Roles of miRNAs and long noncoding RNAs in the progression of diabetic retinopathy.

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diabetic retinopathy 1 endocrinologydiseases
hyperglycemia 5 endocrinologydiseases

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diabetic retinopathy 87 Title: Bioscience ReportsRoles of miRNAs and long noncoding RNAs in the progression of diabetic retinopathy Qiaoyun GongGuanfang SuPublication date (epreprint): 10/2017Publication date (epub): 11/2017Publication
hyperglycemia 14014 we identified several miRNAs, both in HRECs and ARPE-19 cells, whose levels increase with time under hyperglycemia ; the levels of these miRNAs also increase in the retinas of STZ-induced DM rats for 4, 6, and 8 weeks
hyperglycemia 14338 miR-199a-5p showed a gradually decreased expression in HRECs and RPE cells; this paralleled an increase in hyperglycemia -treatment time. miR-145-5p and miR-146a-5p exhibited the opposite changes in expression (down-regulation
hyperglycemia 29734 miR-15b and miR-16 play a role in the inhibition of insulin resistance, resulting in HREC protection from hyperglycemia -induced apoptosis [[67]]. In addition to investigating the regulatory effects of miR-15a and miR-16
hyperglycemia 33195 levels of a number of growth and vasoactive factors, especially VEGF, are increased in response to hyperglycemia . Dysfunction of ECs is the primary cellular pathology in complications of chronic diabetes. ECs undergo
hyperglycemia 57312 [[98]] put forward a model that includes lncRNA-MIAT, miR-150-5p, and VEGF mRNA. In diabetic rats, hyperglycemia significantly up-regulates MIAT levels; miR-150-5p knockdown can further increase MIAT levels. MIAT

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