An aPPARent Functional Consequence in Skeletal Muscle Physiology via Peroxisome Proliferator-Activated Receptors.

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Term Occurence Count Dictionary
fenofibrate 3 rheumatologydiseasesdrugs
myopathy 4 rheumatologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
fenofibrate 6302 used as insulin sensitizers in order to improve insulin resistance in T2DM patients. Fibrates include fenofibrate , clofibrate, and ciprofibrate, which exhibit a predominant PPARα activity and induce lipid uptake and
fenofibrate 37808 the late 1960s [[125]]. The fibrates that are commonly used for clinical treatment are bezafibrate, fenofibrate , and gemfibrozil. Fenofibrate treatment in patients with metabolic syndrome improves lipid profiles
fenofibrate 38180 insulin sensitivity in insulin-deficient streptozotocin-treated mice [[128]]. However, bezafibrate and fenofibrate exhibit weak PPARβ/δ and/or PPARγ agonist activity [[125],[129]]. Therefore, the direct pharmacological
Select Disease Character Offset Disease Term Instance
myopathy 23485 mutations in the PNPLA2 gene, which encodes ATGL in humans, can lead to neutral lipid storage diseases with myopathy . In humans, ATGL is exclusively expressed in type I muscle fibers and plays an important role in skeletal
myopathy 41543 running endurance of these transgenic mice [[42]]. Furthermore, in the mouse model of ischemic cardio myopathy , the impaired exercise endurance following myocardial infarction could be reversed by the PPARβ/δ
myopathy 55312 normal aging process. Interestingly, the clinical use of fibrates may cause muscle weakness and pain ( myopathy ), or rhabdomyolysis in rare cases [[191]]. The exact mechanism of PPARα activation in diseased and
myopathy 58500 However, the widespread use of these ligands is plagued by their accompanying side effects. Beside myopathy , fibrates are also known to increase the risk for gallstones formation [[205]] and renal failure [[206]].

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