Diabetic Retinopathy: Pathophysiology and Treatments.

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Term Occurence Count Dictionary
dexamethasone 2 endocrinologydiseasesdrugs
diabetes mellitus 2 endocrinologydiseases
diabetic retinopathy 2 endocrinologydiseases
hyperglycemia 2 endocrinologydiseases
Bevacizumab 1 endocrinologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
Bevacizumab 28233 PDR (CLARITY trial)a. Elevation in intraocular pressureb. Vitreous hemorrhagec. Inflammation [[47]] Bevacizumab (Avastin) [[47]]Off-label use Greater reduction in CRT and better median visual acuity over laser (DRCR.net
dexamethasone 16178 the clinical trials for DME treatment include the off-label triamcinolone acetonide, the FDA-approved dexamethasone (DEX) intravitreal implant and the fluocinolone acetonide (FA) intravitreal implant (Table 2).In the
dexamethasone 17166 releases corticosteroids into the vitreous in a sustained manner for up to six months. The utility of the dexamethasone delivery system ensures prolonged drug exposure and remarkably reduces the frequency of injections,
Select Disease Character Offset Disease Term Instance
diabetes mellitus 383 6/2018Publication date (collection): 6/2018AbstractDiabetic retinopathy (DR) is the most common complication of diabetes mellitus (DM). It has long been recognized as a microvascular disease. The diagnosis of DR relies on the detection
diabetes mellitus 1483 clinical trials are also reviewed.1. IntroductionDiabetic retinopathy (DR) is a major complication of diabetes mellitus (DM), which remains a leading cause of visual loss in working-age populations. The diagnosis of DR is
diabetic retinopathy 1737 vascular abnormalities in the retina. Clinically, DR is divided into two stages: non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). NPDR represents the early stage of DR, wherein
diabetic retinopathy 1783 Clinically, DR is divided into two stages: non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). NPDR represents the early stage of DR, wherein increased vascular permeability and capillary
hyperglycemia 4349 the pathogenesis of retinal microvascular damage. Multiple metabolic pathways have been implicated in hyperglycemia -induced vascular damage including the polyol pathway, advanced glycation end products (AGEs) accumulation,
hyperglycemia 4593 (PKC) pathway and the hexosamine pathway [[3]].The earliest responses of the retinal blood vessels to hyperglycemia are dilatation of blood vessels and blood flow changes. These changes are considered to be a metabolic

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