Does hyperthyroidism worsen prognosis of thyroid carcinoma? A retrospective analysis on 2820 consecutive thyroidectomies.

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hypothyroidism 1 endocrinologydiseases
thyroid carcinoma 24 endocrinologydiseases
goiter 1 endocrinologydiseases
hyperthyroidism 10 endocrinologydiseases
hypoparathyroidism 9 endocrinologydiseases

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goiter 17005 thyroid surgery [[27]–[33]]. By the other side, patients with Grave’s disease or multinodular toxic goiter in whom no suspicion of carcinoma exists, should be treated with only total thyroidectomy.Patients with
hyperthyroidism 59 Title: Journal of Otolaryngology - Head & Neck SurgeryDoes hyperthyroidism worsen prognosis of thyroid carcinoma? A retrospective analysis on 2820 consecutive thyroidectomiesFabio
hyperthyroidism 2065 numberResearch registry n. 2670 registered 19 June 2017 (retrospectively registered).BackgroundIn the past hyperthyroidism was considered a protective factor for thyroid carcinoma [[1]]. Nevertheless, since the Fifties some
hyperthyroidism 2414 several authors [[4]–[7]] have suggested that not only thyroid carcinoma is frequently associated with hyperthyroidism , especially with Graves’ disease, but it also has an aggressive behavior. In this scenario, TSH seems
hyperthyroidism 3861 euthyroid patients were included in Group B.All the patients included in group A had received diagnosis of hyperthyroidism , defined as low serum TSH level (< 0.4 mIU/L) with high or normal (subclinic hyperthyroidism) free T4
hyperthyroidism 3954 diagnosis of hyperthyroidism, defined as low serum TSH level (< 0.4 mIU/L) with high or normal (subclinic hyperthyroidism ) free T4 and free T3 serum levels.Patients demographics, preoperative data, pathological findings, postoperative
hyperthyroidism 11900 lower in Group A (89.1% vs 96.6%; p = 0.03).DiscussionBefore 1950 few cases of association between hyperthyroidism and carcinoma were reported, so that some authors suggested that hyperthyroidism could be a cancer-protective
hyperthyroidism 11981 association between hyperthyroidism and carcinoma were reported, so that some authors suggested that hyperthyroidism could be a cancer-protective factor [[1], [9]]. Nevertheless, in the last decades several studies [[4]–[7]]
hyperthyroidism 13535 euthyroid patients. Sokal [[2]] found a 20-fold increase of thyroid carcinoma incidence in patients with hyperthyroidism . Yeh [[23]], in a large population-based cohort study, analyzed data of 1 million of patients from Taiwan’s
hyperthyroidism 13768 National Health Insurance database and reported an increased risk of head and neck cancer in patients with hyperthyroidism , especially for thyroid carcinoma.We observed in our study a high incidence of carcinoma in hyperthyroid
hyperthyroidism 14297 authors [[7], [9], [14]] have reported a high frequency of aggressive subtypes of thyroid carcinoma in hyperthyroidism , being larger, more often multicentric, locally invasive or metastatic.Belfiore [[14], [15]] described
hypoparathyroidism 1142 were hyperthyroid and 822 euthyroid. We observed, in hyperthyroid patients, a higher rate of transient hypoparathyroidism (28.1% vs 13.2%; p < 0.01) and of node metastases (12.6% vs 6.1%; p = 0.03); also local recurrence
hypoparathyroidism 4135 preoperative data, pathological findings, postoperative complications (including recurrent nerve injury and hypoparathyroidism ) and locoregional or distant recurrence were recorded.Preoperative assessmentAll the patients included
hypoparathyroidism 5424 assayed on first and second postoperative day to promptly detect hypocalcemia: in this case, diagnosis of hypoparathyroidism was confirmed in case of PTH < 10 pg/ml (normal range = 10-65 pg/ml). Drainage was usually
hypoparathyroidism 8707 outcomes and follow up (Table 2)Group A. Mean postoperative stay was 2.2 ± 0.8 days; transient hypoparathyroidism was observed in 29 (28.1%) patients and persistent in 4 (4.5%); recurrent nerve injury occurred in 2
hypoparathyroidism 9195 (days)2.2 ± 0.82.3 ± 1.20.81Follow-up (months)59.3 ± 29.2462.1 ± 19.80.77Transient hypoparathyroidism 29 (28.1%)109 (13.2%)<0.01Permanent hypoparathyroidism4 (4.5%)31 (3.7%)0.93Recurrent nerve injury2 (2.2%)14
hypoparathyroidism 9249 (months)59.3 ± 29.2462.1 ± 19.80.77Transient hypoparathyroidism29 (28.1%)109 (13.2%)<0.01Permanent hypoparathyroidism 4 (4.5%)31 (3.7%)0.93Recurrent nerve injury2 (2.2%)14 (1.7%)0.97Local recurrence5 (5.7%)21 (2.5%)0.175-year
hypoparathyroidism 9574 with at least 5 years of followupGroup B: Mean postoperative stay was 2.3 ± 1.2 days. Transient hypoparathyroidism was reported in 109 (13.2%) patients and permanent in 31 (3.7%). Transient recurrent nerve injury was
hypoparathyroidism 11379 procedure and operative time were similar between the groups. Incidence of transient postoperative hypoparathyroidism was higher in Group A (p < 0.01), whereas permanent was similar. Pathologic features were similar
hypoparathyroidism 17776 lobectomy.According to literature [[34]–[37]], we observed in our series a higher incidence of transient hypoparathyroidism in hyperthyroid patients (28.1%) than in euthyroid (13.2%; p < 0.01). Common causes of postoperative
hypothyroidism 14050 About this finding, it’s important to note that ours is a iodine-deficiency region, thus subclinic hypothyroidism , resulting in chronic increased serum TSH levels, may explain the high incidence of thyroid carcinoma
thyroid carcinoma 95 Title: Journal of Otolaryngology - Head & Neck SurgeryDoes hyperthyroidism worsen prognosis of thyroid carcinoma ? A retrospective analysis on 2820 consecutive thyroidectomiesFabio MedasErnico ErdasGian Luigi CanuAlessandro
thyroid carcinoma 460 1/2018Publication date (collection): /2018AbstractBackgroundHyperthyroidism is associated with high incidence of thyroid carcinoma ; furthermore, tumors arisen in hyperthyroid tissue show an aggressive behavior. Thyroid Stimulating
thyroid carcinoma 810 tumoral growth.MethodsWe retrospectively reviewed our series of patients who underwent thyroidectomy for thyroid carcinoma . We compared pathological features and surgical outcomes of hyperthyroid versus euthyroid patients.ResultsFrom
thyroid carcinoma 2120 (retrospectively registered).BackgroundIn the past hyperthyroidism was considered a protective factor for thyroid carcinoma [[1]]. Nevertheless, since the Fifties some studies [[2], [3]] reported a high incidence of thyroid
thyroid carcinoma 2230 carcinoma [[1]]. Nevertheless, since the Fifties some studies [[2], [3]] reported a high incidence of thyroid carcinoma in patients affected from Graves’ disease. From the ‘90s several authors [[4]–[7]] have suggested
thyroid carcinoma 2366 affected from Graves’ disease. From the ‘90s several authors [[4]–[7]] have suggested that not only thyroid carcinoma is frequently associated with hyperthyroidism, especially with Graves’ disease, but it also has an
thyroid carcinoma 3054 receptors.The aim of this retrospective study is to evaluate pathological features and clinical behavior of thyroid carcinoma arising in hyperthyroid patients, and to assess whether there are relevant differences compared with
thyroid carcinoma 3540 Surgery (University of Cagliari) between January 2007 and December 2015 with pathological diagnosis of thyroid carcinoma . Based on metabolic status, patients were divided into two groups: hyperthyroid patients, including
thyroid carcinoma 6831 underwent thyroidectomy at our department: 423 were hyperthyroid and 2398 euthyroid. The incidence of thyroid carcinoma was 20.6% in hyperthyroid patients (n = 87) and 34.3% in euthyroid (n = 822). In total, 909
thyroid carcinoma 6976 patients (n = 87) and 34.3% in euthyroid (n = 822). In total, 909 patients with diagnosis of thyroid carcinoma were included in the present study. The patients were divided into two groups in accordance with criteria
thyroid carcinoma 9908 rate of 96.6%.Pathologic data (Table 3)Group A. Mean tumor size was 2.31 ± 0.9 cm. Papillary thyroid carcinoma was reported in 59 (67.8%) patients, follicular variant of papillary carcinoma in 17 (19.5%), tall cell
thyroid carcinoma 10763 (3.4%)23 (2.8%)Follicular carcinoma5 (5.7%)110 (13.4%)Hurtle cell carcinoma3 (3.4%)35 (4.3%)PTC Papillary thyroid carcinoma Group B. Mean tumor size was 2.35 ± 1.15 cm. Papillary thyroid carcinoma was reported in 464 (56.4%)
thyroid carcinoma 10841 (3.4%)35 (4.3%)PTC Papillary thyroid carcinomaGroup B. Mean tumor size was 2.35 ± 1.15 cm. Papillary thyroid carcinoma was reported in 464 (56.4%) patients, follicular variant of papillary carcinoma in 190 (23.1%), tall
thyroid carcinoma 12135 [[1], [9]]. Nevertheless, in the last decades several studies [[4]–[7]] have reported that not only thyroid carcinoma occurs with high frequency in hyperthyroid patients, but it also has a more aggressive behavior than
thyroid carcinoma 12842 thyroid-stimulating antibodies and TSH play a key role in carcinoma’s pathogenesis.The prevalence of thyroid carcinoma in hyperthyroid patients varies widely in literature, ranging from 0.5 to over 20% [[2], [3], [9]–[22]].
thyroid carcinoma 13119 related to patients’ selection for surgery, type of surgery and geographical variation of incidence of thyroid carcinoma ; in addition, the incidence is higher in retrospective studies that only include patients who underwent
thyroid carcinoma 13391 also patients who did not underwent surgery.Anyway, most of the authors report a higher incidence of thyroid carcinoma in hyperthyroid than euthyroid patients. Sokal [[2]] found a 20-fold increase of thyroid carcinoma incidence
thyroid carcinoma 13490 thyroid carcinoma in hyperthyroid than euthyroid patients. Sokal [[2]] found a 20-fold increase of thyroid carcinoma incidence in patients with hyperthyroidism. Yeh [[23]], in a large population-based cohort study, analyzed
thyroid carcinoma 13800 reported an increased risk of head and neck cancer in patients with hyperthyroidism, especially for thyroid carcinoma .We observed in our study a high incidence of carcinoma in hyperthyroid patients (20.6%) but lower than
thyroid carcinoma 14149 hypothyroidism, resulting in chronic increased serum TSH levels, may explain the high incidence of thyroid carcinoma in euthyroid patients.Many authors [[7], [9], [14]] have reported a high frequency of aggressive subtypes
thyroid carcinoma 14276 euthyroid patients.Many authors [[7], [9], [14]] have reported a high frequency of aggressive subtypes of thyroid carcinoma in hyperthyroidism, being larger, more often multicentric, locally invasive or metastatic.Belfiore [[14],
thyroid carcinoma 14438 multicentric, locally invasive or metastatic.Belfiore [[14], [15]] described a higher incidence of thyroid carcinoma in Grave’s disease than in toxic adenoma. In addition, he found that tumor with aggressive behavior
thyroid carcinoma 15944 been reported that patients with Grave’s disease and a palpable nodule are at high risk to have a thyroid carcinoma : in these patients the incidence of thyroid carcinoma reaches 50% [[12], [14], [15], [17], [25], [26]].
thyroid carcinoma 15998 a palpable nodule are at high risk to have a thyroid carcinoma: in these patients the incidence of thyroid carcinoma reaches 50% [[12], [14], [15], [17], [25], [26]]. For these reasons, a palpable nodule found in the

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