Dietary Composition Independent of Weight Loss in the Management of Non-Alcoholic Fatty Liver Disease.

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Term Occurence Count Dictionary
glucose intolerance 1 endocrinologydiseases
hyperinsulinemia 1 endocrinologydiseases
hyperlipidemia 1 endocrinologydiseases
metabolic syndrome 4 endocrinologydiseases
obesity 8 endocrinologydiseases

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glucose intolerance 14392 not yet been completely understood.4.2. Meat (Red Meat vs. Other)High meat intake is associated with glucose intolerance , impaired insulin sensitivity, and may increase the risk of T2D [[37],[47]]. Although T2D is accepted
hyperinsulinemia 6318 as glycogen [[24]]. Hepatic steatosis occurs when impaired insulin signaling results in compensatory hyperinsulinemia . In this situation, glucose absorption decreases in skeletal muscle providing further substrate for
hyperlipidemia 25546 evaluate the effects of prebiotic fiber on NAFLD. A review article reported that in patients with T2D and hyperlipidemia who consumed either inulin or fructooligosaccharide (FOS) supplements (prebiotic fiber), improvements
metabolic syndrome 2991 fiber and omega-3 rich food [[9],[10]]. This pattern of dietary intake can lead to obesity and the metabolic syndrome , increasing the risk for NAFLD. In addition, there is emerging evidence that a deleterious dietary composition
metabolic syndrome 4150 efficacy with or without weight loss.2. Definition of NAFLDNAFLD is a hepatic manifestation of the metabolic syndrome [[16]]. It encompasses a broad pathological spectrum of disease characterized by excessive hepatic triacylglycerol
metabolic syndrome 6668 β-oxidation [[22],[25]].3.3. Gut MicrobiomeThe gut microbiota has been implicated in obesity, diabetes, metabolic syndrome and NAFLD through effects on calorie salvage, host energy metabolism, proinflammatory signaling, and
metabolic syndrome 19679 Adherence to Mediterranean diet has also been linked to less advanced NAFLD and a lower risk of having the metabolic syndrome in this patient population [[58]]. Two randomized trials have contributed the most to the evidence for
obesity 2038 one-fourth of the adult population has NAFLD [[1],[2]]. The major established risk factors for NAFLD include obesity , insulin resistance and dyslipidemia [[3]]. The NAFLD spectrum ranges from simple liver steatosis to
obesity 2975 intake of dietary fiber and omega-3 rich food [[9],[10]]. This pattern of dietary intake can lead to obesity and the metabolic syndrome, increasing the risk for NAFLD. In addition, there is emerging evidence that
obesity 3176 evidence that a deleterious dietary composition may predispose people to NAFLD, even in the absence of obesity [[11],[12]].Lifestyle modifications involving weight loss and exercise remain the cornerstone of NAFLD
obesity 6649 and inhibits β-oxidation [[22],[25]].3.3. Gut MicrobiomeThe gut microbiota has been implicated in obesity , diabetes, metabolic syndrome and NAFLD through effects on calorie salvage, host energy metabolism,
obesity 16292 they usually follow a “Western” dietary pattern, which has been linked to hypertension, diabetes, obesity and certain cancers [[47],[51],[52]].4.3. Omega-3 Rich DietsDietary sources of omega-3 PUFAs, especially
obesity 18862 beneficial effects on the prevention of cardiovascular disease, hypertension, hypercholesterolemia, and obesity [[59],[60]]. In 2014, a small observational study explored the potential association between a Mediterranean
obesity 24302 of simple sugar. High sugar intake is associated with dyslipidemia, insulin resistance and central obesity [[78]]; (v) Higher intake of calcium and magnesium content of the DASH diet may have beneficial effects
obesity 31672 of hepatic outcomes in patients with NAFLD.5.6. ProbioticsAltered gut microbiota is associated with obesity , a risk factor for NAFLD. In animal studies, probiotics have been shown to prevent liver fibrosis [[100]].

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