Low-carbohydrate diets for type 1 diabetes mellitus: A systematic review.

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Annotation Summary

Term Occurence Count Dictionary
hypoglycemia 2 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases
type 1 diabetes mellitus 4 endocrinologydiseases
Insulin 7 endocrinologydiseasesdrugs
diabetes mellitus 4 endocrinologydiseases
hyperinsulinemia 2 endocrinologydiseases

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Review

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Select Drug Character Offset Drug Term Instance
Insulin 686 Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, NSW, Australia [2] Insulin for Life Australia, Melbourne, Victoria, Australia [3]Discipline of Exercise and Sport Science, Faculty
Insulin 7072 population with the intervention. The medical subject headings used were ‘Diabetes Mellitus, Type 1’, ‘ Insulin Dependent Diabetes Mellitus’, ‘Insulin Deficiency’, ‘Diet, Carbohydrate-Restricted’, ‘Ketogenic
Insulin 7115 subject headings used were ‘Diabetes Mellitus, Type 1’, ‘Insulin Dependent Diabetes Mellitus’, ‘ Insulin Deficiency’, ‘Diet, Carbohydrate-Restricted’, ‘Ketogenic Diet’, ‘Low Carbohydrate Diet’,
Insulin 15753 (comparator).10.1371/journal.pone.0194987.t001Table 1Characteristics of included studies.Study DetailsPopulationaInterventionbComparatorb Insulin ProtocolcOutcomedAnderson 1991 [[20]]. United States. RCT (crossover).n 10. 47 (35–65) y. 18 (1–40)
Insulin 17113 diet). 4–5 months.-Controlled. Ambulatory CSII therapy. CSII installed 4–5 wk before study started. Insulin dose given 15 min before meals and assessed according to CHO amount ingested and pre-prandial glycemia.
Insulin 24795 1)730.0g12.0NA-Knight 2016I162 (143–204) (42 ± 7%)FLCD12 months (n 46)3.7 ± 15.70.2 ± 1.1P = 0.014-Total Daily Insulin (units/day)Bernstein 1980I15%TLCD5 years (n 1)80.025.0NA-Ireland 1992I~87 (22 ± 2%)TLCD2 weeks (n 8)41.1
Insulin 34653 in type 1 diabetes by decreasing the absolute amount of insulin required for tight glycaemic control. Insulin therapy is also a major confounder in all studies attempting to examine the effect of a lifestyle intervention
Select Disease Character Offset Disease Term Instance
diabetes mellitus 49 Title: PLoS ONELow-carbohydrate diets for type 1 diabetes mellitus : A systematic reviewAlternative Title: Low-carbohydrate diets for type 1 diabetesJessica L. Turton (Conceptualization)
diabetes mellitus 6088 review of the literature examining the effect of all low-carbohydrate diets for the management of type 1 diabetes mellitus . We set out to determine whether significant differences in type 1 diabetes management outcomes exist
diabetes mellitus 14103 study design was a review, letter or cross-sectional, seven studies were excluded because no type 1 diabetes mellitus sub-group were analysed, 27 studies were excluded because there was no low-carbohydrate diet intervention,
diabetes mellitus 42271 systematic review presents all available evidence for low-carbohydrate diets in the management of type 1 diabetes mellitus . The existing body of evidence is limited and more primary studies evaluating the short and long-term
hyperinsulinemia 34202 in type 1 diabetes increases susceptibility to severe hypoglycaemia and may lead to some measure of hyperinsulinemia [[29]]. Hyperinsulinemia is associated with; excessive weight gain [[30]], development of the metabolic
hyperinsulinemia 34535 Findings of the present review suggest that low-carbohydrate intakes may assist in reducing or preventing hyperinsulinemia in type 1 diabetes by decreasing the absolute amount of insulin required for tight glycaemic control.Insulin
hypoglycemia 21901 study that were measured and reported in included study of interest: Haemoglobin A1c (HbA1c), severe hypoglycemia (SH), total daily insulin (TDI), mean daily blood glucose (BG). Quality of life was not measured in
hypoglycemia 27119 study, sample size is 1 and/or raw data were not available for calculations.g: Frequency of severe hypoglycemia was reported as an average of 2 episodes daily. This was converted to 730 via simple calculation (2
metabolic syndrome 34313 hyperinsulinemia [[29]]. Hyperinsulinemia is associated with; excessive weight gain [[30]], development of the metabolic syndrome [[31]], inflammation and atherosclerosis [[32]], Alzheimer’s Disease [[33]] and cancer [[34]]. Findings
type 1 diabetes mellitus 42 Title: PLoS ONELow-carbohydrate diets for type 1 diabetes mellitus : A systematic reviewAlternative Title: Low-carbohydrate diets for type 1 diabetesJessica L. Turton (Conceptualization)
type 1 diabetes mellitus 6081 systematic review of the literature examining the effect of all low-carbohydrate diets for the management of type 1 diabetes mellitus . We set out to determine whether significant differences in type 1 diabetes management outcomes exist
type 1 diabetes mellitus 14096 because the study design was a review, letter or cross-sectional, seven studies were excluded because no type 1 diabetes mellitus sub-group were analysed, 27 studies were excluded because there was no low-carbohydrate diet intervention,
type 1 diabetes mellitus 42264 diseases.This systematic review presents all available evidence for low-carbohydrate diets in the management of type 1 diabetes mellitus . The existing body of evidence is limited and more primary studies evaluating the short and long-term

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