Rhabdomyolysis, lactic acidosis, and multiple organ failure during telbivudine treatment for hepatitis B: a case report and review of the literature.

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methylprednisolone 6 endocrinologydiseasesdrugs
prednisone 1 endocrinologydiseasesdrugs
dexamethasone 1 endocrinologydiseasesdrugs
diabetes mellitus 1 endocrinologydiseases
lactic acidosis 28 endocrinologydiseases

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dexamethasone 9211 replacement therapy (for 8 days), D 1 Day 1, GC glucocorticoid therapy (including methylprednisolone, dexamethasone , and prednisone, for 44 days), HBO hyperbaric oxygen therapy (for 40 days), LMS muscle strength of
methylprednisolone 1323 lactate (>20.0 mmol/L). His symptoms improved after continuous renal replacement therapy and short-term methylprednisolone treatment. Hyperbaric oxygen therapy, physical therapy, and rehabilitation for more than 2 months led
methylprednisolone 7199 (4.0–10.0 × 109/L)Continuous renal replacement therapy (CRRT) was maintained for 10 days, and methylprednisolone was initiated at 80 mg twice daily. These treatments led to improvements in his chest pain, dyspnea,
methylprednisolone 9191 continuous renal replacement therapy (for 8 days), D 1 Day 1, GC glucocorticoid therapy (including methylprednisolone , dexamethasone, and prednisone, for 44 days), HBO hyperbaric oxygen therapy (for 40 days), LMS muscle
methylprednisolone 15895 as early as possible. Despite delays in diagnosis and treatment, our patient improved after CRRT and methylprednisolone therapy, which played key roles in the telbivudine-induced rhabdomyolysis, lactic acidosis, and MOF.The
methylprednisolone 16268 patient’s elevated lactate level in his blood and rhabdomyolysis improved significantly after CRRT and methylprednisolone therapy. But in another study, a patient with telbivudine-induced rhabdomyolysis only received hemofiltration
methylprednisolone 16827 return the blood lactate level to normal, and the current study also indicated that CRRT combined with methylprednisolone therapy help to reduce the blood lactate level to normal.However, we found that low-dose glucocorticoid
prednisone 9230 (for 8 days), D 1 Day 1, GC glucocorticoid therapy (including methylprednisolone, dexamethasone, and prednisone , for 44 days), HBO hyperbaric oxygen therapy (for 40 days), LMS muscle strength of lower extremities
Select Disease Character Offset Disease Term Instance
diabetes mellitus 13832 another previous study, our patient also had no heavy exercise or heavy drinking, and had no history of diabetes mellitus [[18]]. Thus the risk factors for telbivudine-induced lactic acidosis or MOF are still ambiguous and
lactic acidosis 54 Title: Journal of Medical Case ReportsRhabdomyolysis, lactic acidosis , and multiple organ failure during telbivudine treatment for hepatitis B: a case report and review of
lactic acidosis 493 /2017AbstractBackgroundTelbivudine can cause severe side effects, including myositis, neuritis, rhabdomyolysis, and lactic acidosis . However, reported cases of telbivudine leading to multiple organ failure are rare. Here, we report
lactic acidosis 660 multiple organ failure are rare. Here, we report a case of telbivudine-induced severe polymyositis, lactic acidosis , and multiple organ failure.Case presentationA 30-year-old Chinese man with hepatitis B virus infection
lactic acidosis 1648 replacement and steroid therapies play key roles in stabilizing telbivudine-induced severe rhabdomyolysis, lactic acidosis , and multiple organ failure. Hyperbaric oxygen, physical therapy, and rehabilitation may aid in functional
lactic acidosis 1805 oxygen, physical therapy, and rehabilitation may aid in functional recovery after the acute phase of lactic acidosis and organ failure.BackgroundOne of the most common infectious diseases in the world, chronic hepatitis
lactic acidosis 2801 patients with pre-existing muscle damage [[4]]. Telbivudine can also cause fatal rhabdomyolysis and lactic acidosis [[5], [6]].Telbivudine-associated elevation of CK levels, myopathy, hyperlactatemia, and rhabdomyolysis
lactic acidosis 3137 who was treated for 11 months with telbivudine for HBV and subsequently developed rhabdomyolysis, lactic acidosis , and MOF.Case presentationA 30-year-old Chinese man who had been HBeAg-positive for at least 10 years
lactic acidosis 4827 U/L; Table 1). He was put on continuous mechanical ventilation. Arterial blood gas analysis revealed lactic acidosis , with a partial pressure of oxygen (PO2) of 63 mmHg, partial pressure of carbon dioxide in arterial
lactic acidosis 11300 date, reports of telbivudine-induced severe side effects, such as rhabdomyolysis, hyperlactatemia, lactic acidosis , or MOF, have been very rare. Jin et al. described a 36-year-old man who developed severe refractory
lactic acidosis 11417 or MOF, have been very rare. Jin et al. described a 36-year-old man who developed severe refractory lactic acidosis during telbivudine monotherapy. He fully recovered after 16 weeks of hemodialysis and glucocorticosteroid
lactic acidosis 12660 (mmol/L)PrognosisReference127MyopathyCHB33243–Resolved[[4]]267MyopathyCHB204775–Resolved[[14]]325MyopathyCHB61614–Resolved[[15]]428MyopathyCHB9788–Resolved[[16]]525MyopathyCHB132992–Resolved[[16]]668MyopathyCHB2237–Resolved[[17]]735Rhabdomyolysis, lactic acidosis CHB113683> 12.0Resolved[[6]]826lactic acidosisCHB12415111.3Resolved[[18]]930Rhabdomyolysis, lactic
lactic acidosis 12708 (mmol/L)PrognosisReference127MyopathyCHB33243–Resolved[[4]]267MyopathyCHB204775–Resolved[[14]]325MyopathyCHB61614–Resolved[[15]]428MyopathyCHB9788–Resolved[[16]]525MyopathyCHB132992–Resolved[[16]]668MyopathyCHB2237–Resolved[[17]]735Rhabdomyolysis, lactic acidosisCHB113683> 12.0Resolved[[6]]826 lactic acidosis CHB12415111.3Resolved[[18]]930Rhabdomyolysis, lactic acidosis, organ failureCHB118050> 20.0ResolvedThis
lactic acidosis 12769 acidosisCHB113683> 12.0Resolved[[6]]826lactic acidosisCHB12415111.3Resolved[[18]]930Rhabdomyolysis, lactic acidosis , organ failureCHB118050> 20.0ResolvedThis paper1048Rhabdomyolysis, metabolic acidosis, organ failureCirrhosis93246–Death[[5]]CHB
lactic acidosis 13086 mmol/L × 9.608 = mg/dLThe risk factors for telbivudine-induced rhabdomyolysis, hyperlactatemia, lactic acidosis , or MOF are still unclear. A previous study found telbivudine appears to cause accelerated muscle toxicity
lactic acidosis 13419 recipients, telbivudine-induced polyneuropathy/myopathy maybe due to diabetes [[19]]. When it comes to lactic acidosis or hyperlactatemia caused by telbivudine, Jin et al. found that a case with telbivudine-induced lactic
lactic acidosis 13531 acidosis or hyperlactatemia caused by telbivudine, Jin et al. found that a case with telbivudine-induced lactic acidosis had a history of hypokalemic periodic paralysis, but the relationship between the pre-existence of myopathy
lactic acidosis 13904 drinking, and had no history of diabetes mellitus [[18]]. Thus the risk factors for telbivudine-induced lactic acidosis or MOF are still ambiguous and need to be further explored. The case in this study developed severe
lactic acidosis 14056 to be further explored. The case in this study developed severe telbivudine-induced rhabdomyolysis, lactic acidosis , and MOF; the reason maybe that his elevated CK levels and rhabdomyolysis were not discovered in a timely
lactic acidosis 14321 reexamination. Although telbivudine was stopped, the rhabdomyolysis continue progressed and developed to lactic acidosis and MOF. So during the telbivudine treatment for HBV, except for detecting the possible risk factors
lactic acidosis 14492 except for detecting the possible risk factors associated with telbivudine-induced rhabdomyolysis or lactic acidosis , monitoring for muscular abnormalities, CK levels, and rhabdomyolysis is also very important for these
lactic acidosis 14672 rhabdomyolysis is also very important for these cases.Mechanisms underlying telbivudine-induced myopathy and lactic acidosis remain unclear. Whereas some studies showed that telbivudine may cause mitochondrial toxicity and dysfunction,
lactic acidosis 14832 that telbivudine may cause mitochondrial toxicity and dysfunction, which might lead to myopathy and lactic acidosis [[20]], in vitro studies indicated no effect of the drug on lactic acid production, mitochondrial DNA
lactic acidosis 15298 the case of 30-year-old man with telbivudine-induced severe side effects, including rhabdomyolysis, lactic acidosis , and MOF. His condition deteriorated rapidly after admission, with shortness of breath, muscle weakness,
lactic acidosis 15989 CRRT and methylprednisolone therapy, which played key roles in the telbivudine-induced rhabdomyolysis, lactic acidosis , and MOF.The role of glucocorticoid in the treatment of telbivudine-induced rhabdomyolysis, lactic acidosis,
lactic acidosis 16097 acidosis, and MOF.The role of glucocorticoid in the treatment of telbivudine-induced rhabdomyolysis, lactic acidosis , and MOF are unclear. In this study, we found our patient’s elevated lactate level in his blood and
lactic acidosis 16610 glucocorticoid therapy may play key roles in stabilizing telbivudine-induced severe rhabdomyolysis, lactic acidosis , and MOF. Another study found that low-dose glucocorticoid for a short period of time may help to return
lactic acidosis 17664 knowledge, the patient in this study was the first case which experienced myopathy, rhabdomyolysis, lactic acidosis , shock, and MOF during telbivudine treatment and be treated successfully.ConclusionsTelbivudine can
lactic acidosis 17853 successfully.ConclusionsTelbivudine can cause severe side effects, including myositis, neuritis, rhabdomyolysis, lactic acidosis , and even MOF. Risk of severe side effects is especially pronounced in younger male or highly active

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