Age-related Changes in Bone Marrow Mesenchymal Stromal Cells: A Potential Impact on Osteoporosis and Osteoarthritis Development.

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osteoporosis 3 endocrinologydiseases
testosterone 2 endocrinologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
testosterone 22336 hormones. Estrogen can induce osteogenic rather than adipogenic differentiation of MSCs.[71] Conversely, testosterone promotes the proliferation of MSCs and preserves their stemness.[72] This may explain a more prominent
testosterone 25772 this could be explained by an altered balance in the systemic levels of hormones such as estrogen and testosterone . Culture-expanded MSCs from OP patients have been shown to possess lower proliferative and osteogenic
Select Disease Character Offset Disease Term Instance
osteoporosis 769 life at the level of the organism. With a rise in the elderly population, the worldwide incidence of osteoporosis (OP) and osteoarthritis (OA) has increased in the past few decades. A decline in the number and “fitness”
osteoporosis 2015 biological mechanisms that aid tissue maintenance, immunity, and health. Disorders like osteoarthritis (OA), osteoporosis (OP), Alzheimer's, and Parkinson's diseases have been associated with aging, making the life of patients
osteoporosis 27948 bone marrow; ECM = extracellular matrix; MSC = mesenchymal stromal cells; OA = osteoarthritis; OP = osteoporosis ; TGFβ = transforming growth factor β.Abdallah et al. tested the impact of serum from young (20–30

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