Prevention and Therapy of Type 2 Diabetes-What Is the Potential of Daily Water Intake and Its Mineral Nutrients?

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Term Occurence Count Dictionary
Insulin 10 endocrinologydiseasesdrugs
diabetes mellitus 1 endocrinologydiseases
metabolic syndrome 7 endocrinologydiseases
metformin 1 endocrinologydiseasesdrugs
obesity 1 endocrinologydiseases
type 2 diabetes mellitus 1 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
Insulin 10904 reported in [[17],[25],[29]]) of which seven calculated HOMA-IR; (Homeostatic Model Assessment for Insulin Resistance) [[18],[19],[21],[22],[23],[24],[30]]. Four of the studies additionally conducted glucose
Insulin 12858 (aspartame sweetened Cola) for six months showed no significant difference between the groups in FPG, Insulin or HOMA-IR; rather, a positive trend for diet cola. This is surprising because several meta-analyses
Insulin 13872 cola and semi-skimmed milk, both of which showed no significant difference between the groups for FPG, Insulin or HOMA-IR. The lack of a significant difference between water and cola is also surprising because two
Insulin 22249 (HOMA-IR) decreased from 6.1 to 7.0, and serum insulin concentration decreased from 13.4 mcIU to 19.9 mcIU. Insulin resistance declined up to a bicarbonate concentration of 28 mmol/L; however, it increased when 28 mmol/L
Insulin 31804 participants, magnesium administration in the form of MgCl2 increased the function of β-cells [[64]]. Insulin also influences kidney cells to increase re-absorption of magnesium. After binding of insulin to its
Insulin 36201 glucose loading < 140 mg/dL)Fasting insulin (6–25 mU/L)HOMA-IR (<2) (Homeostatic Model Assessment for Insulin Resistance)(Product of fasting insulin (µU/mL) × fasting glucose (mg/dL))/405)Glycated hemoglobin,
Insulin 39623 Cola, aspartame-sweetened1 L semi-skim milkFPGFasting insulinHOMA-IR (all SO)No sign. difference for FPG Insulin and HOMA-IR between groupsNo ITT, 13/60 drop-outs, no blinding, sign. difference for sex at baseline
Insulin 40222 300 mL/day (31 g alcohol/day), CG2: dealcoholized red wine women 230 mL/day Men 300 mL/dayFPGFasting Insulin HOMA-IR (all SO)CVRF (PO)No sign. difference for FPGInsulin and HOMA-IR between groupsNo ITT, 4/28 drop-outs,
Insulin 40282 women 230 mL/day Men 300 mL/dayFPGFasting Insulin HOMA-IR (all SO)CVRF (PO)No sign. difference for FPG Insulin and HOMA-IR between groupsNo ITT, 4/28 drop-outs, no blindingGepner et al., 2015 [[23]]RCT parallel
Insulin 41139 times per day immediately after meals for 8 weeks.150 mL chamomile tea (3 g/150 mL hot water)FPGFasting Insulin HOMA-IRHbA1cChamomile tea group sign. Decrease for HbA1c (p = 0.023), serum insulin levels (p < 0.001),
metformin 38302 diabetes HbA1c 6.5–7.2%, age 18–50 y, non-smokers, participating in a weight loss program with only metformin , Iran 250 mL tap water (not specified) per day after lunch for 24 weeks250 mL diet beverageFPGFasting
Select Disease Character Offset Disease Term Instance
diabetes mellitus 2190 improve glycemic parameters in diabetic and non-diabetic persons.1. IntroductionThe incidence of type 2 diabetes mellitus , pre-diabetes, impaired glucose tolerance and metabolic syndrome has increased considerably worldwide.
metabolic syndrome 2254 IntroductionThe incidence of type 2 diabetes mellitus, pre-diabetes, impaired glucose tolerance and metabolic syndrome has increased considerably worldwide. The global prevalence of diabetes is estimated to be 8.5%, i.e.,
metabolic syndrome 15286 beverages with fruit juice showed a trend towards better glycemic parameters and a lower incidence of metabolic syndrome than substituting it with water [[40]].Another study [[22]] found no significant effects when comparing
metabolic syndrome 23696 Animal ModelIt is known that rats receiving 10% fructose in their drinking water develop symptoms of metabolic syndrome and that the plasma glucose level increases considerably. If fructose is administered in mineral water
metabolic syndrome 24307 fructose. A review from 2016 [[46]] describes the relationship between elevated aldosterone level and both metabolic syndrome and type 2 diabetes.Sirtuin 1 (SIRT1) and peroxisome proliferator-activated receptor-gamma coactivator
metabolic syndrome 24470 peroxisome proliferator-activated receptor-gamma coactivator (PGC)1-α ) are proteins that counteract metabolic syndrome and aberrant glucose metabolism. SIRT1 positively influences multiple steps in glucose metabolism in
metabolic syndrome 25823 [[51]].In summary, these animal experiments suggest that intake of mineral water in patients with either metabolic syndrome , pre-diabetes, or type 2 diabetes might have a positive influence.Besides bicarbonate, magnesium seems
metabolic syndrome 29685 studies in a total of 24,473 participants investigated the correlation between magnesium intake and metabolic syndrome [[58]]. This study revealed that daily intake of 100 mg magnesium was associated with a risk reduction
obesity 31194 environment also contributes to development of insulin resistance and is one of the main reasons for an obesity -related elevated diabetes risk. Thus, magnesium as an anti-inflammatory ion can counteract insulin resistance
type 2 diabetes mellitus 2183 can improve glycemic parameters in diabetic and non-diabetic persons.1. IntroductionThe incidence of type 2 diabetes mellitus , pre-diabetes, impaired glucose tolerance and metabolic syndrome has increased considerably worldwide.

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