Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals.

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
cholecalciferol 1 endocrinologydiseasesdrugs
ergocalciferol 1 endocrinologydiseasesdrugs
hyperglycemia 2 endocrinologydiseases
obesity 8 endocrinologydiseases
polycystic ovary syndrome 1 endocrinologydiseases
Insulin 2 endocrinologydiseasesdrugs
cholic acid 1 endocrinologydiseasesdrugs
diabetes mellitus 4 endocrinologydiseases
metabolic syndrome 4 endocrinologydiseases
type 2 diabetes mellitus 4 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Insulin 6650 very low density lipoprotein particles in a liver with increased fat content is also important [[20]]. Insulin resistance plays a pivotal role in the “first-hit” and in liver triglyceride accumulation. Increasing
Insulin 8547 important role in the development of insulin resistance, visceral obesity, and gut microbiome changes. Insulin resistance promotes steatosis with the mechanisms above discussed; adipose tissue is involved beyond
cholecalciferol 48664 in the skin after ultraviolet irradiation. Vitamin D2 and vitamin D3, also called ergocalciferol and cholecalciferol , are the two main forms of vitamin D. Vitamin D plays a prominent role in calcium and phosphorus metabolism
cholic acid 65177 ALT: alanine aminotransferase; AST: aspartate aminotransferase; n.a.: not assessed; UDAC: ursodeoxy cholic acid ; IU: international unit; US: ultrasonography; NAFLD non-alcoholic fatty liver disease.nutrients-09-01065-t006_Table
ergocalciferol 48645 is also produced in the skin after ultraviolet irradiation. Vitamin D2 and vitamin D3, also called ergocalciferol and cholecalciferol, are the two main forms of vitamin D. Vitamin D plays a prominent role in calcium
Select Disease Character Offset Disease Term Instance
diabetes mellitus 3080 cardiometabolic abnormalities strictly related to the increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Interestingly, NAFLD itself can be considered as an independent cardiometabolic risk factor
diabetes mellitus 56213 MUFA: monounsaturated fatty acids; n-6 PUFA: n-6 polyunsaturated fatty acids; vs.: versus; T2DM: type 2 diabetes mellitus ; M: male; F: female; CHO: carbohydrates; GI: glycemic index; SFA: saturated fatty acids; 1H-MRS: proton
diabetes mellitus 60691 significant decrease; ↑ significant increase. BMI: body mass index; M: male; F: female; T2DM: type 2 diabetes mellitus ; ALT: alanine aminotransferase; AST: aspartate aminotransferase; n.a.: not assessed; ADA: American Diabetes
diabetes mellitus 66321 kg/m2= no changes; ↓ significant decrease; BMI: body mass index; M: male; F: female; T2DM: type 2 diabetes mellitus ; ALT: alanine aminotransferase; AST: aspartate aminotransferase; n.a.: not assessed; US: ultrasonography;
hyperglycemia 4422 vascular functions, as well as of dyslipidemia, hypertension, abdominal obesity, insulin resistance and hyperglycemia . All these abnormalities identify the metabolic syndrome; consequently, the close association between
hyperglycemia 15386 with abdominal obesity and other metabolic abnormalities as well as dyslipidemia, hypertension, and hyperglycemia .We have comprehensively evaluated the evidence from randomized controlled trials performed in humans
metabolic syndrome 4474 hypertension, abdominal obesity, insulin resistance and hyperglycemia. All these abnormalities identify the metabolic syndrome ; consequently, the close association between NAFLD and metabolic syndrome is unsurprising [[6],[7]].
metabolic syndrome 4548 abnormalities identify the metabolic syndrome; consequently, the close association between NAFLD and metabolic syndrome is unsurprising [[6],[7]]. In line with these observations, the prevalence of NAFLD is approximately
metabolic syndrome 5009 nearly 70–80% of obese children may have NAFLD [[11]]. Given the increasing prevalence of obesity and metabolic syndrome , NAFLD will become one of the most important public health challenges in the next decades for its related
metabolic syndrome 49147 literature has shown that serum levels of vitamin D are inversely associated with insulin resistance, metabolic syndrome , CVD, diabetes and NAFLD [[169],[170],[171]]. A meta-analysis showed that subjects with NAFLD were 26%
obesity 2706 habits typical of the last forty years, have been associated with a dramatic increase in overweight/ obesity and insulin resistance and, more recently, also with non-alcoholic fatty liver disease (NAFLD) [[1]].
obesity 4390 alterations in metabolic and vascular functions, as well as of dyslipidemia, hypertension, abdominal obesity , insulin resistance and hyperglycemia. All these abnormalities identify the metabolic syndrome; consequently,
obesity 4997 indicate that nearly 70–80% of obese children may have NAFLD [[11]]. Given the increasing prevalence of obesity and metabolic syndrome, NAFLD will become one of the most important public health challenges in the
obesity 8510 and genetic predisposition play an important role in the development of insulin resistance, visceral obesity , and gut microbiome changes. Insulin resistance promotes steatosis with the mechanisms above discussed;
obesity 15301 components on NAFLD in people at high cardiometabolic risk, in particular individuals with abdominal obesity and other metabolic abnormalities as well as dyslipidemia, hypertension, and hyperglycemia.We have comprehensively
obesity 21377 (reduction of triglycerides, VLDL, LDL and oxidized-LDL, and an increase in HDL), insulin resistance and obesity -related inflammation [[62],[63]].As for the effect of n-6 PUFA on NAFLD, only one study met our inclusion
obesity 35943 correlation between high polyphenol consumption and incidence of many chronic metabolic diseases, including obesity , insulin resistance, and CVD [[119]]. A randomized controlled trial in individuals at high cardiometabolic
obesity 46671 literature has shown an inverse correlation between vitamin C deficiency and some chronic diseases, as obesity , hypertension, and CVD [[156]]. The results of epidemiological studies are conflicting about a possible
polycystic ovary syndrome 25511 colleagues [[72]] compared the effects of the daily consumption of n-3 PUFA or MUFA in a group of women with polycystic ovary syndrome , a condition associated with NAFLD. According to an eight-week crossover randomized and controlled trial,
type 2 diabetes mellitus 3073 cardiometabolic abnormalities strictly related to the increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Interestingly, NAFLD itself can be considered as an independent cardiometabolic risk factor
type 2 diabetes mellitus 56206 index; MUFA: monounsaturated fatty acids; n-6 PUFA: n-6 polyunsaturated fatty acids; vs.: versus; T2DM: type 2 diabetes mellitus ; M: male; F: female; CHO: carbohydrates; GI: glycemic index; SFA: saturated fatty acids; 1H-MRS: proton
type 2 diabetes mellitus 60684 ↓ significant decrease; ↑ significant increase. BMI: body mass index; M: male; F: female; T2DM: type 2 diabetes mellitus ; ALT: alanine aminotransferase; AST: aspartate aminotransferase; n.a.: not assessed; ADA: American Diabetes
type 2 diabetes mellitus 66314 ↓30.3 kg/m2= no changes; ↓ significant decrease; BMI: body mass index; M: male; F: female; T2DM: type 2 diabetes mellitus ; ALT: alanine aminotransferase; AST: aspartate aminotransferase; n.a.: not assessed; US: ultrasonography;

You must be authorized to submit a review.