Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis.

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Term Occurence Count Dictionary
diabetes mellitus 1 endocrinologydiseases
endometrial carcinoma 1 endocrinologydiseases
hyperandrogenism 1 endocrinologydiseases
obesity 9 endocrinologydiseases
polycystic ovary syndrome 3 endocrinologydiseases

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diabetes mellitus 2380 hyperandrogenism, and insulin resistance. In addition to leading to infertility, PCOS is closely associated with diabetes mellitus type 2, cardiovascular diseases and endometrial carcinoma [[1]–[3]]. It was firstly reported in 1935
endometrial carcinoma 2434 infertility, PCOS is closely associated with diabetes mellitus type 2, cardiovascular diseases and endometrial carcinoma [[1]–[3]]. It was firstly reported in 1935 by Stein et al. [[4]], but its etiology still remains ambiguous.
hyperandrogenism 2267 age, is characterized by polycystic ovary (PCO), oligomenorrhea or amenorrhea, clinical or biochemical hyperandrogenism , and insulin resistance. In addition to leading to infertility, PCOS is closely associated with diabetes
obesity 60 Title: BMC Medical GeneticsAssociation between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review
obesity 473 /2017AbstractBackgroundUp to now, numerous case-control studies have reported the associations between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome (PCOS), however, without
obesity 2866 the associations between single nucleotide polymorphism (SNP) and PCOS [[7]], such as fat mass and obesity associated (FTO) gene.The human FTO gene is located on the chromosome 16q12.2 with a wide expression
obesity 3247 2007, a genome-wide association study reported that FTO is associated with body mass index (BMI) and obesity [[7]]. Obesity is a common characteristic in PCOS patients. It is reported that more than 50% PCOS cases
obesity 3494 is reasonable to assume that FTO gene might play a role in the pathogenesis of PCOS via BMI and/or obesity . Therefore, based on this assumption, many studies have been conducted to research the associations
obesity 4690 between FTO rs9939609 polymorphism and PCOS risk. The following keywords were used: “fat mass and obesity associated gene or FTO”, “rs9939609”, “polycystic ovary syndrome or PCOS”. All researched
obesity 11838 40–80% of PCOS women are overweight or obese [[26]–[29]]. Therefore, based on the high prevalence of obesity in PCOS and the heritable of obesity [[30]], genes associated with obesity might play a role in pathogenesis
obesity 11875 obese [[26]–[29]]. Therefore, based on the high prevalence of obesity in PCOS and the heritable of obesity [[30]], genes associated with obesity might play a role in pathogenesis of PCOS such as FTO gene. Recent
obesity 11913 on the high prevalence of obesity in PCOS and the heritable of obesity [[30]], genes associated with obesity might play a role in pathogenesis of PCOS such as FTO gene. Recent years, many studies have been conducted
polycystic ovary syndrome 121 GeneticsAssociation between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome : a systematic review and meta-analysisAi Ling LiuHui Jun XieHong Yan XieJun LiuJie YinJin Song HuCui
polycystic ovary syndrome 534 the associations between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome (PCOS), however, without a consistent result. Hence we performed current systematic review and meta-analysis
polycystic ovary syndrome 4745 following keywords were used: “fat mass and obesity associated gene or FTO”, “rs9939609”, “ polycystic ovary syndrome or PCOS”. All researched articles were updated on 30 March 2015 without any language limitation. When

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