Role of gut microbiota, bile acids and their cross-talk in the effects of bariatric surgery on obesity and type 2 diabetes.

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Term Occurence Count Dictionary
type 2 diabetes mellitus 7 endocrinologydiseases
cholic acid 10 endocrinologydiseasesdrugs
diabetes mellitus 8 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases
obesity 14 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
cholic acid 21662 enzyme in the production of bile acids. In humans, the classical pathway yields two primary bile acids, cholic acid (CA) and chenodeoxycholic acid, whereas the alternative pathway chiefly produces CA. More than 75% of
cholic acid 21693 acids. In humans, the classical pathway yields two primary bile acids, cholic acid (CA) and chenodeoxy cholic acid , whereas the alternative pathway chiefly produces CA. More than 75% of total bile acid production is
cholic acid 21902 is generally produced by the former pathway. However, primary bile acids in rodents are CA and muri cholic acid s35. When they reach the gut, primary bile acids are transformed into the secondary bile acids deoxycholic
cholic acid 22013 acids35. When they reach the gut, primary bile acids are transformed into the secondary bile acids deoxy cholic acid and lithocholic acid in humans, and ω–muricholic acids in rodents35.In addition to inducing inflammation,
cholic acid 22034 the gut, primary bile acids are transformed into the secondary bile acids deoxycholic acid and litho cholic acid in humans, and ω–muricholic acids in rodents35.In addition to inducing inflammation, gut microbiota
cholic acid 22070 transformed into the secondary bile acids deoxycholic acid and lithocholic acid in humans, and ω–muri cholic acid s in rodents35.In addition to inducing inflammation, gut microbiota plays a key role in modulating bile
cholic acid 22865 microbiota, including deconjugation and further transformation into secondary bile acids, such as CA to deoxy cholic acid or chenodeoxycholic acid to lithocholic acid, which results in an increased chemical diversity of the
cholic acid 22890 deconjugation and further transformation into secondary bile acids, such as CA to deoxycholic acid or chenodeoxy cholic acid to lithocholic acid, which results in an increased chemical diversity of the bile acid pool40. Sayin
cholic acid 22910 transformation into secondary bile acids, such as CA to deoxycholic acid or chenodeoxycholic acid to litho cholic acid , which results in an increased chemical diversity of the bile acid pool40. Sayin et al.50 showed that
cholic acid 25821 signaling and gut microbiota20.In addition to increased total bile acid levels and tauro‐ω–muri cholic acid , GB‐IL induced markedly decreased levels of FXR compared with those observed in obese mice. The same
Select Disease Character Offset Disease Term Instance
diabetes mellitus 541 HospitalShanghaiChinaPublication date (epub): 6/2017Publication date (ppub): 1/2018AbstractAbstractType 2 diabetes mellitus is becoming increasingly prevalent worldwide, and has become one of the greatest threats to global health.
diabetes mellitus 988 bypass and sleeve gastrectomy, are the most effective procedures for the treatment of obesity and type 2 diabetes mellitus worldwide. However, the specific mechanism mediating the beneficial effects of metabolic surgery has
diabetes mellitus 2342 factor for public health, as it is related to the incidence of several comorbidities, including type 2 diabetes mellitus , heart disease, stroke and certain types of cancer4. Additionally, obesity is generally considered to
diabetes mellitus 2550 considered to be a strong risk factor for diabetes5. Thus, the growing worldwide prevalence of type 2 diabetes mellitus , which is the most common type of diabetes, is associated with an increasing number of overweight and
diabetes mellitus 2901 20406. A systematic literature review showed that the obesity prevalence of adult patients with type 2 diabetes mellitus was >30% in most observational studies from different regions in the world; it even exceeded 50% in
diabetes mellitus 3668 bariatric surgery results in substantial weight loss and either improvement or remission of type 2 diabetes mellitus 11, 12, 13. As clinical data were accumulated, some versions of these procedures were ultimately abandoned
diabetes mellitus 4285 and/or bypassing some of the intestine to cause nutrient malabsorption. However, remission of type 2 diabetes mellitus has been observed after gastric bypass before the occurrence of significant weight reduction, showing
diabetes mellitus 5667 further potential contributions to the metabolic effects of weight‐loss surgery on obesity and type 2 diabetes mellitus .Role of Gut Microbiota in Bariatric SurgeryNumerous micro‐organisms exist on the surface of the skin
metabolic syndrome 6801 by a study that showed that an oral infusion of intestinal microbiota from lean donors to mice with metabolic syndrome can result in a temporary improvement of insulin sensitivity, showing a correlation between gut microbiota
obesity 137 InvestigationRole of gut microbiota, bile acids and their cross‐talk in the effects of bariatric surgery on obesity and type 2 diabetesAlternative Title: Liu et al.Haijun LiuCheng HuXueli ZhangWeiping Jia1Department
obesity 969 Roux‐en‐Y gastric bypass and sleeve gastrectomy, are the most effective procedures for the treatment of obesity and type 2 diabetes mellitus worldwide. However, the specific mechanism mediating the beneficial effects
obesity 2152 people were overweight, and more than 600 million of these individuals were obese2. The prevalence of obesity among USA adults was >33% from 2011 to 20143. Being overweight is a major risk factor for public health,
obesity 2427 including type 2 diabetes mellitus, heart disease, stroke and certain types of cancer4. Additionally, obesity is generally considered to be a strong risk factor for diabetes5. Thus, the growing worldwide prevalence
obesity 2852 this is predicted to increase to 642 million by 20406. A systematic literature review showed that the obesity prevalence of adult patients with type 2 diabetes mellitus was >30% in most observational studies from
obesity 3316 both individuals and countries6.Bariatric surgery was initially applied to the treatment of morbid obesity >60 years ago8. The procedure was originally designed to achieve and sustain weight loss, and it was
obesity 4001 gastrectomy (SG) are two of the most popular types of bariatric surgeries applied in the treatment of obesity and type 2 diabetes worldwide14.The surgery itself has led to the mechanical hypothesis that bariatric
obesity 5648 and to discuss further potential contributions to the metabolic effects of weight‐loss surgery on obesity and type 2 diabetes mellitus.Role of Gut Microbiota in Bariatric SurgeryNumerous micro‐organisms exist
obesity 6500 metabolic diseases22. Accumulating data suggest that alterations in gut microbiota are associated with obesity and diabetes, which has been attributed to an increased energy‐harvesting capacity from the diet23.
obesity 7817 microbiome of an individual25. Furthermore, compared with individuals of normal weight or with morbid obesity , obese patients who had undergone RYGB at least 6 months prior also had a substantially restructured
obesity 11259 intestinal microbes after laparoscopic‐RYGB or ‐SG by metagenomic sequencing in diabetes patients with obesity , and they observed that RYGB induced decreased Bacteroidetes, but increased Firmicutes and Actinobacteria.
obesity 16453 metabolic processes, particularly glucose and energy metabolism40. Flynn et al.41 used diet‐induced obesity mouse models and carried out biliary diversions from the gallbladder directly to the duodenum, jejunum
obesity 17240 duodenum or bile diversion to the jejunum cohorts compared with the levels in mice with diet‐induced obesity , showing that bile acids can primarily play a functional role in the hindgut41. The role of bile acids
obesity 26600 the possibility that patients with type 2 diabetes could be cured: the operation not only improves obesity , glucose tolerance and insulin sensitivity, but also opens a new avenue to gain insights into the etiology
type 2 diabetes mellitus 981 gastric bypass and sleeve gastrectomy, are the most effective procedures for the treatment of obesity and type 2 diabetes mellitus worldwide. However, the specific mechanism mediating the beneficial effects of metabolic surgery has
type 2 diabetes mellitus 2335 risk factor for public health, as it is related to the incidence of several comorbidities, including type 2 diabetes mellitus , heart disease, stroke and certain types of cancer4. Additionally, obesity is generally considered to
type 2 diabetes mellitus 2543 generally considered to be a strong risk factor for diabetes5. Thus, the growing worldwide prevalence of type 2 diabetes mellitus , which is the most common type of diabetes, is associated with an increasing number of overweight and
type 2 diabetes mellitus 2894 by 20406. A systematic literature review showed that the obesity prevalence of adult patients with type 2 diabetes mellitus was >30% in most observational studies from different regions in the world; it even exceeded 50% in
type 2 diabetes mellitus 3661 shown that bariatric surgery results in substantial weight loss and either improvement or remission of type 2 diabetes mellitus 11, 12, 13. As clinical data were accumulated, some versions of these procedures were ultimately abandoned
type 2 diabetes mellitus 4278 size and/or bypassing some of the intestine to cause nutrient malabsorption. However, remission of type 2 diabetes mellitus has been observed after gastric bypass before the occurrence of significant weight reduction, showing
type 2 diabetes mellitus 5660 discuss further potential contributions to the metabolic effects of weight‐loss surgery on obesity and type 2 diabetes mellitus .Role of Gut Microbiota in Bariatric SurgeryNumerous micro‐organisms exist on the surface of the skin

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