Postprandial lipemia: factoring in lipemic response for ranking foods for their healthiness.

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Term Occurence Count Dictionary
atorvastatin 1 endocrinologydiseasesdrugs
ciprofibrate 1 endocrinologydiseasesdrugs
gemfibrozil 1 endocrinologydiseasesdrugs
hyperinsulinemia 1 endocrinologydiseases
hypertriglyceridemia 3 endocrinologydiseases
obesity 4 endocrinologydiseases
simvastatin 2 endocrinologydiseasesdrugs
Insulin 3 endocrinologydiseasesdrugs
fenofibrate 1 endocrinologydiseasesdrugs
metabolic syndrome 3 endocrinologydiseases
type 2 diabetes mellitus 1 endocrinologydiseases
diabetes mellitus 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 26927 interventions above may be due to differences in the fat load of the meal consumed.Pathological conditions Insulin resistance and diabetesInsulin resistance increases circulating postprandial plasma triglycerides through
Insulin 26958 differences in the fat load of the meal consumed.Pathological conditionsInsulin resistance and diabetes Insulin resistance increases circulating postprandial plasma triglycerides through a series of mechanisms. Insulin
Insulin 27065 resistance increases circulating postprandial plasma triglycerides through a series of mechanisms. Insulin resistance in the adipose tissue stimulates increase in hormone sensitive lipase, increasing lipolysis
atorvastatin 18395 the triglyceride kinetics may be influenced by LDL cholesterol levels. In hyperlipidemic subjects, atorvastatin (statin) treatment has been demonstrated to improve triglyceride clearance in response to an oral fat
ciprofibrate 19079 triglycerides to some extent [[90]]. In diabetic patients treatment with fibrates (gemfibrozil and ciprofibrate ) has been shown to improve postprandial triglyceride levels [[91], [92]] and endothelial function [[92]].
fenofibrate 19709 VLDL and remnant lipoproteins [[90]]. Additionally, diabetic patients on a combined treatment with fenofibrate (fibrate) and simvastatin (statin) presented lower postprandial triglyceride iAUC compared with patients
gemfibrozil 19063 reducing circulating triglycerides to some extent [[90]]. In diabetic patients treatment with fibrates ( gemfibrozil and ciprofibrate) has been shown to improve postprandial triglyceride levels [[91], [92]] and endothelial
simvastatin 19735 lipoproteins [[90]]. Additionally, diabetic patients on a combined treatment with fenofibrate (fibrate) and simvastatin (statin) presented lower postprandial triglyceride iAUC compared with patients on a simvastatin only
simvastatin 19831 and simvastatin (statin) presented lower postprandial triglyceride iAUC compared with patients on a simvastatin only treatment [[94]].Drugs used in the management of obesity may also contribute to the management
Select Disease Character Offset Disease Term Instance
diabetes mellitus 28573 compared to healthy subjects [[131]]. Microalbuminuria is a common feature in patients with type 2 diabetes mellitus and patients with this disease have been shown to exhibit higher postprandial triglyceride levels than
hyperinsulinemia 29120 controls, following consumption of a fatty meal. Since hypertension is linked with insulin resistance, hyperinsulinemia in hypertensive patients may increase the hepatic production of VLDL, resulting in higher blood triglyceride
hypertriglyceridemia 3888 resistance [[16]] or inflammatory cell recruitment [[17]]. It has also been demonstrated that post-meal hypertriglyceridemia has adverse effects on endothelial function [[17], [18]]. The exchange of core lipids between postprandial
hypertriglyceridemia 4566 groups already at risk [[21]]. Figure 1 summarises the pathophysiological effects of postprandial hypertriglyceridemia .Fig. 1Summary of the pathophysiological effects of postprandial hypertriglyceridemia. ICAM-1, Intercellular
hypertriglyceridemia 4651 of postprandial hypertriglyceridemia.Fig. 1Summary of the pathophysiological effects of postprandial hypertriglyceridemia . ICAM-1, Intercellular Adhesion Molecule 1; IL-6, interleukin-6; IL-8, interleukin-8; NF-κB, nuclear
metabolic syndrome 19215 improve postprandial triglyceride levels [[91], [92]] and endothelial function [[92]]. In patients with metabolic syndrome , fibrates (Bezafibrate) improved remnant like lipoprotein clearance postprandially in addition to improving
metabolic syndrome 28403 high-risk population [[21]]. An exaggeration of postprandial lipemia has also been reported in people with metabolic syndrome , a pre-disposition for the development of diabetes, compared to healthy subjects [[131]]. Microalbuminuria
metabolic syndrome 32346 comparison of the effects of different food products on postprandial lipemia.Future directionsSubjects with metabolic syndrome , obesity and hypertension, among other disorders, may have normal fasting blood lipids, despite presenting
obesity 19897 iAUC compared with patients on a simvastatin only treatment [[94]].Drugs used in the management of obesity may also contribute to the management of postprandial lipemia by inhibiting fat absorption, reducing
obesity 20473 involved in food intake [[96]]. Thiazolidinedione derivatives have also been used for the management of obesity [[97]] and Metformin has been used to improve insulin sensitivity, body weight, plasma lipids and leptin
obesity 32366 different food products on postprandial lipemia.Future directionsSubjects with metabolic syndrome, obesity and hypertension, among other disorders, may have normal fasting blood lipids, despite presenting with
obesity 34707 have the potential to improve satiety and consequently reduce caloric intake for the prevention of obesity and related cardio-metabolic diseases. Developing a ranking criterion based on both glucose and lipid
type 2 diabetes mellitus 28566 diabetes, compared to healthy subjects [[131]]. Microalbuminuria is a common feature in patients with type 2 diabetes mellitus and patients with this disease have been shown to exhibit higher postprandial triglyceride levels than

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