Curcumin, Cardiometabolic Health and Dementia

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
type 2 diabetes mellitus 1 endocrinologydiseases
Insulin 1 endocrinologydiseasesdrugs
atorvastatin 2 endocrinologydiseasesdrugs
cortisol 2 endocrinologydiseasesdrugs
diabetes mellitus 2 endocrinologydiseases
metabolic syndrome 10 endocrinologydiseases
obesity 4 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Insulin 1684 impaired insulin signalling, leading to hyperglycaemia and micro and macrovascular diseases [[1],[2]]. Insulin resistance is a major contributor to the pathogenesis of T2DM with secondary pancreatic failure [[2],[3]].
atorvastatin 42947 on endothelial function through anti-inflammatory and antioxidant actions are comparable to those of atorvastatin (10 mg/day). However, in comparison with the baseline, NCB-02 did not significantly alter fasting glucose,
atorvastatin 43104 baseline, NCB-02 did not significantly alter fasting glucose, HbA1c, TC, LDL-C HDL-C and TG, while atorvastatin significantly lowered TC, LDL-C and TG [[108]].In a double-blind, parallel, randomised study of healthy
cortisol 43860 adiponectin, leptin, insulin, HOMA-IR, oxidised LDL-C, total antioxidant status, GPx, IL-6, TNF-α, cortisol , epinephrine, norepinephrine and endothelin-1 (ET-1) compared with baseline or placebo [[144]].Curcumin
cortisol 67679 placeboadiponectin, leptin, insulin, HOMA-IR, oxidised LDL-C, total antioxidant status, GPx, IL-6, TNF-α, cortisol , ET-1 FMD resistance artery endothelial function (FBFACh)Santos-Parker et al. 2017 [[144]]45–180 mg/day
Select Disease Character Offset Disease Term Instance
diabetes mellitus 1817 contributor to the pathogenesis of T2DM with secondary pancreatic failure [[2],[3]]. The prevalence of diabetes mellitus will increase worldwide from 451 million people aged over 18 in 2017 to 693 million people in 2045 [[4]].
diabetes mellitus 71227 TC—total cholesterol; TG—triglyceride; TGF-β—transforming growth factor beta; T2DM—type 2 diabetes mellitus ; TNF-α—tumor necrosis factor-alpha; VLDL—very low-density lipoprotein; VEGF—vascular endothelial
metabolic syndrome 21349 adiponectin levels were observed with curcumin supplementation (1 g/day) for 6 weeks in subjects with metabolic syndrome compared with a curcumin-phospholipid complex group or a placebo group, whereas no differences in BMI,
metabolic syndrome 28239 [[134],[143],[146],[163],[164]].In a randomised double-blind, placebo-controlled parallel study of 117 subjects with metabolic syndrome (aged 25–75 years), supplementation of 1000 mg/day of curcuminoids and piperine (bioperine® Sami
metabolic syndrome 29436 [[57]].In a randomised, double-blind, placebo-controlled trial, 33 subjects aged 40–60 years with metabolic syndrome (mean BMI: 30.06 ± 4.12 kg/m2) were supplemented with 630 mg of curcumin extract (95% curcuminoids,
metabolic syndrome 35608 and LDL-C compared with the placebo [[45]].In a randomised parallel trial, overweight subjects with metabolic syndrome (mean BMI 25–29.9 kg/m2; mean age 39.1 ± 16.8 years; n = 44) who adhered to a diet plus lifestyle
metabolic syndrome 39749 affect the gut microbiota [[204],[205],[206],[207]]. Gut microbial dysbiosis is associated with obesity, metabolic syndrome , diabetes, CVD and neurodegenerative diseases [[208],[209],[210],[211],[212]].Very limited studies showed
metabolic syndrome 61631 2 day of phosphatidylserine + lifestyle interventionrandomised parallel44 overweight subjects with metabolic syndrome (mean BMI 25–29.9 kg/m2; mean age 39.1 ± 16.8 years)4 weeks↓ body weight, ↓ body fat, ↓ waistline,
metabolic syndrome 64362 IL-6, IL-8, IL-10, IFN γ, EGF, MCP-1Ganjali et al. 2014 [[111]]1 g/day of curcumin117 subjects with metabolic syndrome 8 weeks↓ TNF-α, ↓ IL-6, ↓ TGF-β, ↓MCP-1 compared with placeboPanahi et al. 2016 [[112]]500
metabolic syndrome 65869 curcumin (n = 40), or placebo (n = 40)Randomised, double-blind, placebo-controlled120 subjects with metabolic syndrome aged 18–65 years6 weeks↑ adiponectin in the unformulated curcumin group compared with the curcumin-phospholipid
metabolic syndrome 67219 curcumin extractrandomised, double-blind, placebo-controlled33 subjects aged over 40–60 years with metabolic syndrome (mean BMI: 30.06 ± 4.12 kg/m2)12 weeks↓ LDL-Ccompared with the placeboweight, BMI, fasting glucose,
metabolic syndrome 69236 (bioperine®) (100: 1 ratio combination)randomised double-blind, placebo-controlled parallel117 subjects with metabolic syndrome (aged 25–75 years)8 weeks↓ LDL-C, ↓non-HDL-C,↓ TC, ↓ TG, ↓ Lp(a),↑ HDL-Ccompared with
obesity 21964 leptin levels compared with the placebo. Pulse wave velocity (PWV), HOMA-IR, TG, uric acid, abdominal obesity (visceral fat and total body fat) were significantly reduced with curcumin treatment compare with the
obesity 26814 adipocytes, by decreasing ER stress (elevated ER stress in adipocytes and hepatocytes is related to obesity ) and perigonadal fat expression of Sirtuin 1 (SIRT1), heat shock proteins (HSP70), HSP90 and Foxo1 and
obesity 37181 enzyme in the synthesis of unsaturated fatty acids [[190]]. Upregulation of SCD-1 may be associated with obesity , insulin resistance and atherosclerosis [[191]]. Curcumin (80 mg/kg) treatment for 12 weeks in HFD-induced
obesity 39740 can affect the gut microbiota [[204],[205],[206],[207]]. Gut microbial dysbiosis is associated with obesity , metabolic syndrome, diabetes, CVD and neurodegenerative diseases [[208],[209],[210],[211],[212]].Very
type 2 diabetes mellitus 71220 substances; TC—total cholesterol; TG—triglyceride; TGF-β—transforming growth factor beta; T2DM— type 2 diabetes mellitus ; TNF-α—tumor necrosis factor-alpha; VLDL—very low-density lipoprotein; VEGF—vascular endothelial

You must be authorized to submit a review.