Gene-Dairy Food Interactions and Health Outcomes: A Review of Nutrigenetic Studies.

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
lactose intolerance 5 endocrinologydiseases
metabolic syndrome 5 endocrinologydiseases
obesity 18 endocrinologydiseases
osteoporosis 3 endocrinologydiseases
phenylketonuria 1 endocrinologydiseases
glucose intolerance 1 endocrinologydiseases

There are not enough annotations found in this document to create the proximity graph.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
glucose intolerance 10902 provided evidence of neutral or protective associations related to metabolic syndrome risk factors (e.g., glucose intolerance , dyslipidemia, and hypertension) and chronic diseases such as CVD and T2D [[37],[38],[39],[40],[41]].
lactose intolerance 18449 outside of the digestive or reproductive systems. A recent study in nearly 23,000 Swedish adults with lactose intolerance found a decreased risk of lung, breast, and ovarian cancers compared to individuals who were lactose
lactose intolerance 19118 effects on cancer risk. Furthermore, the study design used symptomology rather than genotype to diagnose lactose intolerance , so it is also not clear as to what percentage of individuals in this study were genetically considered
lactose intolerance 20438 consistently linked to improvements in BMD and reduced bone turnover. In agreement with this concept, lactose intolerance can increase the risk for osteoporosis and bone fractures in certain populations [[62]].Researchers
lactose intolerance 20786 that LP genotype influenced BMD and bone fractures [[27]]. The CC genotype, which is associated with lactose intolerance /lactase non-persistence was associated with the lowest hip and spine BMD measures and highest fracture
lactose intolerance 44510 osteoporosisDairy Intake Osteoporosis, bone mineral density, and fracturesLactose mal-digestion and lactose intolerance were not risk factors for osteoporosis, if calcium intake from diet and/or supplements remained sufficient.Yang
metabolic syndrome 10689 Cardiometabolic DiseaseOverweight and obesity increase the risk for cardiometabolic disorders such as metabolic syndrome , CVD, and type 2 diabetes (T2D). The majority of dairy intake studies have consistently provided evidence
metabolic syndrome 10863 intake studies have consistently provided evidence of neutral or protective associations related to metabolic syndrome risk factors (e.g., glucose intolerance, dyslipidemia, and hypertension) and chronic diseases such as
metabolic syndrome 11508 the LCT-13910 C > T polymorphism in combination with higher dairy intake could increase the risk for metabolic syndrome , but only in women [[17]]. These findings suggest that other major genetic factors such as gender can
metabolic syndrome 39354 (ENCA) in SpainMilk Intake Metabolic Syndrome risk markersLP was associated with a higher odds ratio for metabolic syndrome than lactase non-persistence after adjustment for milk intake. This relationship was stronger for women
metabolic syndrome 40090 BMI mainly in those consuming high amounts of dairy products. LP was associated with higher risk for metabolic syndrome , but this association disappeared after adjustment for BMI.Bergholdt et al., 2015. [[20]]Observational,
obesity 7446 now investigating the polygenic nature of several disease states. In fact, only a small percentage of obesity cases have been shown to be monogenic [[30]]. Rather, inherited predispositions to obesity are primarily
obesity 7537 percentage of obesity cases have been shown to be monogenic [[30]]. Rather, inherited predispositions to obesity are primarily polygenic and involve both dietary and non-dietary factors [[30],[31]]. However, if a
obesity 7885 interrogate due to its strong selective advantage and frequency of occurrence in countries with high obesity rates. In fact, several studies have found correlations between LP and higher body mass index (BMI)
obesity 9403 over 97,000 participants found no evidence linking the LP mutation and dairy intake to overweight or obesity measures [[20]]. These conflicting results on LP, dairy intake, and body weight offer further evidence
obesity 10625 relationships between genetics, dairy intake, and body weight.2.2. Cardiometabolic DiseaseOverweight and obesity increase the risk for cardiometabolic disorders such as metabolic syndrome, CVD, and type 2 diabetes
obesity 30231 PREDIMED-Valencia study results showed that the rs1466113 C > G polymorphism tracked with both dairy intake and obesity . Individuals with one or more dominant G alleles tended to have a higher BMI and consumed a greater
obesity 30429 a greater amount of dairy, while those with the CC genotype had a lower BMI, a lower odds ratio for obesity , and consumed a smaller amount of dairy. In addition to consuming less dairy, the CC group also consumed
obesity 32760 between a different VDR polymorphism (Cdx2 polymorphism), vitamin D fortified yogurt intake, and central obesity in 60 Iranian subjects with T2D [[68]]. The subjects were randomly assigned to consume either 500 mL
obesity 38992 adults of European descent from the Canary Islands Nutrition Survey (ENCA) in SpainMilk Intake BMI, obesity LP was associated with higher BMI, while lactase non-persistence was not after adjustment for milk intake.
obesity 39621 [[18]]Observational, cross-sectional940 elderly Spanish adults with high risk for CVDMilk and Dairy Intake BMI, obesity LP was associated with obesity risk. These associations were found to be significant only among those
obesity 39651 elderly Spanish adults with high risk for CVDMilk and Dairy Intake BMI, obesityLP was associated with obesity risk. These associations were found to be significant only among those consuming moderate or high lactose
obesity 40369 for an average of 5.5 years97,811 adults from the Danish general populationMilk Intake Overweight, obesity , T2D riskHigh milk intake was not associated with risk of T2D or overweight-obesity, observationally
obesity 40453 Intake Overweight, obesity, T2D riskHigh milk intake was not associated with risk of T2D or overweight- obesity , observationally or genetically via LP.Bergholdt et al., 2015. [[21]]Observational, cross-sectional
obesity 41232 average of 30 years2843 adults from the 1982 Pelotas (Southern Brazil) Birth CohortMilk Intake BMI, obesity , systolic and diastolic blood pressureLP was associated with higher BMI and higher odds of overweight-obesity.
obesity 41342 systolic and diastolic blood pressureLP was associated with higher BMI and higher odds of overweight- obesity . Milk intake was not consistently associated with changes in blood pressure. Smith et al., 2016. [[23]]Meta-analysis,
obesity 48401 and adiposity biomarkersDaily intake of vitamin D fortified doogh for 12 weeks improved the central obesity indices in T2D subjects, and the improvement was more pronounced in the carriers of the AA genotype
obesity 48758 participating in the PREDIMED–Valencia Studyrs1466113 G > C in SSTR2All food groups, including dairy BMI, obesity Homozygous subjects for the C allele had significantly lower BMI and odds ratio for obesity than G-allele
obesity 48849 dairy BMI, obesityHomozygous subjects for the C allele had significantly lower BMI and odds ratio for obesity than G-allele carriers. There were also significant differences in dairy product and protein intakes
osteoporosis 20484 reduced bone turnover. In agreement with this concept, lactose intolerance can increase the risk for osteoporosis and bone fractures in certain populations [[62]].Researchers investigating the relationships between
osteoporosis 44410 case-control453 elderly Finnish women. 52 elderly Finnish women with osteoporotic fractures. 59 controls without osteoporosis Dairy Intake Osteoporosis, bone mineral density, and fracturesLactose mal-digestion and lactose intolerance
osteoporosis 44556 mineral density, and fracturesLactose mal-digestion and lactose intolerance were not risk factors for osteoporosis , if calcium intake from diet and/or supplements remained sufficient.Yang et al., 2017. [[29]]Meta-analysis,
phenylketonuria 2757 inability to properly metabolize the amino acid phenylalanine, resulting in the life-threatening disease phenylketonuria (PKU) [[2]]. A mutation in the alcohol dehydrogenase gene leads to a reduced ability to process alcohol

You must be authorized to submit a review.