Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta-regression analysis

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Insulin 2 endocrinologydiseasesdrugs
childhood obesity 1 endocrinologydiseases
metabolic syndrome 2 endocrinologydiseases
obesity 21 endocrinologydiseases

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Insulin 27918 models along with the residual heterogeneity unaccounted for in the model (the I^2 beneath each model). Insulin We obtained data from 71 (male) and 31 (female) studies that examined the effect of maternal HFD on offspring
Insulin 28418 resistance, and the use of SMD helps to compare relative rather than absolute changes in these parameters. Insulin concentrations were higher in both male and female offspring of mothers consuming a HFD (Fig. 4b,d).
Select Disease Character Offset Disease Term Instance
childhood obesity 40674 and obese mothers – there was no association in offspring from normal weight mothers 35. In humans, childhood obesity has been shown to be independently associated with maternal gestational weight gain, but we were unable
metabolic syndrome 35485 energy dense foods, which promotes hyperphagia and rapid weight gain. Although this reliably induces a metabolic syndrome type picture in exposed animals, it is impossible to control for the effects of individual dietary constituents
metabolic syndrome 38636 laboratory animals has a significant impact on the susceptibility to development of diabetes and the ‘ metabolic syndrome ’ 31, 32, 33. We found in general that mouse strains exhibited a stronger offspring metabolic phenotype
obesity 2803 61.7% of adults and 31.2% of children in the UK were overweight or obese 1. The rising prevalence of obesity is evident amongst pregnant women such that around half of women of childbearing age are now overweight
obesity 3230 offspring with both short and long term sequelae 2, 3, 4. Notably, a number of studies link maternal obesity during pregnancy with an increased risk of obesity in offspring, which persists across the lifespan
obesity 3281 3, 4. Notably, a number of studies link maternal obesity during pregnancy with an increased risk of obesity in offspring, which persists across the lifespan 5, 6, 7, 8, 9, 10, 11.Although it is difficult to separate
obesity 3427 the lifespan 5, 6, 7, 8, 9, 10, 11.Although it is difficult to separate the direct effect of maternal obesity on offspring from other environmental and genetic factors, studies have found that maternal obesity
obesity 3527 obesity on offspring from other environmental and genetic factors, studies have found that maternal obesity is an independent risk factor for high BMI in her children 7, 9, 11. Furthermore, children born to obese
obesity 4042 adulthood 14. In addition, there is a strong positive association between high childhood BMI and adult obesity 15. From a public health perspective, understanding the interactions between maternal obesity and offspring
obesity 4136 adult obesity 15. From a public health perspective, understanding the interactions between maternal obesity and offspring weight is crucial to inform strategies aimed at ameliorating the growing obesity epidemic.Epidemiological
obesity 4231 maternal obesity and offspring weight is crucial to inform strategies aimed at ameliorating the growing obesity epidemic.Epidemiological studies in humans are limited in their ability to assess the independent contribution
obesity 4362 epidemic.Epidemiological studies in humans are limited in their ability to assess the independent contribution of maternal obesity to offspring phenotype, as it is difficult to separate the effects of prenatal exposure from a shared
obesity 4606 genetic factors 16. Additionally, the extent to which changes in offspring are a consequence of maternal obesity , rather than of materno‐fetal over nutrition per se is unclear 16, although some evidence suggests
obesity 4779 16, although some evidence suggests that a maternal high fat diet (HFD) increases the likelihood of obesity in offspring irrespective of maternal weight 17. Animal models facilitate studies aimed at determining
obesity 4926 weight 17. Animal models facilitate studies aimed at determining the relative importance of maternal obesity , materno‐fetal over‐nutrition and the postnatal environment; however, significant disparities between
obesity 6856 vocabulary): (Offspring OR daughter OR daughters OR son OR sons) AND (HFD OR ‘high fat’ OR ‘induced obesity ’) AND (lactation or gestation* or maternal or ‘developmental programming’ or ‘fetal programming’).
obesity 8562 Period/4offspring.ti,ab.5daughter*.ti,ab.6son*.ti,ab.7lactation.ti,ab.8gestation*.ti,ab.9maternal.ti,ab.10exp Fats/11exp Diet, High‐Fat/12hfd.ti,ab.13‘induced obesity ’.ti,ab.14‘high fat’.ti,ab.1511 or 12 or 13 or 14 or 15161 or 2 or 3 or 4 or 8 or 9 or 10175 or
obesity 34324 lactation, the impact of gestational weight gain and the endocrine changes associated with maternal obesity . In our analysis, we did not find any clear link between gestational weight gain and the offspring outcomes
obesity 35650 impossible to control for the effects of individual dietary constituents 25. Alternatively, diet‐induced obesity models include the simple exchange of carbohydrate‐derived calories for fat‐derived calories in
obesity 36187 found maternal cafeteria‐style diets led to greater offspring body weight, whereas diet‐induced obesity was associated with increased offspring lipids and insulin concentrations. This might suggest different
obesity 40684 mothers – there was no association in offspring from normal weight mothers 35. In humans, childhood obesity has been shown to be independently associated with maternal gestational weight gain, but we were unable
obesity 43566 uncertain. Whilst there are a number of cohort‐based human studies looking at the impact of maternal obesity on offspring phenotype, the ethics of introducing dietary interventions mean it is difficult to tease
obesity 43716 introducing dietary interventions mean it is difficult to tease out the independent effects of maternal obesity , maternal diet and environmental factors on offspring. There is evidence, however, that gestational
obesity 47741 experimental design to elucidate mechanisms responsible for the increased susceptibly in humans to obesity and cardio‐metabolic risk as a result of peri‐gestational maternal diet.Conflict of interest statementNo

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