Dietary capsaicin and its anti-obesity potency: from mechanism to clinical implications.

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obesity 51 endocrinologydiseases
orlistat 1 endocrinologydiseasesdrugs
diabetes mellitus 1 endocrinologydiseases
glucose intolerance 2 endocrinologydiseases
hyperlipidemia 1 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases

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orlistat 4975 therapies and supplements are urgently needed. The second approach is pharmaceutical drugs, such as orlistat , a potent and specific inhibitor of intestinal lipases. It can reduce body weight with an average weight
Select Disease Character Offset Disease Term Instance
diabetes mellitus 2111 metabolic syndrome [[4]], a cluster of morbidities that includes hypertension, hyperlipidemia, and Type 2 diabetes mellitus (T2DM) [[5]]. It can increase the risks of developing serious health problems, such as cardiovascular
glucose intolerance 19892 0.015% capsaicin showed decreased fasting glucose, insulin, leptin concentrations, and markedly improved glucose intolerance in obese mice, accompanied with decreased TRPV-1 expression in adipose tissue, increased adiponectin
glucose intolerance 21476 experiment showed that capsaicin could counter the detrimental effects of high-fat diet, including glucose intolerance , hypercholesterolemia, and suppressed activity in BAT. These effects were mainly by increasing the expression
hyperlipidemia 2084 chronic inflammation and metabolic syndrome [[4]], a cluster of morbidities that includes hypertension, hyperlipidemia , and Type 2 diabetes mellitus (T2DM) [[5]]. It can increase the risks of developing serious health problems,
metabolic syndrome 2005 people [[2],[3]]. Obesity is a serious risk factor as it is associated with chronic inflammation and metabolic syndrome [[4]], a cluster of morbidities that includes hypertension, hyperlipidemia, and Type 2 diabetes mellitus
obesity 56 Title: Bioscience ReportsDietary capsaicin and its anti- obesity potency: from mechanism to clinical implicationsJia ZhengSheng ZhengQianyun FengQian ZhangXinhua XiaoPublication
obesity 499 the efficacy of several approaches for weight loss is limited and variable. Thus, alternative anti- obesity treatments are urgently warranted, which should be effective, safe, and widely available. Active compounds
obesity 1110 chili peppers and capsaicin consumption reduce body weight and its potential mechanisms of its anti- obesity effects. With the widespread pandemic of overweight and obesity, the development of more strategies
obesity 1174 its potential mechanisms of its anti-obesity effects. With the widespread pandemic of overweight and obesity , the development of more strategies for the treatment of obesity is urgent. Therefore, a better understanding
obesity 1239 widespread pandemic of overweight and obesity, the development of more strategies for the treatment of obesity is urgent. Therefore, a better understanding of the role and mechanism of dietary capsaicin consumption
obesity 1448 consumption and metabolic health can provide critical implications for the early prevention and treatment of obesity .IntroductionThe epidemic of obesity is a growing public health problem. The incidence of obesity has
obesity 1484 critical implications for the early prevention and treatment of obesity.IntroductionThe epidemic of obesity is a growing public health problem. The incidence of obesity has more than doubled since 1980, and has
obesity 1545 of obesity.IntroductionThe epidemic of obesity is a growing public health problem. The incidence of obesity has more than doubled since 1980, and has now reached worldwide epidemic status [[1]]. In 2014, the
obesity 1834 with 1.9 billion people were affected with overweight (body mass index (BMI) ≥25 kg/m2), and that obesity (BMI ≥30 kg/m2) affected approximately 13% with 600 million people [[2],[3]]. Obesity is a serious
obesity 2460 cancer with reduced chances of survival [[8]]. Of particular concern is the incidence of overweight and obesity in children, with an estimated one-third of children and adolescents affected in the United States and
obesity 2651 the United States and over 41 million children are overweight before reaching puberty [[2]]. As such, obesity and its related diseases yield enormous tolls at individual, public health, and economic levels. In
obesity 2861 addition, genome-wide association studies (GWAS) have revealed compelling genetic signals influencing obesity risk, and genetic polymorphism plays a major role in determining obesity [[9]]. An updated randomized
obesity 2934 genetic signals influencing obesity risk, and genetic polymorphism plays a major role in determining obesity [[9]]. An updated randomized controlled trial indicated the higher body weight and waist circumference
obesity 3119 weight and waist circumference reductions in risk carriers than in non-risk carriers of the fat mass and obesity -associated (FTO) gene across different levels of personalized nutrition [[10]]. These data signify that
obesity 3426 development of novel and personalized strategies for the early prevention and treatment of overweight and obesity is warranted.Limitations in anti-obesity approachesIt has clearly established that weight loss will
obesity 3467 strategies for the early prevention and treatment of overweight and obesity is warranted.Limitations in anti- obesity approachesIt has clearly established that weight loss will significantly diminish the complications
obesity 3578 approachesIt has clearly established that weight loss will significantly diminish the complications of obesity [[12]]. Emerging human epidemiology studies indicated that reducing body weight, with weight loss of
obesity 4157 that a combination of physical exercise and low-calorie diet is the best approach to prevent and treat obesity . However, this strategy is difficult to implement and its compliance is poor. Gupta et al. [[16]] aimed
obesity 4369 to explore treatment satisfaction associated with different weight loss methods among patients with obesity . It showed that using self-modification weight loss techniques such as diet, exercise, and weight loss
obesity 5274 lead to gastrointestinal adverse effects, liver failure, and acute kidney injury [[18]]. Other anti- obesity drugs, such as rimonabant, fenfluramine, and sibutramine, have been withdrawn from the market due to
obesity 5631 agents, such as glucagon-like peptide 1 (GLP-1) analog, liraglutide has been shown its potential anti- obesity efficacy [[19]]. But it needs to be injected subcutaneously daily. Moreover, the weight loss is limited
obesity 5830 loss is limited and it can increase the risk of pancreatitis [[20]]. Compared with aforementioned anti- obesity drugs, bariatric surgery such as Roux-en-Y gastric bypass or sleeve gastrectomy is more effective. However,
obesity 6067 invasive, relatively expensive, and its long-term effect is unclear [[21]]. Therefore, alternative anti- obesity treatments are urgently warranted, which should be effective, safe, and widely available [[15]].An overview
obesity 7346 of neurodegenerative diseases such as Alzheimer’s disease [[32]]. In addition to capsaicin as anti- obesity compounds, other types of natural products also have shown to be considered as anti-obesity compounds.
obesity 7438 as anti-obesity compounds, other types of natural products also have shown to be considered as anti- obesity compounds. Celastrol (from roots of the thunder god vine) can reduce appetite and food intake in mice
obesity 7915 caffeine, and epigallocatechin gallate) play a role in adipogenesis inhibition, thus may have anti- obesity potency [[15]]. In this review, we will focus on the less highlighted aspect, in particular how dietary
obesity 8127 chili peppers and capsaicin consumption reduce body weight and the potential mechanisms of its anti- obesity effects. Figure 1 shows the molecular structure of capsaicin isolated from chili peppers.Figure 1The
obesity 8549 revealed that the consumption of foods containing capsaicin was associated with a lower prevalence of obesity [[34]]. In one double-blind, randomized, placebo-controlled trial, it indicated that treatment of overweight
obesity 12332 non-shivering thermogenesis to maintain body temperature, and it is expected to be a therapeutic target for obesity and related metabolic disorders in humans [[41]]. It showed chili pepper affects energy expenditure
obesity 13039 studies about the weight-loss effects of capsaicin was shown Table 1.Preclinical studies about anti- obesity effects of capsaicin and its potential mechanismsCapsaicin and TRPV1 activationNumerous epidemiology
obesity 13308 transient receptor potential vanilloid 1 (TRPV1) agonist, may represent a potential strategy to treat obesity . Although it is well accepted that much of the effect is caused by stimulation of the TRPV1 receptor,
obesity 13751 and cardiovascular system [[44],[45]]. TRPV1 was deemed as a potential target for the prevention of obesity due to its effect on energy metabolism and balance [[46],[47]]. Activation of TRPV1 by capsaicin can
obesity 14700 which could subsequent suppress intestinal tumorgenesis [[51]]. Table 2Preclinical studies about anti- obesity effects of capsaicinTreatmentsSpeciesDurationMetabolic disordersPotential mechanismReference0–250
obesity 16434 SIRT-1Countered hypercholesterolemia0.01% capsaicinwild-type and TRPV1−/− mice26 weeksCountered obesity Promoted SIRT-1 expressionBaskaran et al. [[60]]Browning of WATIncreased the expression of PGC-1αFacilitated
obesity 17701 UCP-1, uncoupling protein 1; WAT, white adipose tissue.The potential mechanisms underlying the anti- obesity effects of capsaicin include: (1) increase lipid oxidation and inhibit adipogenesis; (2) activate BAT
obesity 18050 modulate the function of gastrointestinal tract and gut microbiome. The molecular mechanisms of the anti- obesity effects of capsaicin were summarized in Figure 2. In addition, we further collected most preclinical
obesity 18233 collected most preclinical studies, including in vitro studies and rodent experiments about the anti- obesity effects of capsaicin (Table 2).Figure 2Molecular mechanisms of the anti-obesity effects of capsaicin(A)
obesity 18313 experiments about the anti-obesity effects of capsaicin (Table 2).Figure 2Molecular mechanisms of the anti- obesity effects of capsaicin(A) Capsaicin can inhibit adipogenesis in preadipocyte and adipocyte by up-regulating
obesity 19230 decreased preadipocyte differentiation, proliferation, and lipogenesis have the potential to reduce obesity . Hsu et al. [[52]] demonstrated that capsaicin inhibited the expression of PPARγ, C/EBP-α, and leptin,
obesity 20712 adaptive thermogenesis and experimental studies have associated BAT activity with protection against obesity and metabolic diseases [[56]]. A review illustrated that the activity of BAT can be activated and recruited
obesity 21986 exchange ratio. All these data suggested that capsaicin is a novel strategy to counter diet-induced obesity by enhancing metabolism and energy expenditure (Table 2, Figure 2) [[59]]. Baskaran et al. showed that
obesity 22198 activation of TRPV1 channels by dietary capsaicin triggered browning of adipose tissue to counteract obesity (Table 2) [[60]]. Collectively, these observations provide evidence that capsaicin can activate and
obesity 22366 evidence that capsaicin can activate and recruit BAT, which would be a promising strategy to counter obesity .Capsaicin and its role in appetite and satietyEnergy balance requires an ability of the brain to detect
obesity 22710 circuits in the hypothalamus [[61]]. Hypothalamic endoplasmic reticulum stress occurs in individuals with obesity and is thought to induce low levels of leptin receptor signaling and play a central role in development
obesity 23275 that TRPV1 had a major role in regulating glucose metabolism and hypothalamic leptin’s effects in obesity , with hypothalamic STAT-3 activity blunted in the TRPV1 knockout mice (Figure 2). Addition of dietary
obesity 24666 in the intestinal cells and tissues (Table 2, Figure 2) [[49]]. Recent study demonstrated that anti- obesity effect of capsaicin in mice fed with high-fat diet was associated with an increase in population of
obesity 25016 protein gene Reg3g in the intestine (Table 2, Figure 2) [[69]]. These data suggested that the anti- obesity effect of capsaicin is associated with a modest modulation of the function in gastrointestinal tract
obesity 25918 a long history of use for flavoring, so it is more feasible to be utilized to treat overweight and obesity , compare with medications or other interventions with certain side effects. Dietary chili peppers supplementation
obesity 26219 capsaicin to play its protective roles in metabolic health. With the widespread pandemic of overweight and obesity , the development of more strategies for the treatment of obesity is urgent. Therefore, a better understanding
obesity 26284 widespread pandemic of overweight and obesity, the development of more strategies for the treatment of obesity is urgent. Therefore, a better understanding of the role and mechanism of dietary capsaicin consumption
obesity 26493 consumption and metabolic health can provide critical implications for the early prevention and treatment of obesity

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