Regulation of adiposity by mTORC1.

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obesity 10 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
obesity 593 etiology to develop new therapeutic strategies. Evidence accumulated over the years indicates that obesity is associated with a marked activation in adipose tissue of the mechanistic target of rapamycin complex
obesity 1529 considered obese after reaching a body mass index (BMI) equal or higher than 30kg/m2. The prevalence of obesity has dramatically increased in the last decades attaining levels of a global pandemic,([1]) such a worrisome
obesity 1825 unhealthy dietary habits and sedentary behavior. A major concern for public health is the fact that obesity is frequently associated with the development of several chronic diseases, such as type 2 diabetes,([2])
obesity 2552 spillover of lipids, lipotoxicity and inflammatory process associated with visceral, but not subcutaneous obesity .Types of adipocytes and factors driving adipose tissue enlargementThree different types of adipocytes
obesity 7286 genes involved in lipid uptake and storage([16]) and a protection against the fat mass expansion and obesity induced by the intake of a high-fat diet.([17])Genetically modified mice displaying whole-body or tissue
obesity 7735 with whole-body deficiency of S6k1 displayed reduced fat mass, and were protected against diet-induced obesity ;([9]) such phenotypes were attributed to impaired adipogenesis.([18]) Nonetheless, a similar reduction
obesity 7882 to impaired adipogenesis.([18]) Nonetheless, a similar reduction in adiposity and protection against obesity was also seen in mice with Raptor deletion in adipocytes.([19],[20]) Conflicting molecular mechanisms
obesity 11770 level of mTORC1 activity could respond for the lipid accretion and exacerbated adiposity found upon obesity and Deptor overexpression, for example. Studies evaluating the effects of different levels of mTORC1
obesity 13271 counteract the development of these diseases. mTORC1 signaling is activated in adipose tissue upon obesity and participates in the enhanced lipid deposition and adipose tissue expansion found in this condition.
obesity 13574 adiposity may enable the development of strategies to efficiently counteract adipose tissue enlargement and obesity

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