Associations between VDR Gene Polymorphisms and Osteoporosis Risk and Bone Mineral Density in Postmenopausal Women: A systematic review and Meta-Analysis.

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osteoporosis 507 /2018AbstractResults on the relationships between vitamin D receptor (VDR) gene polymorphisms and postmenopausal osteoporosis (PMOP) susceptibility and bone mineral density (BMD) are conflicting. The aim of the study is to identify
osteoporosis 901 PMOP susceptibility. Subgroup analysis showed that VDR ApaI polymorphism significantly decreased the osteoporosis risk in Caucasian postmenopausal women. In Asian populations, VDR BsmI and VDR FokI were associated
osteoporosis 1532 Different VDR gene polymorphisms have different impacts on PMOP risk and BMD.IntroductionPostmenopausal osteoporosis (PMOP) is a common metabolic bone disorder characterized by low bone mineral density (BMD) and increased
osteoporosis 2688 issue[11]–[14]. Although previous meta-analyses reported associations between VDR polymorphisms and osteoporosis risk, the results are conflicting[9],[15],[16]. To the best of our knowledge, there lacks evidence to
osteoporosis 2906 confirm the relationship between VDR ApaI, VDR BsmI, VDR Cdx2, VDR FokI and VDR TaqI polymorphisms and osteoporosis risk in postmenopausal women. In addition, the relationship between VDR gene polymorphisms and BMD in
osteoporosis 3333 VDR gene polymorphisms (VDR ApaI, VDR BsmI, VDR Cdx2, VDR FokI and VDR TaqI) and susceptibility to osteoporosis and BMD in postmenopausal women.ResultsCharacteristics of the eligible studiesA total of 58 studies[11]–[14],[17]–[25],[27]–[71]
osteoporosis 4370 selection and inclusion process.Table 1General characteristics of studies assciated with postmenopausal osteoporosis risk.AuthorYearEthnicitySample SizeVDR ApaICaseControlCaseControlAaAAAaaaAaAAAaaaSassi et al.2015Caucasian1412311031792553631672952611590Castelán-Martínez
osteoporosis 16990 3Results of genetic models for VDR ApaI, VDR BsmI, VDR TaqI, VDR Cdx2 and VDR FokI polymorphisms and osteoporosis susceptibility in postmenopausal women.ComparisonNTest of associationModelTest of heterogeneityBegg’s
osteoporosis 28473 lumbar spine BMD in PMOP women, and in their opinion, VDR ApaI polymorphism might be a useful marker for osteoporosis screening at least in Belarusian women. VDR ApaI polymorphism is found in the non-coding region of the
osteoporosis 34208 could probably be used with other genetic markers together to identify individuals at high risk of osteoporosis . However, we could not make a certain conclusion whether VDR FokI plays a key role in BMD value in Asians
osteoporosis 35856 different ethnicities, a conclusion might be drawn that these polymorphisms may be useful markers for osteoporosis screening in certain ethnicities. Second, screening of these genetic markers may enable an early identification
osteoporosis 37459 cannot be provided to support the MR criteria.In conclusion, VDR gene polymorphisms play keys roles in osteoporosis susceptibility and BMD in postmenopausal women, although different VDR gene polymorphisms might have
osteoporosis 37623 although different VDR gene polymorphisms might have significantly different influences on the risk of osteoporosis and BMD in PMOP women with various ethnicities.Materials and MethodsLiterature searchDatabases including
osteoporosis 38111 eligible studies exploring the PMOP risk in postmenopausal women: (‘PMOP’ OR ‘Postmenopausal osteoporosis ’ OR ‘Postmenopausal’) AND (‘VDR’ OR ‘vitamin D receptor’) AND (‘polymorphism’ OR ‘single
osteoporosis 38478 women, we used the following search terms to find out eligible studies: ‘PMOP’ OR ‘Postmenopausal osteoporosis ’ OR ‘Postmenopausal’) AND (‘VDR’ OR ‘vitamin D receptor’) AND (‘polymorphism’ OR ‘single

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