Prepubertal onset of slipped capital femoral epiphysis associated with hypothyroidism: a case report and literature review.

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hypogonadism 1 endocrinologydiseases
hypothyroidism 30 endocrinologydiseases
myxedema 1 endocrinologydiseases
obesity 7 endocrinologydiseases
thyroglobulin 2 endocrinologydiseasesdrugs
thyroiditis 1 endocrinologydiseases
cortisol 1 endocrinologydiseasesdrugs

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cortisol 6182 infused intravenously) showed a normal adrenocorticotropic hormone response (peak 48.4 pg/ml) and cortisol response (peak 14.4 μg/dl). After 2 months of thyroxine treatment, the patient’s thyroid levels
thyroglobulin 1108 management, primary hypothyroidism was diagnosed due to the presence of anti-thyroid peroxidase and anti- thyroglobulin antibodies. After the patient was treated for hypothyroidism, which improved his thyroid function, surgery
thyroglobulin 4643 (TSH) level of 1789 μIU/ml. The anti-thyroid peroxidase antibody level was >600 IU/ml, and the anti- thyroglobulin antibody level was 1720 IU/ml. At the age of 8 years 7 months, the bone age (assessed by the Tanner–Whitehouse
Select Disease Character Offset Disease Term Instance
hypogonadism 7345 epiphyseal closure is delayed because of the influence of an endocrine disease (e.g., hypothyroidism, hypogonadism ), however, SCFE may occur even during adulthood. Hence, it is widely recognized that endocrine disease
hypothyroidism 101 Title: BMC Endocrine DisordersPrepubertal onset of slipped capital femoral epiphysis associated with hypothyroidism : a case report and literature reviewSaori KadowakiTomohiro HoriHideki MatsumotoKaori KandaMichio OzekiYu
hypothyroidism 707 during puberty, with obesity a common risk factor. We experienced a rare case of SCFE associated with hypothyroidism in a prepubescent patient who was not obese.Case presentationThe patient was an 8-year-old boy suffering
hypothyroidism 852 was not obese.Case presentationThe patient was an 8-year-old boy suffering from bilateral SCFE with hypothyroidism . The patient’s growth had started to slow at 4 years of age, and at 8 years he was of short stature.
hypothyroidism 1023 of age, and at 8 years he was of short stature. During his evaluation for SCFE management, primary hypothyroidism was diagnosed due to the presence of anti-thyroid peroxidase and anti-thyroglobulin antibodies. After
hypothyroidism 1168 presence of anti-thyroid peroxidase and anti-thyroglobulin antibodies. After the patient was treated for hypothyroidism , which improved his thyroid function, surgery was performed for bilateral SCFE.ConclusionsAmong the
hypothyroidism 1321 surgery was performed for bilateral SCFE.ConclusionsAmong the 42 patients with SCFE associated with hypothyroidism in the literature, most SCFE occurred during puberty or in adults with delayed epiphyseal closure. Only
hypothyroidism 1598 ≤9 years old. Although being overweight or obese is common for patients with SCFE associated with hypothyroidism (76.0%), it was not observed in the present case. Persistent hypothyroidism, however, may be a risk
hypothyroidism 1674 with SCFE associated with hypothyroidism (76.0%), it was not observed in the present case. Persistent hypothyroidism , however, may be a risk factor for SCFE even before puberty and without obesity.BackgroundSlipped capital
hypothyroidism 2887 of SCFE in Japanese children is thought to be obesity.Rarely, SCFE is an important complication of hypothyroidism that often develops during childhood. We describe a case of hypothyroidism accompanied by SCFE in a
hypothyroidism 2962 important complication of hypothyroidism that often develops during childhood. We describe a case of hypothyroidism accompanied by SCFE in a prepubertal patient. We also review previously reported cases of SCFE associated
hypothyroidism 3088 by SCFE in a prepubertal patient. We also review previously reported cases of SCFE associated with hypothyroidism .Case presentationAn 8-year-old boy presented with pain in his left hip joint that had persisted for
hypothyroidism 6520 and conclusionsWe describe herein an 8-year-old patient with bilateral SCFE. He was diagnosed with hypothyroidism during the examination for possible SCFE after 4 years of slow growth. We also reviewed the literature
hypothyroidism 6668 possible SCFE after 4 years of slow growth. We also reviewed the literature for other cases of SCFE with hypothyroidism versus those with SCFE alone.An epidemiological study of 314 patients with SCFE in Japan showed that
hypothyroidism 7329 not occur. If epiphyseal closure is delayed because of the influence of an endocrine disease (e.g., hypothyroidism , hypogonadism), however, SCFE may occur even during adulthood. Hence, it is widely recognized that endocrine
hypothyroidism 7615 adulthood SCFE.In addition to our current case, we reviewed the clinical features of 42 cases of SCFE with hypothyroidism from 24 reports published after 1980 (Table 1) [[5]–[28]]. The age of onset ranged from 7 to 28 years
hypothyroidism 7797 age of onset ranged from 7 to 28 years (mean 13.5 years, median 13 years). The onset of SCFE with hypothyroidism was commonly during adolescence. Accordingly, five patients (11.9%) had disease onset at ≥18 years.
hypothyroidism 8047 including our own, had disease onset at ≤9 years of age. Thus, our case is a rare example of SCFE with hypothyroidism occurring prior to puberty.Table 1Reported cases of SCFE associated with hypothyroidismPublication year[reference]Age/SexHeightbWeightaDiseased
hypothyroidism 8135 of SCFE with hypothyroidism occurring prior to puberty.Table 1Reported cases of SCFE associated with hypothyroidism Publication year[reference]Age/SexHeightbWeightaDiseased side2004 [[5]]7/Mshort statureobese or overweightbilateralPresent
hypothyroidism 11105 indicate that obesity is a risk factor for SCFE. As shown in Table 1, among the 42 patients with SCFE and hypothyroidism , body weight data were available for only 25, of whom 19 were obese or overweight (76.0%) (defined according
hypothyroidism 11512 contributed to their increased weight. These facts suggest that obesity is also a risk factor for SCFE with hypothyroidism . Our patient was not overweight, however, and so represents a rare example of SCFE with hypothyroidism
hypothyroidism 11615 hypothyroidism. Our patient was not overweight, however, and so represents a rare example of SCFE with hypothyroidism from the viewpoint of body weight. It could also be presumed that the reports for the remaining 17 of
hypothyroidism 11985 non-obese patients would account for a relatively large proportion of those with SCFE associated with hypothyroidism .Among the 42 patients with SCFE with hypothyroidism (Table 1), height was reported for 31. Short stature
hypothyroidism 12037 large proportion of those with SCFE associated with hypothyroidism.Among the 42 patients with SCFE with hypothyroidism (Table 1), height was reported for 31. Short stature was seen in 25 patients (80.6%) (defined according
hypothyroidism 12238 (defined according to the growth charts referenced in Table 1), and 6 were of normal height. Because hypothyroidism during childhood inhibits growth, short stature indicates that hypothyroidism persists for several years
hypothyroidism 12316 normal height. Because hypothyroidism during childhood inhibits growth, short stature indicates that hypothyroidism persists for several years before the induction of SCFE. Our patient presented with a 4-year period
hypothyroidism 12470 induction of SCFE. Our patient presented with a 4-year period of reduced growth (Fig. 1). Persistent hypothyroidism may contribute to the development of SCFE.The etiology of SCFE is poorly understood. In general, it
hypothyroidism 13081 also induces inactivation of the growth hormone/insulin-like growth factor axis [[31]]. The effect of hypothyroidism on the growth plate has been observed in recent animal experiments in which swine suffering from hypothyroidism
hypothyroidism 13193 hypothyroidism on the growth plate has been observed in recent animal experiments in which swine suffering from hypothyroidism exhibited significantly decreased gene expression of proteoglycans and type X collagen. Such changes
hypothyroidism 13799 whose height is ≤10% of normal for age and sex. In our patient, SCFE was triggered by prepubertal hypothyroidism , suggesting that hypothyroidism should be recognized as an independent risk factor for the development
hypothyroidism 13831 for age and sex. In our patient, SCFE was triggered by prepubertal hypothyroidism, suggesting that hypothyroidism should be recognized as an independent risk factor for the development of SCFE.In conclusion, thyroid
myxedema 11395 National Center for Chronic Disease Prevention and Health Promotion) (Table 1). It is possible that myxedema contributed to their increased weight. These facts suggest that obesity is also a risk factor for SCFE
obesity 626 from the metaphysic through the femoral epiphyseal plate. SCFE usually occurs during puberty, with obesity a common risk factor. We experienced a rare case of SCFE associated with hypothyroidism in a prepubescent
obesity 1761 case. Persistent hypothyroidism, however, may be a risk factor for SCFE even before puberty and without obesity .BackgroundSlipped capital femoral epiphysis (SCFE) is defined as posterior and inferior slippage of
obesity 2065 epiphyseal plate (growth plate) [[1], [2]]. SCFE, a rare disease, is known to be strongly associated with obesity . Most patients develop SCFE during puberty. The majority of SCFE cases are idiopathic, although, atypically,
obesity 2834 other countries. The main cause for the increased numbers of SCFE in Japanese children is thought to be obesity .Rarely, SCFE is an important complication of hypothyroidism that often develops during childhood. We
obesity 11013 cases, and those in the ≥85th percentile accounted for 92.5% of cases [[29]]. These data indicate that obesity is a risk factor for SCFE. As shown in Table 1, among the 42 patients with SCFE and hypothyroidism,
obesity 11468 (Table 1). It is possible that myxedema contributed to their increased weight. These facts suggest that obesity is also a risk factor for SCFE with hypothyroidism. Our patient was not overweight, however, and so
obesity 12700 develop in the presence of increased shearing force on the proximal epiphysis of the femur caused by obesity when growth hormones dominate over sex hormones during puberty [[30]]. Alternatively, thyroid hormone
thyroiditis 5391 lobe of the pituitary gland caused by the overproduction of TSH was suspected. Therefore, atrophic thyroiditis was diagnosed.For SCFE treatment, the patient was admitted and kept at rest, with the lower limbs in

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