Radiations and female fertility

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Annotation Summary

Term Occurence Count Dictionary
hypogonadism 1 endocrinologydiseases
ovarian dysfunction 2 endocrinologydiseases
premature ovarian failure 3 endocrinologydiseases
Precocious puberty 1 endocrinologydiseases
cyclophosphamide 1 endocrinologydiseasesdrugs
hyperprolactinemia 1 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

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Review

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Select Drug Character Offset Drug Term Instance
cyclophosphamide 12314 tissue radiation exposure can be augmented when combined with alkylating chemotherapy drugs such as cyclophosphamide [[36]].Ovarian reserve assessmentOvarian reserve testing represents a cornerstone in counseling and
Select Disease Character Offset Disease Term Instance
Precocious puberty 24670 pulsatile rhythm of FSH/LH production can affect fertility and libido and can disrupt the menstrual cycle. Precocious puberty can occur after radiation doses of < 30 Gy and it may be caused by a disinhibition of cortical influence
hyperprolactinemia 44136 spectrum of radiation-induced pituitary deficiencies that could range from subclinical manifestations ( hyperprolactinemia with no clinical manifestation) to severe forms (precocious puberty, amenorrhea, galactorrhea, elevated
hypogonadism 31988 assisted reproductive technologies to conceive. Indeed, poor responder patients with hypogonadotropic hypogonadism co-stimulated with GH showed higher fertilization and pregnancy rates [[107]–[109]]. Little is known
ovarian dysfunction 12086 body irradiationHigh riskHigh riskHigh riskNevertheless, if only one side of the ovary is irradiated, ovarian dysfunction would occur in only half of all patients [[35]]. Furthermore, the risk of ovarian damage induced by
ovarian dysfunction 13275 inter−/intracycle variability and many studies agree that a normal FSH determination does not exclude ovarian dysfunction [[37]]. AMH measurement and antral follicle count (AFC) evaluation have been shown to have a higher
premature ovarian failure 28801 requiring pre- or postoperative pelvic or craniospinal radiation, a safe and effective strategy to prevent premature ovarian failure and to optimize future fertility is Ovarian Transposition (OT) [[97]–[99]]. OT is a surgical procedure
premature ovarian failure 38549 high-dose chemotherapy) and radiotherapy (54 Gy pelvic radiotherapy). After the treatment she developed a premature ovarian failure and at the age of 31 years-old she requested a re-transplantation because of childbearing desire. After
premature ovarian failure 43485 radiosentive and the subsequent depletion of follicle stores caused by radiations exposure may lead to premature ovarian failure , early menopause and infertility. Abdominal irradiation is also associated with alterations in uterine

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