Dietary Anthocyanins and Insulin Resistance: When Food Becomes a Medicine.

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
hyperlipidemia 1 endocrinologydiseases
lipid metabolism disorder 1 endocrinologydiseases
obesity 23 endocrinologydiseases
rosiglitazone 1 endocrinologydiseasesdrugs
Insulin 6 endocrinologydiseasesdrugs
acarbose 1 endocrinologydiseasesdrugs
hyperglycemia 5 endocrinologydiseases
hyperinsulinemia 2 endocrinologydiseases
pioglitazone 1 endocrinologydiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Insulin 41 Title: NutrientsDietary Anthocyanins and Insulin Resistance: When Food Becomes a MedicineTarun BelwalSeyed Fazel NabaviSeyed Mohammad NabaviSolomon Habtemariam1G.B.
Insulin 691 Charham-Maritime, Kent ME4 4TB, UKPublication date (epub): 10/2017Publication date (collection): 10/2017Abstract Insulin resistance is an abnormal physiological state that occurs when insulin from pancreatic β-cells is unable
Insulin 11090 scrutinized for their potential insulin sensitizing effects in mammalian cells. 4. Dietary Anthocyanins and Insulin Sensitivity/Resistance4.1. In Vitro Protective Activity: Insulin Resistance Diabetic/Obese ConditionA
Insulin 11155 cells. 4. Dietary Anthocyanins and Insulin Sensitivity/Resistance4.1. In Vitro Protective Activity: Insulin Resistance Diabetic/Obese ConditionA summary of few selected key findings showing the enzyme inhibitory
Insulin 14772 genes and thus leads to variable functional responses [[49],[50]].4.2. In Vivo Protective Activity: Insulin Resistance Diabetic/Obese ConditionA vast numbers of in vivo protective activities of anthocyanins against
Insulin 40258 adipocyte differentiation via insulin signaling pathway[[44]]Fermented JuiceLowbush blueberry fruits Insulin sensitive cultured muscle cells and adipocytes/Stimulate glucose uptake; increase insulin sensitivity[[45]]Ethanol
acarbose 11695 [[20],[21],[22],[23],[24],[25],[26],[27],[28],[29],[30],[31],[32],[33],[34],[35],[36],[37],[38]]. This means that anthocyanins share some common anti-diabetic mechanism with drugs such as acarbose that target carbohydrate digestion in the gut thereby limiting the availability of glucose released
pioglitazone 6141 anthocyanins. Furthermore, this approach is clinically relevant, as drugs such as rosiglitazone and pioglitazone are used to treat diabetes and/or insulin resistance through their agonistic effect on peroxisome proliferator
rosiglitazone 6123 collectively called anthocyanins. Furthermore, this approach is clinically relevant, as drugs such as rosiglitazone and pioglitazone are used to treat diabetes and/or insulin resistance through their agonistic effect
Select Disease Character Offset Disease Term Instance
hyperglycemia 983 muscles and adipose tissues. The loss of insulin sensitivity is generally associated with persistent hyperglycemia (diabetes), hyperinsulinemia, fatty acids and/or lipid dysregulation which are often prevalent under
hyperglycemia 3040 related to high blood glucose [[2]]. Diabetes mellitus is a disorder characterized with persistent hyperglycemia in the blood resulting from either deficiency in insulin secretion from pancreatic β cells and/or resistance
hyperglycemia 3495 although impaired insulin secretion and β-cell death may also be evident. In both diabetes types, hyperglycemia , if not adequately managed, could lead to significant damage to vital organs but the emphasis of this
hyperglycemia 5759 achieve the normal control of glucose and other (e.g., lipids) metabolisms. Interestingly, persistent hyperglycemia (diabetes), hyperinsulinemia, fatty acids dysregulation (e.g., hyperlipidemia) can also lead to insulin
hyperglycemia 27928 cyanidin-3-O-glucoside isolated from mulberry fruit, have been well documented [[92],[139]]. On the other hand, the hyperglycemia -induced formation of advanced glycation end products that is correlated to oxidative stress associated
hyperinsulinemia 1009 tissues. The loss of insulin sensitivity is generally associated with persistent hyperglycemia (diabetes), hyperinsulinemia , fatty acids and/or lipid dysregulation which are often prevalent under obesity conditions. Hence, insulin
hyperinsulinemia 5785 of glucose and other (e.g., lipids) metabolisms. Interestingly, persistent hyperglycemia (diabetes), hyperinsulinemia , fatty acids dysregulation (e.g., hyperlipidemia) can also lead to insulin resistance [[4],[8]]. In
hyperlipidemia 5836 Interestingly, persistent hyperglycemia (diabetes), hyperinsulinemia, fatty acids dysregulation (e.g., hyperlipidemia ) can also lead to insulin resistance [[4],[8]]. In this context, this review is addressing the potential
lipid metabolism disorder 49130 NCT02689765Effect of purified anthocyanins from bilberries and black currant on insulin resistance, glucose and lipid metabolism disorder s 160 humans both male and female with type-2 diabetes of age 40–75 years taking two 80 mg anthocyanin
obesity 1098 (diabetes), hyperinsulinemia, fatty acids and/or lipid dysregulation which are often prevalent under obesity conditions. Hence, insulin sensitizers are one class of drugs currently employed to treat diabetes and
obesity 1908 of insulin resistance are presented. 1. IntroductionThe World Health Organization’s (WHO) global obesity data show that, in 2014, more than 1.9 billion adults (18 years and older) were overweight, of which
obesity 2327 either overweight or obese. This disturbing figure has also been growing with epidemic proportion with obesity number reported to be more than double from 1980 to 2014 [[1]]. Hand in hand with this fact, the global
obesity 2470 double from 1980 to 2014 [[1]]. Hand in hand with this fact, the global statistical data for the major obesity associated disease, diabetes, in 2014 were 422 million, while its prevalence has risen from 4.7% in
obesity 3685 but the emphasis of this communication lies on insulin resistance which is prevalent in T2D and/or obesity . Being the main source of energy to nearly all cells in our body, glucose concentrations in the blood,
obesity 14919 vast numbers of in vivo protective activities of anthocyanins against insulin resistance diabetic and obesity condition have been performed on insulin resistant diabetic obese animal model using either anthocyanin
obesity 15991 black rice and black soybean have also been tested in vivo against insulin resistance diabetic and obesity conditions and found to be effective (Table 2). These data along with the in vitro evidence presented
obesity 16899 have been conducted on the effect of anthocyanins against insulin resistance under diabetes and/or obesity conditions. In one study, for example, anthocyanins from bilberry (Vaccinium myrtillus) and black current
obesity 20672 tremendous potential benefit of these class of compounds in ameliorating insulin resistance and tackling T2D/ obesity observed in vitro and in vivo and that in humans will be resolved in the very near future. A lot more
obesity 21554 secretion to enhancing insulin sensitivity in vital organs. As insulin resistance is closely linked to obesity , some of the common mechanisms for anthocyanins effect on insulin resistance is summarized below.Inflammation
obesity 21735 resistance is summarized below.Inflammation has been established to be the best characterized link between obesity and insulin resistance. In fact, obesity is regarded as a state of low-grade inflammation where pro-inflammatory
obesity 21776 been established to be the best characterized link between obesity and insulin resistance. In fact, obesity is regarded as a state of low-grade inflammation where pro-inflammatory cytokines and chemokines are
obesity 24383 by regulating the PI3K/AKT pathway [[109]]. Along with inflammation, the role of oxidative stress in obesity and insulin resistance has been the subject of intense debate in recent years. The growing body of evidence
obesity 24551 debate in recent years. The growing body of evidence now suggests that ROS generation under the state of obesity is upregulated while antioxidant defenses diminish over time and this trend is even greater after the
obesity 31604 classified as an adipocytokine. The level of RBP4 in the blood and adipose tissue appears to be increased in obesity and/or diabetes. The correlation between this dysregulation and development of insulin resistance has
obesity 33894 their dietary benefits appear to be extended to enhancing insulin sensitivity that is often linked to obesity and the development of diabetes. In this regard, their multifunctional nature, expressed in our title,
obesity 34487 red.Figure 3Underlying mechanism of anthocyanins against insulin resistance associated with diabetes and/or obesity . The decrease in insulin resistance and enhancement of insulin sensitivity by anthocyanins in target
obesity 40941 resistance[[48]]nutrients-09-01111-t003_Table 3Table 3In vivo effects of anthocyanins against insulin resistance or diabetes/ obesity .Anthocyanins * Plant Name and Part UsedAnimal ModelAnti-diabetic and/or Anti-obesity ActivityReferencesJuiceAcerola
obesity 41026 resistance or diabetes/obesity.Anthocyanins * Plant Name and Part UsedAnimal ModelAnti-diabetic and/or Anti- obesity ActivityReferencesJuiceAcerola (Malpighia emarginata DC.) fruits Diabetic Wister ratsReduction in blood
obesity 42794 and lipid accumulation; increase insulin sensitivity[[59],[63],[64]]Powder BlueberriesObese ratAnti- obesity effect; increase glucose absorption[[65]]PowderBlueberryObese mice fed with high fat dietDecrease body
obesity 43723 beverageBlueberry and blackberryObese mice fed with high fat dietReduce fasting blood glucose level; prevent obesity [[70]]JuiceBlueberry and MulberryObese mice fed with high fat dietDecrease body weight gain and serum
obesity 45980 miceHypoglycemic effect[[79]]Aqueous extractMulberry (Morus alba L.) fruitsMale Syrian golden hamsterPrevent obesity ; reduce hepatic lipogenesis, body weight gain and fat accumulation[[80]]Acidified ethanol extract containing
obesity 48301 4Current clinical trials on anthocyanins as potential therapy against insulin resistance and/or diabetes/ obesity .Clinical Trial Identifier No.Objective Voluntary and DoseStatusNCT01245270Single supplement of standardized

You must be authorized to submit a review.