and gonadal hormones). Her liver function, and renal function tests were within normal limits,
fenofibrate 759 intracellular muscle contents into the systemic circulation, which is the most serious and fatal side effect of fenofibrate . The objective of this paper is to discuss fatal side effect of fenofibrate and keep safe medication.Patient
fenofibrate 835 and fatal side effect of fenofibrate. The objective of this paper is to discuss fatal side effect of fenofibrate and keep safe medication.Patient concerns:A patient with hypothyroidism who presented with rhabdomyolysis
fenofibrate 960 medication.Patient concerns:A patient with hypothyroidism who presented with rhabdomyolysis during fenofibrate monotherapy for hypertriglyceridemia was reported.Diagnoses:Fenofibrate Monotherapy Induced Rhabdomyolysis.Interventions:Fenofibrate
fenofibrate 1391 were normal and the patient was good and discharged 2 weeks later.Lessons:13 cases associated with fenofibrate monotherapy-induced rhabdomyolysis were reviewed, which had been published in the English literature.
fenofibrate 1521 monotherapy-induced rhabdomyolysis were reviewed, which had been published in the English literature. The severity of fenofibrate muscle toxicity may be the result of the combination of two rhabdomyolysis enhancers, such as hypothyroidism
fenofibrate 2065 injury, muscle necrosis, and the release of muscle cell constituents into systemic circulation. While fenofibrate monotherapy-induced rhabdomyolysis is rare, it is a serious, even fatal side effect of fenofibrate[[1]]
fenofibrate 2164 fenofibrate monotherapy-induced rhabdomyolysis is rare, it is a serious, even fatal side effect of fenofibrate [[1]] that is often associated with acute renal failure (ARF) and myoglobinuria. Comorbidities, such
fenofibrate 2446 (DM), female gender, high dose, and advanced age (older than 65 years old) are major risk factors for fenofibrate -induced rhabdomyolysis.[[2]] We report the case of a patient with HTD who experienced rhabdomyolysis
fenofibrate 2568 rhabdomyolysis.[[2]] We report the case of a patient with HTD who experienced rhabdomyolysis while on fenofibrate monotherapy for hypertriglyceridemia.Case report2A 36-year-old sterile woman was admitted twice to the
fenofibrate 3453 hospital. The patient took prednisone, and levothyroxine, and had started to use 200 mg micronized fenofibrate a day for hypertriglyceridemia (triglyceride [TG] level of 10.72 mmol/L). After taking fenofibrate
fenofibrate 3554 fenofibrate a day for hypertriglyceridemia (triglyceride [TG] level of 10.72 mmol/L). After taking fenofibrate for 15 days, the patient complained of diffuse myalgia, and muscle weakness, which had not been alleviated
fenofibrate 4119 urea nitrogen (BUN) of 11.70 mmol/L, and blood myoglobin of greater than 500 ng/mL. A diagnosis of fenofibrate monotherapy-induced rhabdomyolysis and rhabdomyolysis-induced ARF was made. Because of the seriousness
fenofibrate 4311 Because of the seriousness of her side effects, and the fact that her TG level was within normal range, fenofibrate was discontinued. Adequate fluid resuscitation, mannitol diuresis, myocardium protection, hepatoprotection,
fenofibrate 4634 and Cr concentrations had declined to 2350 U/L and 106 μmol/L, respectively. After suspending fenofibrate , the blood test irregularities gradually improved. Two weeks after her second admission, the patient's
fenofibrate 5198 combination therapy in adults with hypertriglyceridemia and mixed dyslipidemia (DL).[[3]] Micronized fenofibrate is better absorbed than standard preparations, which allows for lower daily dosage and once daily administration.[[4]]
fenofibrate 5341 standard preparations, which allows for lower daily dosage and once daily administration.[[4]] In general, fenofibrate is well tolerated and side effects are fairly uncommon (e.g., gastrointestinal, and musculoskeletal
fenofibrate 5564 cutaneous reactions, fatigue, headache, vertigo, sleep disorders, and loss of libido).[[5]] However, fenofibrate monotherapy-induced rhabdomyolysis can occur.We report a new case of fenofibrate monotherapy-induced
fenofibrate 5645 libido).[[5]] However, fenofibrate monotherapy-induced rhabdomyolysis can occur.We report a new case of fenofibrate monotherapy-induced rhabdomyolysis. The patient was diagnosed with rhabdomyolysis based on myalgia,
fenofibrate 6154 disturbances, and ARF, the most common complication of rhabdomyolysis (10–40% of patients).[[7]] Because fenofibrate led to such serious side effects, and the patient's TG level was normal, then she discontinued fenofibrate,
fenofibrate 6261 fenofibrate led to such serious side effects, and the patient's TG level was normal, then she discontinued fenofibrate , and other hypolipidemic drugs, after which her TG levels remained satisfactory. Thus, one limitation
fenofibrate 6480 this case study lies in that it does not investigate the treatment of hyperlipidemia in patients with fenofibrate -induced rhabdomyolysis.For a more in-depth analysis, we searched for relevant studies in the English
fenofibrate 6716 PubMed, and Embase electronic databases from inception to August 1, 2016. The following terms were used: fenofibrate , fibrates, hypertriglyceridemia, and rhabdomyolysis. In addition, the reference lists of all accepted
fenofibrate 6918 all accepted papers were manually searched to ensure that no studies were ignored. Thirteen cases of fenofibrate monotherapy–associated rhabdomyolysis were found (Tables 1 and 2). Nevertheless, the cause of rhabdomyolysis
fenofibrate 7230 risk factors for muscle injury,[[6]] while one patient with HTD presented with rhabdomyolysis while on fenofibrate monotherapy for hypertriglyceridemia. Monotherapy-induced, and hypothyroid-associated rhabdomyolysis
fenofibrate 7590 in HTD remains unclear.[[8]]Table 1A summary of reported 13 cases of rhabodomyolysis associated with fenofibrate monotherapy.Table 2A summary of reported 13 cases of rhabodomyolysis associated with fenofibrate monotherapy.HTD
fenofibrate 7687 with fenofibrate monotherapy.Table 2A summary of reported 13 cases of rhabodomyolysis associated with fenofibrate monotherapy.HTD is associated with impairment of mitochondrial oxidative metabolism and many other metabolic
fenofibrate 8346 reported for thyroid hypofunction after craniotomy for pituitary adenoma. In her case, the severity of fenofibrate -induced muscle toxicity may have been the result of the combination of 2 confounding risk factors for
prednisone 3379 disease. Pituitary hypofunction was diagnosed, and she was admitted to our hospital. The patient took prednisone , and levothyroxine, and had started to use 200 mg micronized fenofibrate a day for hypertriglyceridemia
Select Disease Character Offset Disease Term Instance
diabetes mellitus 2326 failure (ARF) and myoglobinuria. Comorbidities, such as renal, or liver disease, hypothyroidism (HTD), diabetes mellitus (DM), female gender, high dose, and advanced age (older than 65 years old) are major risk factors for
hyperlipidemia 6448 satisfactory. Thus, one limitation of this case study lies in that it does not investigate the treatment of hyperlipidemia in patients with fenofibrate-induced rhabdomyolysis.For a more in-depth analysis, we searched for relevant
hypertriglyceridemia 498 (epub): 4/2018AbstractAbstractRationale:Fenofibrate is a fibric acid derivative indicated for use in hypertriglyceridemia and mixed dyslipidemia treatment among adults. Rhabdomyolysis is a syndrome characterized by muscle
hypertriglyceridemia 988 concerns:A patient with hypothyroidism who presented with rhabdomyolysis during fenofibrate monotherapy for hypertriglyceridemia was reported.Diagnoses:Fenofibrate Monotherapy Induced Rhabdomyolysis.Interventions:Fenofibrate was
hypertriglyceridemia 2596 the case of a patient with HTD who experienced rhabdomyolysis while on fenofibrate monotherapy for hypertriglyceridemia .Case report2A 36-year-old sterile woman was admitted twice to the hospital. Seventeen years prior to
hypertriglyceridemia 3475 took prednisone, and levothyroxine, and had started to use 200 mg micronized fenofibrate a day for hypertriglyceridemia (triglyceride [TG] level of 10.72 mmol/L). After taking fenofibrate for 15 days, the patient complained
hypertriglyceridemia 5132 range.Discussion3Fenofibrate is a fibric acid derivative indicated for use as mono- or combination therapy in adults with hypertriglyceridemia and mixed dyslipidemia (DL).[[3]] Micronized fenofibrate is better absorbed than standard preparations,
hypertriglyceridemia 6739 electronic databases from inception to August 1, 2016. The following terms were used: fenofibrate, fibrates, hypertriglyceridemia , and rhabdomyolysis. In addition, the reference lists of all accepted papers were manually searched
hypertriglyceridemia 7258 injury,[[6]] while one patient with HTD presented with rhabdomyolysis while on fenofibrate monotherapy for hypertriglyceridemia . Monotherapy-induced, and hypothyroid-associated rhabdomyolysis were rarely described, with only 3 cases
hypothyroidism 80 Title: MedicineFenofibrate monotherapy-induced rhabdomyolysis in a patient with hypothyroidism A rare case report and literature reviewDawei WangYanqiu Wang NA.aDepartment of Neurosurgery, the second
hypothyroidism 904 to discuss fatal side effect of fenofibrate and keep safe medication.Patient concerns:A patient with hypothyroidism who presented with rhabdomyolysis during fenofibrate monotherapy for hypertriglyceridemia was reported.Diagnoses:Fenofibrate
hypothyroidism 1627 fenofibrate muscle toxicity may be the result of the combination of two rhabdomyolysis enhancers, such as hypothyroidism and female gender. To avoid it, strict clinical and laboratory monitoring should be maintained, particularly
hypothyroidism 1751 female gender. To avoid it, strict clinical and laboratory monitoring should be maintained, particularly hypothyroidism . Patients should be informed of possible potentially irreversible effects after taking fibrates.Introduction1Rhabdomyolysis
hypothyroidism 2304 associated with acute renal failure (ARF) and myoglobinuria. Comorbidities, such as renal, or liver disease, hypothyroidism (HTD), diabetes mellitus (DM), female gender, high dose, and advanced age (older than 65 years old)

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