Prioritising Causal Genes at Type 2 Diabetes Risk Loci.

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obesity 3 endocrinologydiseases

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obesity 8749 was also successfully applied to identify the causal variant and a potential disease mechanism at the obesity -associated FTO locus, a region showing the strongest genetic association in GWAS for obesity and body
obesity 8842 at the obesity-associated FTO locus, a region showing the strongest genetic association in GWAS for obesity and body mass index traits [[], []]. The proposed causal allele was shown to alter an ARID5B repressor
obesity 9049 repressor motif, leading to activation of the distant IRX3 and IRX5 in adipocyte precursor cells, and pro- obesity consequences for adipocyte thermogenesis regulation [[]•]. This work also highlights the additional

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