Dietary Anthocyanins against Obesity and Inflammation.

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
rosiglitazone 1 endocrinologydiseasesdrugs
Insulin 1 endocrinologydiseasesdrugs
dexamethasone 2 endocrinologydiseasesdrugs
diabetes mellitus 1 endocrinologydiseases
glucose intolerance 1 endocrinologydiseases
hyperglycemia 2 endocrinologydiseases
obesity 44 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Insulin 8596 preadipocyte and adipose-derived stem cells were developed, which also require adipogenic stimuli ( Insulin , dexamethasone, IBMX, biotin, rosiglitazone) for differentiation to mature adipocytes by transcriptional
dexamethasone 7925 well-established methodology for mature adipocytes. When adipogenic stimuli such as insulin (1 to 10 μg/mL), dexamethasone , (1 μM) and 3-isobutyl-1-methylxanthine (IBMX) (0.5 mM) are added to medium containing 10% fetal bovine
dexamethasone 8605 preadipocyte and adipose-derived stem cells were developed, which also require adipogenic stimuli (Insulin, dexamethasone , IBMX, biotin, rosiglitazone) for differentiation to mature adipocytes by transcriptional cascades within
rosiglitazone 8634 cells were developed, which also require adipogenic stimuli (Insulin, dexamethasone, IBMX, biotin, rosiglitazone ) for differentiation to mature adipocytes by transcriptional cascades within 12–14 days [[30]]. Recent
Select Disease Character Offset Disease Term Instance
diabetes mellitus 2153 associated chronic diseases such as cardiovascular diseases, pulmonary diseases, cancer, and type II diabetes mellitus [[1],[2]]. Continuous effort has been made to understand the pathogenesis between obesity and chronic
glucose intolerance 10154 developed by high energy diets have shown the characteristic symptoms of metabolic disorders such as glucose intolerance and upregulation of cholesterol and triglycerides in the plasma of animals [[32]]. Diet-induced obese
hyperglycemia 1970 chronic diseases.1. IntroductionObesity is accompanied by metabolic disturbances such as dyslipidemia, hyperglycemia and hypertension. The burden of obesity is largely derived from its associated chronic diseases such
hyperglycemia 9329 autosomal recessive for a mutation in leptin receptors, and consequently exhibit metabolic symptoms such as hyperglycemia and insulin resistance [[35]]. Despite the metabolic disorder phenotype displayed in these monogenic
obesity 720 (collection): 10/2017AbstractChronic low-grade inflammation plays a pivotal role in the pathogenesis of obesity , due to its associated chronic diseases such as type II diabetes, cardiovascular diseases, pulmonary
obesity 930 diseases and cancer. Thus, targeting inflammation is an attractive strategy to counter the burden of obesity -induced health problems. Recently, food-derived bioactive compounds have been spotlighted as a regulator
obesity 1223 that induce severe side effects. Here we describe the beneficial effects of dietary anthocyanins on obesity -induced metabolic disorders and inflammation. Red cabbage microgreen, blueberry, blackcurrant, mulberry,
obesity 1701 markers in cells, animals, and humans. This review discusses the interplay between inflammation and obesity , and their subsequent regulation via the use of dietary anthocyanins, suggesting an alternative dietary
obesity 1836 regulation via the use of dietary anthocyanins, suggesting an alternative dietary strategy to ameliorate obesity and obesity associated chronic diseases.1. IntroductionObesity is accompanied by metabolic disturbances
obesity 1848 the use of dietary anthocyanins, suggesting an alternative dietary strategy to ameliorate obesity and obesity associated chronic diseases.1. IntroductionObesity is accompanied by metabolic disturbances such as
obesity 2016 accompanied by metabolic disturbances such as dyslipidemia, hyperglycemia and hypertension. The burden of obesity is largely derived from its associated chronic diseases such as cardiovascular diseases, pulmonary diseases,
obesity 2253 diabetes mellitus [[1],[2]]. Continuous effort has been made to understand the pathogenesis between obesity and chronic diseases. Interestingly, chronic low-grade inflammation has been linked to the progression
obesity 2367 chronic diseases. Interestingly, chronic low-grade inflammation has been linked to the progression of obesity and its related diseases [[3],[4]].Inflammation is a defense system that responds to harmful stimuli
obesity 2870 cells (APC) and B- and T lymphocytes perform adaptive immunity which may increase the prevalence of obesity -associated chronic diseases [[6]]. Thus, preventing this prolonged pro-inflammatory condition can be
obesity 3004 diseases [[6]]. Thus, preventing this prolonged pro-inflammatory condition can be a valid strategy against obesity -associated metabolic disorders [[7],[8]].Although there are a number of drugs that are approved for
obesity 3433 bioactive components such as phenolic compounds is positively associated with reducing the risk of obesity and its associated chronic diseases with low toxicity [[10],[11]]. Thus, creating new dietary treatments
obesity 3649 based on various bioactive components in food has been emerging as a new possible intervention against obesity [[12],[13]].Anthocyanins are an important subfamily of flavonoids, which are abundant in flowers, fruits,
obesity 4745 beneficial for improving human health [[18]].Collectively, over the last two decades, the link between obesity and inflammation has been highlighted as a new axis to be targeted for intervention. Dietary bioactive
obesity 4909 be targeted for intervention. Dietary bioactive components that have beneficial effects against both obesity and inflammation can potentially be a modulator of this axis. Here we discuss the impact of dietary
obesity 5045 potentially be a modulator of this axis. Here we discuss the impact of dietary anthocyanins on alleviating obesity and inflammation.2. Metainflammation and Its MechanismObesity is accompanied by a chronic low-grade
obesity 6585 immune system and metabolism, developing novel immunotherapeutic strategies to simultaneously attenuate obesity -related metabolic disorders seems promising. Indeed, targeting IL-1β, IL-1β receptor, TNF-α, TLRs,
obesity 6814 were effective in reducing blood glucose levels, insulin resistance and other metabolic markers in obesity [[7],[8]]. Flavonoids have also been assessed to regulate inflammation and obesity by lowering IL-1α,
obesity 6897 metabolic markers in obesity [[7],[8]]. Flavonoids have also been assessed to regulate inflammation and obesity by lowering IL-1α, and IFN-γ compared to control mice [[24]]. These efforts have diversely been attempted
obesity 7146 models [[25]].3. Establishment of an Obesity Model Cells and animals are essential surrogates for human obesity due to the limitations of promising human studies. In this section, we introduce frequently used cell
obesity 7283 promising human studies. In this section, we introduce frequently used cell and animal models of human obesity (Table 1).Fat accumulation in adipose tissue is critical for obesity. Adipose tissue is composed of
obesity 7352 cell and animal models of human obesity (Table 1).Fat accumulation in adipose tissue is critical for obesity . Adipose tissue is composed of adipocytes, macrophages, mesenchymal stem cells, blood cells, fibroblasts,
obesity 8400 mature adipocyte within 14 days [[28]]. Mouse cell models can be easily applied to study adipogenesis in obesity , but there are some metabolic differences with human adipocytes [[29]]. Therefore, human preadipocyte
obesity 8764 differentiation to mature adipocytes by transcriptional cascades within 12–14 days [[30]]. Recent studies of obesity in vitro have utilized not only the above described cell models but also utilized co-culture and three
obesity 9510 phenotype displayed in these monogenic models, these models are limited in their representation of human obesity since they are induced via a mutation of a gene [[36]]. Diet-induced obesity models have been alternatively
obesity 9587 representation of human obesity since they are induced via a mutation of a gene [[36]]. Diet-induced obesity models have been alternatively suggested to overcome this limitation. These animals are instead fed
obesity 10539 These valid models may lead us to predict the mechanism and efficacy of target molecules for human obesity .4. Biological Functions of AnthocyaninsAnthocyanins are well-known antioxidants that eliminate reactive
obesity 13998 Inflammation and Obesity in Various ModelsTable 2 presents the beneficial effects of dietary anthocyanins on obesity -related metabolic markers and inflammatory markers in cells and animals. Because there are many studies
obesity 14157 in cells and animals. Because there are many studies with respect to the effects of anthocyanins on obesity and inflammation, we look at studies of dietary anthocyanins which are clearly defined for their bioactive
obesity 16573 have also been conducted to evaluate biological functions of dietary anthocyanins on inflammation and obesity , as shown in Table 3. Due to the lack of clinical studies, studies without characterization of anthocyanins
obesity 17233 effective in reducing metabolic markers and inflammatory markers in human subjects.7. SummaryPreviously, obesity was regarded as just a matter of excessive energy storage triggered by energy imbalance, however many
obesity 17449 studies have indicated that chronic low-grade inflammation in adipose tissue can be an important issue in obesity . In particular, this metainflammation could enable pathogenesis of chronic diseases associated with
obesity 17557 In particular, this metainflammation could enable pathogenesis of chronic diseases associated with obesity . Anthocyanins have great biological activities and low toxicity in vivo, therefore many scientists are
obesity 17803 of anthocyanins, as well as their application in preventing and treating chronic diseases, including obesity . Here, we describe the positive effects of dietary anthocyanins limited to their well-defined components
obesity 17985 their well-defined components against metabolic and inflammatory markers in cell, animal and human obesity models. In addition, anthocyanin mixtures found in food such as red cabbage microgreen, blueberry, blackcurrant,
obesity 18357 single anthocyanins.8. ConclusionsWe reviewed the effects of anthocyanins-rich food on attenuating obesity and inflammation in cells, animals, and humans. Taken together, dietary anthocyanins may be a potential
obesity 18482 in cells, animals, and humans. Taken together, dietary anthocyanins may be a potential regulator of obesity -derived inflammation and its associated chronic diseases, as presented in Figure 2.Figure 1Structure
obesity 18669 Figure 2.Figure 1Structure of the most common anthocyanins.Figure 2Beneficial effects of anthocyanins on obesity and inflammation. When receptors recognize the status of over-nutrition, they activate various transcription
obesity 19168 effects on these events, leading to health benefits.nutrients-09-01089-t001_Table 1Table 1Frequently used obesity model in vitro and in vivo.AdvantageDisadvantageIn vitromousemesenchymal stem cellsembryonic stem cellsprimary
obesity 19483 vs. mousehumanpreadipocytesadipose-derived stem cellseasy to study mechanism,representation of human obesity complement of mouse cell lines‘ disadvantagesIn vivomonogenicob/ob miceZucker fatty ratsapparent symptoms
obesity 19704 metabolic disordersmonogenic mutation is rare in humanspolygenicHigh energy diets-fed miceDiet-induced obesity resemble complexities of human obesitycomplement of monogenic models‘ disadvantagesnutrients-09-01089-t002_Table
obesity 19742 rare in humanspolygenicHigh energy diets-fed miceDiet-induced obesityresemble complexities of human obesity complement of monogenic models‘ disadvantagesnutrients-09-01089-t002_Table 2Table 2Effects of dietary
obesity 19869 monogenic models‘ disadvantagesnutrients-09-01089-t002_Table 2Table 2Effects of dietary anthocyanins on obesity and inflammation (cell and animal study).Food SourcesIdentified Bioactive Dose of AnthocyaninsMediatorsInducerMetabolic
obesity 24184 weight. CRP: C-reactive protein.nutrients-09-01089-t003_Table 3Table 3Effects of dietary anthocyanins on obesity and inflammation (clinical study).Food SourcesBioactives Dose of AnthocyaninsSubject DurationMetabolic

You must be authorized to submit a review.