Comorbidities, complications and mortality in people of South Asian ethnicity with type 1 diabetes compared with other ethnic groups: a systematic review.

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Term Occurence Count Dictionary
diabetic retinopathy 9 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases
obesity 5 endocrinologydiseases
type 1 diabetes mellitus 3 endocrinologydiseases
type 2 diabetes mellitus 2 endocrinologydiseases
Insulin 1 endocrinologydiseasesdrugs
diabetes mellitus 6 endocrinologydiseases
diabetic ketoacidosis 1 endocrinologydiseases

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Insulin 5312 (Ovid) and EMBASE using keywords and free text. The search terms included ‘Type 1 Diabetes’, ‘ Insulin Dependent Diabetes’ and ‘South Asian’ as well as terms pertaining to ethnicity such as ‘ethnic
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diabetes mellitus 621 and macrovascular complications and mortality compared with other ethnic groups in people with type 1 diabetes mellitus (T1DM).DesignSystematic review.MethodA systematic literature search strategy was designed and carried
diabetes mellitus 2324 only.ConclusionOur analysis highlights ethnic disparity in macrovascular outcomes that is so evident for type 2 diabetes mellitus may also be present for SA patients with T1DM. We highlight the need for a large, prospective, cohort
diabetes mellitus 3236 consistently reported, and the numbers of SA in each study were small.BackgroundThe epidemiology of type 1 diabetes mellitus (T1DM) in South Asians (SA) is poorly understood. Its effects on metabolic control, diabetic complication
diabetes mellitus 3596 of obesity and obesity-related diseases including insulin resistance, the metabolic syndrome, type 2 diabetes mellitus (T2DM) and coronary heart disease.[1]T2DM is two to three times more common in SA than in the WE population
diabetes mellitus 20704 A1c; HDL, high-density lipoprotein;eGFR, estimated glomerular filtration rate; IDDM, insulin-dependent diabetes mellitus ; LDL, low-density lipoprotein;M1, maculopathy; NCH, New Cross Hospital;P1, macular laser;QEH, Queen
diabetes mellitus 21154 Algorithm;SMR, standardised mortality ratio;STDR, sight-threatening diabetic retinopathy; T1DM, type 1 diabetes mellitus ; TIA, transient ischaemic attack; WE, white European.*p Value <0.05.Table 2Summary of findingsFindings
diabetic ketoacidosis 4216 in the outcomes of children with T1DM with black participants having higher mean HbA1c levels, more diabetic ketoacidosis and severe hypoglycaemic events compared with white or Hispanic participants. A recent systematic review[6]
diabetic retinopathy 18103 London)WE: 2628 African: 344 SA: 120Mean age of T1DM population: 39.4 years2008– 2009Ethnic groupAny diabetic retinopathy WE African South Asian Any maculopathy (M1)WE African SA CSMO (M1P1)WE African SA STDR (R2 or R3 or M1P1)WE
diabetic retinopathy 20560 BMI, body mass index; CSMO, clinically significant macular oedema;CVD, cardiovascular disease; DR, diabetic retinopathy ; HbA1c, haemoglobin A1c; HDL, high-density lipoprotein;eGFR, estimated glomerular filtration rate; IDDM,
diabetic retinopathy 20881 Cross Hospital;P1, macular laser;QEH, Queen Elizabeth Hospital; R1, mild to moderate non-proliferative diabetic retinopathy ; R2, preproliferative diabetic retinopathy; R3, proliferative diabetic retinopathy; SA, South Asian;
diabetic retinopathy 20924 Elizabeth Hospital; R1, mild to moderate non-proliferative diabetic retinopathy; R2, preproliferative diabetic retinopathy ; R3, proliferative diabetic retinopathy; SA, South Asian; SANGRA, South Asian Names and Group Recognition
diabetic retinopathy 20964 non-proliferative diabetic retinopathy; R2, preproliferative diabetic retinopathy; R3, proliferative diabetic retinopathy ; SA, South Asian; SANGRA, South Asian Names and Group Recognition Algorithm;SMR, standardised mortality
diabetic retinopathy 21119 Asian Names and Group Recognition Algorithm;SMR, standardised mortality ratio;STDR, sight-threatening diabetic retinopathy ; T1DM, type 1 diabetes mellitus; TIA, transient ischaemic attack; WE, white European.*p Value <0.05.Table
diabetic retinopathy 30137 (11.2% (5.4% to 16.9%) vs 6.5% (5.6% to 7.4%) vs 10.0% (6.7% to 13.3%), respectively), sight threatening diabetic retinopathy (17.5% (10.6% to 24.3%) vs 12.1% (10.9% to 13.3%) vs 15.9% (11.8% to 20.0%), respectively) and any diabetic
diabetic retinopathy 30257 (17.5% (10.6% to 24.3%) vs 12.1% (10.9% to 13.3%) vs 15.9% (11.8% to 20.0%), respectively) and any diabetic retinopathy (54.0% (44.8% to 63.2%) vs 55.0% (53.2% to 56.9%) vs 42.8% (37.3% to 48.3%), respectively).Thomas et
diabetic retinopathy 30459 respectively).Thomas et al,[15] in South Africa, reported that SA (n=118) were at increased risk of any diabetic retinopathy (OR 2.02, 95% CI 1.23 to 3.29) when compared with WE (n=1247), after adjustment for age at diagnosis,
metabolic syndrome 3569 (WE) for the development of obesity and obesity-related diseases including insulin resistance, the metabolic syndrome , type 2 diabetes mellitus (T2DM) and coronary heart disease.[1]T2DM is two to three times more common
obesity 3498 pathogenesis has yet to be explored. SA are at higher risk than white Europeans (WE) for the development of obesity and obesity-related diseases including insulin resistance, the metabolic syndrome, type 2 diabetes mellitus
obesity 3510 to be explored. SA are at higher risk than white Europeans (WE) for the development of obesity and obesity -related diseases including insulin resistance, the metabolic syndrome, type 2 diabetes mellitus (T2DM)
obesity 11588 T1DMChildren coded as T1DM in a centre in Leicestershire—no diagnostic criteria included MethodRates of obesity /overweight in WE and SA groups and to correlate these with age, duration of diagnosis, daily insulin
obesity 12259 Caucasian/SA) Obesity in childrenNo statistically significant differences noted in the rates of overweight or obesity between white Caucasian and SA children at any age grouping.Asmal et al[16] (1981)South AfricaCross-sectional
obesity 22681 al[10] also in the UK showed no statistically significant differences in the rates of overweight or obesity between WE (n=112) and SA (n=38) children with T1DM at any age grouping.Brabarupan et al[12] in the
type 1 diabetes mellitus 614 microvascular and macrovascular complications and mortality compared with other ethnic groups in people with type 1 diabetes mellitus (T1DM).DesignSystematic review.MethodA systematic literature search strategy was designed and carried
type 1 diabetes mellitus 3229 consistently reported, and the numbers of SA in each study were small.BackgroundThe epidemiology of type 1 diabetes mellitus (T1DM) in South Asians (SA) is poorly understood. Its effects on metabolic control, diabetic complication
type 1 diabetes mellitus 21147 Recognition Algorithm;SMR, standardised mortality ratio;STDR, sight-threatening diabetic retinopathy; T1DM, type 1 diabetes mellitus ; TIA, transient ischaemic attack; WE, white European.*p Value <0.05.Table 2Summary of findingsFindings
type 2 diabetes mellitus 2317 only.ConclusionOur analysis highlights ethnic disparity in macrovascular outcomes that is so evident for type 2 diabetes mellitus may also be present for SA patients with T1DM. We highlight the need for a large, prospective, cohort
type 2 diabetes mellitus 3589 development of obesity and obesity-related diseases including insulin resistance, the metabolic syndrome, type 2 diabetes mellitus (T2DM) and coronary heart disease.[1]T2DM is two to three times more common in SA than in the WE population

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