Diabetes mellitus carries a risk of esophageal cancer: A meta-analysis

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Term Occurence Count Dictionary
type 2 diabetes mellitus 2 endocrinologydiseases
diabetes mellitus 7 endocrinologydiseases
hyperinsulinemia 1 endocrinologydiseases
obesity 4 endocrinologydiseases
type 1 diabetes mellitus 1 endocrinologydiseases

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diabetes mellitus 360 (collection): 9/2017Publication date (epub): 9/2017AbstractAbstractBackground:Many studies have showed that diabetes mellitus (DM) might be a risk factor for certain types of cancers. However, there are still inconsistent results
diabetes mellitus 1288 for publication bias.Results:The result showed that there was a positive correlation between type 2 diabetes mellitus (T2DM) and EC risk (RR = 1.28, 95% CI: 1.12–1.47, P < .001). Subgroup analysis based on gender
diabetes mellitus 4124 Nevertheless, many patients have not been exposed to these risk factors.In recent years, the prevalence of diabetes mellitus (DM) was significantly increased around the world.[[10],[11]] Many studies have demonstrated that DM
diabetes mellitus 4722 transduction involved in the development of cancers.[[17],[18]]In 1991, the association between type 2 diabetes mellitus (T2DM) and EC was first reported. After that, a number of studies regarding DM and EC susceptibility
diabetes mellitus 5543 databases till August 2016 with the following text word or Medical Subject Heading (MeSH) terms: (“ diabetes mellitus ” or “diabetes” or “DM” or “T2DM”) AND (“esophageal neoplasm” or “esophagus neoplasm”
diabetes mellitus 6161 ratio and 95% confidence interval (CI) in case–control studies; and patients diagnosed with type 1 diabetes mellitus (T1DM) were excluded from this analysis.Ethics statement2.3As our study was a secondary analysis regarding
diabetes mellitus 10276 publications forest plot model.Table 3Subgroup analysis of relative risks for the association between diabetes mellitus and esophageal cancer risk.When we limited the meta-analysis to the 6 studies specified for the subtypes
hyperinsulinemia 14107 apoptosis,[[38]] which could lead to cancer and cell invasion.[[39]](2)Type 2 diabetes has a correlation with hyperinsulinemia and insulin resistance. Hyperinsulinemia is associated with increased bioactive serum IGF-1 and can
obesity 3929 another potential risk factor. For EAC, gastro-esophageal reflux disease (GERD), white race, male gender, obesity , and smoking are regarded as established risk factors for EAC development.[[9]] Nevertheless, many patients
obesity 15236 precise mechanism remains unknown. An emerging hypothesis is that metabolic aberrations accompanied with obesity lead to changes in hormones and cytokines, including insulin, and serum insulin may play a role in BE
obesity 16899 etc) could inevitably play an important role in this process.[[14]] What is more, the prevalence of obesity in western countries is higher than that in eastern countries, which is a risk factor of GERD that could
obesity 17868 confounding factor is likely to be present. Unhealthy lifestyles (such as smoking and alcohol abuse) and obesity have been considered to increase the risk of cancers. Although most studies in this meta-analysis have
type 1 diabetes mellitus 6154 odds ratio and 95% confidence interval (CI) in case–control studies; and patients diagnosed with type 1 diabetes mellitus (T1DM) were excluded from this analysis.Ethics statement2.3As our study was a secondary analysis regarding
type 2 diabetes mellitus 1281 analysis was for publication bias.Results:The result showed that there was a positive correlation between type 2 diabetes mellitus (T2DM) and EC risk (RR = 1.28, 95% CI: 1.12–1.47, P < .001). Subgroup analysis based on gender
type 2 diabetes mellitus 4715 signaling transduction involved in the development of cancers.[[17],[18]]In 1991, the association between type 2 diabetes mellitus (T2DM) and EC was first reported. After that, a number of studies regarding DM and EC susceptibility

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