Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity.

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metabolic syndrome 3 endocrinologydiseases
obesity 9 endocrinologydiseases
Insulin 8 endocrinologydiseasesdrugs
diabetes mellitus 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 3256 energy expenditure, which we have recently elucidated.2. Zinc Homeostasis and Pancreatic β Cells2.1. Insulin Biosynthesis in Pancreatic β CellsPancreatic β cells are known to contain very high concentrations
Insulin 4491 essential for the appropriate synthesis of insulin, as well as its storage and structural stability [[10]]. Insulin comprises a hexamer of six insulin and two zinc molecules [[11],[12]]. The mature insulin molecule comprises
Insulin 5465 completed upon the dissociation of c-peptide, mediated by prohormone convertase (PC) dissociation [[14]]. Insulin crystallization occurs under specific conditions in insulin secretory granules, in which both insulin
Insulin 8327 gene are associated with altered risk of T2DM.3. ZnT8 Plays a Crucial Role in Glucose Homeostasis3.1. Insulin Secretory Granule of ZnT8-KO MiceZnT8 is found in the plasma membrane of insulin secretory granules
Insulin 27173 for obese diabetic patients via the manipulation of adipocyte identity.5. Involvement of Zinc in the Insulin Signaling Pathway5.1. Zinc Transporters Affect Skeletal Muscle Insulin SignalingSkeletal muscle plays
Insulin 27244 identity.5. Involvement of Zinc in the Insulin Signaling Pathway5.1. Zinc Transporters Affect Skeletal Muscle Insulin SignalingSkeletal muscle plays a key role in insulin-stimulated glucose uptake in the postprandial state.
Insulin 32915 preferentially binds to hIAPP monomer and prevents hIAPP from self-associating and aggregating.Figure 3 Insulin signaling pathway and insulin mimicking function of zinc ions. Insulin binds to the insulin receptor
Insulin 32986 self-associating and aggregating.Figure 3Insulin signaling pathway and insulin mimicking function of zinc ions. Insulin binds to the insulin receptor located in the plasma membrane in the peripheral tissues, such as liver
Select Disease Character Offset Disease Term Instance
diabetes mellitus 1564 events.1. IntroductionType 2 diabetes is now a crucial health problem in many parts of the world. Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance and pancreatic beta (β) cell dysfunction.
metabolic syndrome 1203 clarified, which indicated zinc homeostasis regulation as a possible therapeutic target for obesity and metabolic syndrome . Here we review advances in the role of zinc homeostasis in the pathophysiology of diabetes, and propose
metabolic syndrome 17701 risk of diabetes. Hence, zinc supplementation is expected to be an effective method for preventing metabolic syndrome and diabetes. A previous study analyzed the effect of zinc supplementation to prepubertal obese children
metabolic syndrome 17851 analyzed the effect of zinc supplementation to prepubertal obese children on insulin resistance and metabolic syndrome . Zinc supplementation was suggested to be a useful and safe additional intervention treatment [[56]].
obesity 427 date (epub): 2/2018Publication date (collection): 2/2018AbstractZinc deficiency is a risk factor for obesity and diabetes. However, until recently, the underlying molecular mechanisms remained unclear. The breakthrough
obesity 1191 biogenesis was clarified, which indicated zinc homeostasis regulation as a possible therapeutic target for obesity and metabolic syndrome. Here we review advances in the role of zinc homeostasis in the pathophysiology
obesity 1938 central nervous system (CNS). It is well accepted that the most accurate predictor for developing T2DM is obesity . Therefore, much attention has also been paid to the contribution of nutrients and nutrient-sensing
obesity 18062 treatment [[56]]. However, to our knowledge, the effectiveness of zinc supplementation for the treatment of obesity and diabetes has not been demonstrated in large-scale studies, particularly in adults. Therefore, it
obesity 19138 analysis is needed to examine the risks and benefits of zinc supplementation as a mean for mitigating obesity and type 2 diabetes.4.2. Association between Adipocyte Metabolism and Zinc HomeostasisObesity and its
obesity 19885 cells, including preadipocytes, endothelial cells, immune cells, and fibroblasts. During the course of obesity , adipocyte cells and stromal cells in adipose tissue change in number and characteristics. Invasion
obesity 20813 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway, and this might contribute to obesity -induced insulin resistance [[62]]. Consistent with this idea, Zip14 expression is significantly reduced
obesity 25700 not gain weight. Consistent with this idea, Zip13-KO mice showed resistance to high fat diet-induced obesity [[74]].Furthermore, both gain-of-function and loss-of-function experiments have demonstrated that the
obesity 31789 Further analyses are required toward the development of zinc transporter-mediated therapies against both obesity and diabetes.Figure 1Schematic representation of insulin clearance in WT and ZnT8-KO mice. Zinc co-secreted

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