The role and function of HDL in patients with diabetes mellitus and the related cardiovascular risk.

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Term Occurence Count Dictionary
niacin 1 endocrinologydiseasesdrugs
obesity 1 endocrinologydiseases
type 2 diabetes mellitus 1 endocrinologydiseases
Insulin 1 endocrinologydiseasesdrugs
diabetes mellitus 11 endocrinologydiseases
hyperinsulinemia 2 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 17686 of T2 diabetes mellitus is associated with insulin resistance, hyperglycaemia and hyperinsulinemia. Insulin resistance was shown to increase free fatty acids availability, while hyperinsulinemia and hyperglycaemia
niacin 27918 effect on endothelial nitric oxide synthesis in patients with type 2 diabetes. However, extended-release niacin therapy improved the capacity of HDL to stimulate endothelial nitric oxide, to decrease superoxide production,
Select Disease Character Offset Disease Term Instance
diabetes mellitus 81 Title: Lipids in Health and DiseaseThe role and function of HDL in patients with diabetes mellitus and the related cardiovascular riskMarek FemlakAnna Gluba-BrzózkaAleksandra Ciałkowska-RyszJacek RyszPublication
diabetes mellitus 478 problem which prevalence is constantly raising, particularly in low- and middle-income countries. Both diabetes mellitus types (DMT1 and DMT2) are associated with high risk of developing chronic complications, such as retinopathy,
diabetes mellitus 761 atherosclerosis.MethodsThis is a review of available articles concerning HDL subfractions profile in diabetes mellitus and the related cardiovascular risk. In this review, HDL dysfunction in diabetes, the impact of HDL
diabetes mellitus 1696 lipoprotein-associated phospholipase 11 (Lp-PLA2) are altered. HDL properties are compromised in patients with diabetes mellitus (DM), due to oxidative modification and glycation of the HDL protein as well as the transformation of
diabetes mellitus 2822 and other diseases [[1]]. In 2014, 422 million people in the world suffered from diabetes [[1]]. Both diabetes mellitus types (DMT1 and DMT2) are associated with high risk of developing chronic complications, such as retinopathy,
diabetes mellitus 11972 observation that intravenous reconstituted HDL (rHDL) reduced plasma glucose in patients with type 2 diabetes mellitus by increasing plasma insulin and stimulating AMP-activated protein kinase in skeletal muscle further
diabetes mellitus 17370 [66], [67]]. According to studies, concentrations of HDL cholesterol are diminished in patients with diabetes mellitus type 2 [[68], [69]]. Moreover, the predominance of small dense HDL particles which undergo rapid catabolism
diabetes mellitus 17592 catabolism has been also reported [[8], [68], [69]].Hypertriglyceridemia which appears in the course of T2 diabetes mellitus is associated with insulin resistance, hyperglycaemia and hyperinsulinemia. Insulin resistance was shown
diabetes mellitus 23961 noteworthy that many of the aforementioned lipids-related alterations are present before the onset of diabetes mellitus as a result of insulin-resistant metabolic syndrome [[19]].HDL subfractions and cardiovascular risk
diabetes mellitus 24584 with a MI history. Moreover, diffuse, severe atherosclerotic lesions were observed in patients with diabetes mellitus . Potential mechanisms responsible for these worse outcomes in patients with T2D have not been fully
diabetes mellitus 29247 antioxidative and anti-inflammatory capacities. However, these properties are compromised in patients with diabetes mellitus (DM), due to oxidative modification and glycation of the HDL protein as well as the transformation of
hyperinsulinemia 17668 appears in the course of T2 diabetes mellitus is associated with insulin resistance, hyperglycaemia and hyperinsulinemia . Insulin resistance was shown to increase free fatty acids availability, while hyperinsulinemia and
hyperinsulinemia 17764 and hyperinsulinemia. Insulin resistance was shown to increase free fatty acids availability, while hyperinsulinemia and hyperglycaemia promote triglyceride synthesis via the activation of carbohydrate-responsive element-binding
metabolic syndrome 24012 lipids-related alterations are present before the onset of diabetes mellitus as a result of insulin-resistant metabolic syndrome [[19]].HDL subfractions and cardiovascular risk in DM patientsNumerous large epidemiologic studies and
obesity 19218 between HDL-ApoA-I catabolism rate and plasma levels of adiponectin, which was independent of abdominal obesity , insulin sensitivity, age, and sex and plasma lipids. Their finding suggests a direct impact of adiponectin
type 2 diabetes mellitus 11965 [[46]]. The observation that intravenous reconstituted HDL (rHDL) reduced plasma glucose in patients with type 2 diabetes mellitus by increasing plasma insulin and stimulating AMP-activated protein kinase in skeletal muscle further

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