Association between investigator-measured body-mass index and colorectal adenoma: a systematic review and meta-analysis of 168,201 subjects.

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hyperinsulinemia 1 endocrinologydiseases
obesity 15 endocrinologydiseases

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hyperinsulinemia 26718 and CRA [[32], [62]]. Alternatively, it has been hypothesized that insulin resistance and subsequent hyperinsulinemia induced by obesity may lead to direct mitogenic and antiapoptotic signaling by insulin or insulin-like
obesity 2723 well as Asia Pacific nations such as Japan, Korea, Singapore and Hong Kong [[3], [4]]. Overweight and obesity , defined as a body mass index (BMI) of 25–30 and ≥ 30 kg/m2, respectively, is one of the recognized
obesity 2910 is one of the recognized environmental risk factors for the development of CRC [[5]–[7]]. Whilst obesity is preventable, statistics from the World Health Organization reported that more than 1.9 billion adults
obesity 6661 neoplas* OR tumor* OR tumour* OR carcinoma* OR sarcoma* OR adenoma* OR lesion* OR polyp* OR CRC) AND obesity or overweight (body mass index OR BMI OR body size OR body weight OR intraabdominal OR overweight OR
obesity 6777 overweight (body mass index OR BMI OR body size OR body weight OR intraabdominal OR overweight OR fat OR obesity OR obese OR waist) [[32]] (Supplementary File 1). Grey literature search was performed in Grey Literature
obesity 24792 prospective cohort studies that followed-up screening subjects and examine the direct influence of obesity on CRA development [[57]]. Furthermore, the estimation of dose-response association requires at least
obesity 25217 could not be performed. From one cohort study (Sedjo et al. [[57]]), the association between CRA and obesity vs. overweight (adjusted OR 2.16, 95% CI 1.13–4.14 vs. OR 1.54, 95% CI 0.81–2.91) suggested a trend
obesity 26052 cause-and-effect relationship between BMI and CRA.The exact mechanisms of colorectal carcinogenesis induced by obesity are still not entirely clear. Our study findings reported a significant association between BMI and
obesity 26303 development of non-advanced CRA to advanced CRA, the association becomes insignificant. This implies that obesity could exert, to a larger extent, its influence on risk of adenoma, but less so on adenoma progression.
obesity 26609 polymorphism variants around the melanocortin 4 receptor gene could be associated with the co-occurrence of obesity and CRA [[32], [62]]. Alternatively, it has been hypothesized that insulin resistance and subsequent
obesity 26746 Alternatively, it has been hypothesized that insulin resistance and subsequent hyperinsulinemia induced by obesity may lead to direct mitogenic and antiapoptotic signaling by insulin or insulin-like growth factor axis
obesity 26884 and antiapoptotic signaling by insulin or insulin-like growth factor axis [[63], [64]]. Furthermore, obesity has been regarded as a condition of chronic low-grade inflammation with elevation of pro-inflammatory
obesity 27614 differentiated in this study. There is emerging evidence demonstrating that the relationship between obesity and cancer is mediated by VAT rather than SAT. Several studies have identified a unique role of VAT
obesity 28698 under-reported, where data from measurement devices usually revealed higher proportions of overweight and obesity [[68], [69]]. Hence, the true association between BMI and CRA might be biased towards lower risk. In
obesity 29932 was found to be absent in subjects of African descent. The difference in prevalence of overweight and obesity in individuals according to ethnicity might affect the comparability among studies that included screening
obesity 30390 showed that being overweight (BMI 25–30) is associated with similar risk for CRA when compared with obesity (BMI ≥ 30), and hence bring forth an alert to physicians and public health practitioners on early

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