Enhancing Exercise Responsiveness across Prediabetes Phenotypes by Targeting Insulin Sensitivity with Nutrition.

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Term Occurence Count Dictionary
obesity 1 endocrinologydiseases
Insulin 2 endocrinologydiseasesdrugs
hyperglycemia 4 endocrinologydiseases
metabolic syndrome 2 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 112 Journal of Diabetes ResearchEnhancing Exercise Responsiveness across Prediabetes Phenotypes by Targeting Insulin Sensitivity with NutritionJulian M. GaitanArthur WeltmanSteven K. Malin1Department of Kinesiology, University
Insulin 28752 and/or delay of T2D onset.Table 1Summary of exercise plus diet effects compared with preintervention. Insulin -stimulated muscle glucose uptakeNonoxidative glucose disposalGlycogen concentrationHepatic insulin sensitivityFat
Select Disease Character Offset Disease Term Instance
hyperglycemia 2172 oversecretion of insulin from the β-cell and results in pancreatic exhaustion that leads to severe hyperglycemia [[3]].Skeletal muscle insulin resistance is primarily responsible for impaired glucose tolerance (IGT;
hyperglycemia 11779 restriction promotes insulin sensitivity [[25]], but no studies have tested this effect in subjects with hyperglycemia . Nonetheless, Holtz et al. [[26]] studied overweight, sedentary, normoglycemic adults and found that
hyperglycemia 12895 with immediately postexercise feeding. Although these findings may not generalize to individuals with hyperglycemia , as the subjects tested were fit and of normal weight, the results suggest that the timing of energy
hyperglycemia 14534 sensitivity coincided with greater reductions in skeletal muscle glycogen [[30]]. Given that chronic hyperglycemia attenuates skeletal muscle glycogen utilization during exercise [[34]–[36]], this observation of glycogen
metabolic syndrome 22307 in lowering HbA1c and body fat as well as increasing peripheral insulin sensitivity in adults with metabolic syndrome , without change in resting fat oxidation. Consistent with this observation, a low-GI food consumption
metabolic syndrome 24032 germ with high fiber) intake on clamp-derived insulin sensitivity in overweight adults with or without metabolic syndrome [[63]]. This suggests that whole-grain intake may improve skeletal muscle glucose uptake or reduce hepatic
obesity 10466 [[23]]. This suggests that in addition to exercise, calorie restriction may protect the liver from obesity -driven insulin resistance more so than training alone, despite comparable peripheral insulin sensitivity.

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