The role of bariatric surgery to treat diabetes: current challenges and perspectives.

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Term Occurence Count Dictionary
hyperglycemia 5 endocrinologydiseases
hyperlipidemia 1 endocrinologydiseases
hypertriglyceridemia 1 endocrinologydiseases
hyperuricemia 2 endocrinologydiseases
obesity 23 endocrinologydiseases
diabetes mellitus 4 endocrinologydiseases
hyperinsulinemia 2 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases
type 2 diabetes mellitus 3 endocrinologydiseases

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diabetes mellitus 374 (collection): /2017AbstractBariatric surgery is emerging as a powerful weapon against severe obesity and type 2 diabetes mellitus (T2DM). Given its role in metabolic regulation, the gastrointestinal tract constitutes a meaningful
diabetes mellitus 2241 obesity and inadequately controlled hyperglycemia despite optimal medical treatment.BackgroundType 2 diabetes mellitus (T2DM) is associated with obesity and multiple metabolic derangements, leading to increased morbidity,
diabetes mellitus 25374 management, QOL quality of life, RYGB Roux-en-Y Gastric Bypass, SG sleeve gastrectomy, T2DM type 2 diabetes mellitus LAGB: An Australian open-label study in 60 obese patients (BMI 30–40 kg/m2) with recently diagnosed
diabetes mellitus 33763 life, RYGB Roux-en-Y Gastric Bypass, SG sleeve gastrectomy, SOS Swedish Obese Subjects, T2DM type 2 diabetes mellitus , VBG vertical banded gastroplastyThe SOS (Swedish Obese Subjects) study represents a landmark in the
hyperglycemia 2176 therapy. Surgery should also be considered in patients with class I obesity and inadequately controlled hyperglycemia despite optimal medical treatment.BackgroundType 2 diabetes mellitus (T2DM) is associated with obesity
hyperglycemia 20814 because they can have the largest improvements in metabolic control even if they do not achieve complete hyperglycemia remission. These patients may actually have to be prioritised over those who can easily be placed into
hyperglycemia 36446 control after bariatric surgery is warranted, despite initial T2DM remission, due to the existing risk of hyperglycemia recurrence.In the recently published 5-year follow-up of the STAMPEDE trial, the primary endpoint of
hyperglycemia 43884 glucose-lowering regimens, and also in patients with a BMI between 35 and 39.9 kg/m2 (grade II obesity), if hyperglycemia cannot be adequately controlled despite optimal lifestyle and medical treatment. Furthermore, metabolic
hyperglycemia 48539 despite optimal therapy, but additionally in patients with class I obesity and inadequately controlled hyperglycemia despite optimal medical treatment.In spite of the well-established role of metabolic surgery as an additional
hyperinsulinemia 39116 post-surgery [[44]]. The incidence of cardiovascular events was reduced by 33%, but only in patients with hyperinsulinemia , while BMI was not able to predict any benefit [[45]]. Low-grade systemic inflammation, which characterizes
hyperinsulinemia 39694 long-term) has been reported in both male and female populations [[49]], and patients with T2DM or hyperinsulinemia apparently benefit more. Bariatric surgery has been also associated with a reduced incidence of cancer,
hyperlipidemia 28747 RCT (Diabetes Surgery Study) in terms of cardiovascular risk factors including T2DM, hypertension and hyperlipidemia [[11]]. This study enrolled 120 obese participants with T2DM of at least 6 months’ duration and poor
hypertriglyceridemia 38885 10 years after surgery, compared to the control group [[35]]. More specifically, the rate of recovery for hypertriglyceridemia was 80%, low HDL cholesterol 73%, high LDL 72%, and hypertension 62% over a period of at least 6 years
hyperuricemia 30980 VBG, RYGB10 yearsCVD risk factors (remission/prevention)↑ recovery from T2DM, dyslipidemia, HTN and hyperuricemia , ↓ incidence of T2DM and lipid disorders after surgeryAdams et al., 2007 [[49]]N = 9949RYGB7.1 yearsTotal
hyperuricemia 38667 [[41]–[43]].Cardiovascular risk factorsThe SOS study showed that the rates of T2DM, dyslipidemia, hypertension and hyperuricemia resolution were significantly higher and the respective incidence rates were significantly lower 10 years
metabolic syndrome 3975 obesity, bariatric surgery was associated with greater weight loss, higher remission rates of T2DM and metabolic syndrome , better lipid profiles, greater improvement in quality of life, and substantial reductions in medication
obesity 355 8/2017Publication date (collection): /2017AbstractBariatric surgery is emerging as a powerful weapon against severe obesity and type 2 diabetes mellitus (T2DM). Given its role in metabolic regulation, the gastrointestinal tract
obesity 1909 recently released guidelines, bariatric surgery should be recommended in diabetic patients with class III obesity , regardless of their level of glycemic control, and patients with class II obesity with inadequately
obesity 1992 patients with class III obesity, regardless of their level of glycemic control, and patients with class II obesity with inadequately controlled T2DM despite lifestyle and optimal medical therapy. Surgery should also
obesity 2140 despite lifestyle and optimal medical therapy. Surgery should also be considered in patients with class I obesity and inadequately controlled hyperglycemia despite optimal medical treatment.BackgroundType 2 diabetes
obesity 2285 hyperglycemia despite optimal medical treatment.BackgroundType 2 diabetes mellitus (T2DM) is associated with obesity and multiple metabolic derangements, leading to increased morbidity, mortality and financial burden.
obesity 2525 efforts through lifestyle interventions are essential to prevent and deal with the parallel epidemics of obesity and T2DM, only few patients who have already developed T2DM and obesity are able to comply and accomplish
obesity 2597 with the parallel epidemics of obesity and T2DM, only few patients who have already developed T2DM and obesity are able to comply and accomplish long term weight loss and glycemic control [[1]].Given its role in
obesity 3872 meta-analysis of 11 randomised clinical trials (RCTs) comparing surgical to non-surgical treatment of morbid obesity , bariatric surgery was associated with greater weight loss, higher remission rates of T2DM and metabolic
obesity 9874 enhanced incretin effect with caloric restriction alone, and it is essentially impossible for people with obesity and diabetes to maintain this drastic restriction for a prolonged period of time.There are also other
obesity 23409 control of HbA1c, lipids and blood pressure after surgery vs. IMTCourcoulas et al., 2014 [[14]]N = 69, obesity grade I/IIRYGB, LAGB1 yearWeight loss, T2DM remissionWeight loss RYGB > LAGB>LWLI, ↑ T2DM remission
obesity 24405 conventional treatment alone, acceptable adverse event profileCourcoulas et al., 2015 [[13]]N = 69, obesity grade I/IIRYGB, LAGB3 yearsWeight loss, T2DM remissionWeight loss RYGB > LAGB>LWLI, ↑ T2DM remission
obesity 29944 short- and mid-term studies. In a three-arm single-center RCT including 69 patients with grade I and II obesity and concomitant T2DM, RYGB and LAGB were compared to an intensive lifestyle weight loss intervention
obesity 39241 BMI was not able to predict any benefit [[45]]. Low-grade systemic inflammation, which characterizes obesity and diabetes, is also improved after all bariatric operations [[46]].Survival and mortalityBariatric
obesity 40696 operations involving bowel diversion [[51]]. LAGB is effective in improving glycemia in patients with obesity and T2DM, to the degree that it causes weight loss. It is associated, however, with a greater risk of
obesity 41169 its risk-benefit profile less favourable. BPD should be primarily reserved for patients with extreme obesity (BMI >60 kg/m2) in centres with significant expertise to monitor these patients in the long term [[15]].Potential
obesity 42746 to a lifestyle intervention alone in the REDUCE trial, a prospective RCT of DBS for the treatment of obesity : 326 patients with grade I and II obesity were randomized to endoscopic DBS plus diet or sham endoscopy
obesity 42788 REDUCE trial, a prospective RCT of DBS for the treatment of obesity: 326 patients with grade I and II obesity were randomized to endoscopic DBS plus diet or sham endoscopy plus diet. The devices were extracted
obesity 43717 bariatric surgery should be recommended to treat T2DM in obese patients with a BMI ≥40 kg/m2 (grade III obesity ), regardless of glycemic control or complexity of glucose-lowering regimens, and also in patients with
obesity 43871 of glucose-lowering regimens, and also in patients with a BMI between 35 and 39.9 kg/m2 (grade II obesity ), if hyperglycemia cannot be adequately controlled despite optimal lifestyle and medical treatment.
obesity 44123 considered as an option to treat T2DM in obese patients with a BMI between 30 and 34.9 kg/m2 (grade I obesity ), if adequate glycemic control is not achieved despite maximally intensified treatment with oral or
obesity 48294 and recommendations, metabolic surgery should be recommended in appropriate candidates with class III obesity , regardless of glycemic control or glucose-lowering regimens, and in patients with class II obesity
obesity 48394 obesity, regardless of glycemic control or glucose-lowering regimens, and in patients with class II obesity with inadequately controlled T2DM despite optimal therapy, but additionally in patients with class I
obesity 48503 with inadequately controlled T2DM despite optimal therapy, but additionally in patients with class I obesity and inadequately controlled hyperglycemia despite optimal medical treatment.In spite of the well-established
type 2 diabetes mellitus 367 (collection): /2017AbstractBariatric surgery is emerging as a powerful weapon against severe obesity and type 2 diabetes mellitus (T2DM). Given its role in metabolic regulation, the gastrointestinal tract constitutes a meaningful
type 2 diabetes mellitus 25367 weight management, QOL quality of life, RYGB Roux-en-Y Gastric Bypass, SG sleeve gastrectomy, T2DM type 2 diabetes mellitus LAGB: An Australian open-label study in 60 obese patients (BMI 30–40 kg/m2) with recently diagnosed
type 2 diabetes mellitus 33756 quality of life, RYGB Roux-en-Y Gastric Bypass, SG sleeve gastrectomy, SOS Swedish Obese Subjects, T2DM type 2 diabetes mellitus , VBG vertical banded gastroplastyThe SOS (Swedish Obese Subjects) study represents a landmark in the

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