Phytosterols in the Treatment of Hypercholesterolemia and Prevention of Cardiovascular Diseases.

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Annotation Summary

Term Occurence Count Dictionary
familial hypercholesterolemia 1 endocrinologydiseases
sitosterolemia 2 endocrinologydiseases
diabetes mellitus 1 endocrinologydiseases
ezetimibe 2 endocrinologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
ezetimibe 4066 of hypercholesterolemia include statins (hydroxy-methylglutaryl-coenzyme A [HMG-CoA] reductase inhibitors), ezetimibe (a selective inhibitor of cholesterol absorption), and resins or bile acid sequesters. Statins should
ezetimibe 14905 serum cholesterol levels. These benefits have been observed in association with statins[34]-[36] and also with ezetimibe .[37],[38] The meta-analysis developed by Han et al.[36] included 15 randomized clinical trials that
Select Disease Character Offset Disease Term Instance
diabetes mellitus 2205 progression of atherosclerosis. The main risk factors for atherosclerosis include smoking, hypertension, diabetes mellitus , advanced age, family history of CVD, and dyslipidemia.[4],[5]The fundamental role of dyslipidemia -
familial hypercholesterolemia 11654 - 300 mg/dLSterols/Stanols (softgel capsule)24 weeks2.70.32McKenney et al. (2014)[31]30 adults with familial hypercholesterolemia Sterols/Stanols (softgel capsule)1.86 weeks4.3< 0.01LDL-cholesterol: low-density lipoprotein cholesterol.Recent
sitosterolemia 16105 deleterious effect of phytosterols has been largely motivated by the fact that phytosterolemia (also known as sitosterolemia ), a rare autosomal recessive disease, is characterized by a 50-fold increased circulating concentration
sitosterolemia 25735 phytosterol supplementation is contraindicated in the rare patients presenting phytosterolemia (or sitosterolemia ).[16],[67]The addition of phytosterols to industrialized food as an ingredient to reduce cholesterol

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