Obesity and Asthma: A Missing Link.

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
childhood obesity 1 endocrinologydiseases
metabolic syndrome 6 endocrinologydiseases
obesity 48 endocrinologydiseases

There are not enough annotations found in this document to create the proximity graph.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
childhood obesity 9975 early-onset obese asthmatics [[20]].There is a clear association between obesity and asthma, and probably childhood obesity antedates the onset of asthma. However, more studies that clarify the characteristics of the two described
metabolic syndrome 18373 among others [[36]]. Obesity is an important risk factor for insulin resistance syndrome, also known as metabolic syndrome , a complex disorder comprised by a cluster of factors that include hypertension, altered energy metabolism,
metabolic syndrome 18622 inflammation. Positive associations with lung function impairment have been described for components of the metabolic syndrome [[37]]. In postmenopausal women, the incidence of metabolic syndrome was similar for asthma and control
metabolic syndrome 18691 described for components of the metabolic syndrome [[37]]. In postmenopausal women, the incidence of metabolic syndrome was similar for asthma and control groups, but insulin resistance was significantly higher in asthma
metabolic syndrome 19156 capacity (FVC) ratio, indicating airway obstruction as compared to patients who were obese without metabolic syndrome [[37]]. Accordingly, the authors suggested that the presence of metabolic syndrome may influence lung
metabolic syndrome 19239 were obese without metabolic syndrome [[37]]. Accordingly, the authors suggested that the presence of metabolic syndrome may influence lung function impairment through the induction of systemic inflammation, particularly
metabolic syndrome 28403 bile acids. The activation of bile acid-mediated signaling has been associated with an improvement in metabolic syndrome s and enhanced control of inflammation. Bile acids inhibit Nod-like receptor family pyrin domain containing
obesity 1497 prevalence of asthma is higher in obese individuals. Recently, two major phenotypes of asthma with obesity have been described: one phenotype of early-onset asthma that is aggravated by obesity, and a second
obesity 1584 asthma with obesity have been described: one phenotype of early-onset asthma that is aggravated by obesity , and a second phenotype of later-onset asthma that predominantly affects women. Systemic inflammation
obesity 1833 expansion of the adipose tissue, have been proposed as the main reasons for the association between obesity and asthma. However, the mechanisms involved are not yet fully understood. Moreover, it has also been
obesity 2174 is an important factor in the development of the immune system, and can be considered a link between obesity and asthma. In the obese state, higher lipopolysaccharide (LPS) serum levels as a consequence of a microbiota
obesity 2571 acid (SCFA) levels. The main objective of this review is to summarize the principal findings that link obesity and asthma.1. IntroductionObesity is considered one the most important public health problems of the
obesity 3247 designated by an increased body mass index (BMI) and by systemic low-grade inflammation. In addition, obesity is associated with the development of type 2 diabetes and with cardiovascular and non-alcoholic fatty
obesity 4468 reactivity [[5]].In 1999, Camargo et al. [[6]] described for the first time the relationship between obesity and asthma. Since then, a huge number of studies have demonstrated the risk of asthma and associated
obesity 5104 an allergic early-onset disease and a non-allergic late-onset disease [[9]]. The mechanisms linking obesity and asthma are poorly understood. Genetics, lifestyle (diet, physical activity), and early exposure
obesity 5695 [[10],[11]]. Among these factors, leptin and adiponectin have been proposed as key molecules linking obesity and asthmatic conditions. The adipose tissue is comprised of different kinds of cells, among which the
obesity 5849 is comprised of different kinds of cells, among which the immune cells have an important role in the obesity -related low-grade inflammatory state [[11]]. On the other hand, the hygiene hypothesis states that exposure
obesity 6453 intestinal microbiota has been associated with a number of human diseases, such as autoimmune diseases, obesity , and asthma. In the obese state, higher lipopolysaccharide (LPS) serum levels because of microbiota
obesity 6856 acids.Overall, the aim of the present work is to carry out a revision of the scientific evidence on the obesity -asthma relationship, and to gain a better understanding of the underlying mechanisms and the putative
obesity 7939 Global Initiative for Asthma (GINA) criteria, for patients with uncontrolled asthma and with moderate obesity , weight loss was related with enhancements in asthma control. This result was accompanied by increased
obesity 8259 [[18]]. Moreover, this study also suggested that poor asthma control is, at least in part, related to obesity -associated factors. It is important to highlight that the group of patients was formed primarily of
obesity 8387 It is important to highlight that the group of patients was formed primarily of women with moderate obesity and early-onset severe asthma [[18]].Although there is a clear relationship between obesity and asthma,
obesity 8479 moderate obesity and early-onset severe asthma [[18]].Although there is a clear relationship between obesity and asthma, there are a number of subjects who are obese with a misdiagnosed asthma. The main difference
obesity 8675 main difference found between misdiagnosed asthma subjects and control subjects, both of them with obesity , was a higher perception of dyspnea during bronchial challenge and exercise [[18]]. Moreover, in subjects
obesity 8997 peak ventilatory equivalent of CO2, and serum levels of IL-6 and IL-1β [[19]].The connection between obesity and asthma is so stunning that subjects who are obese with asthma are considered a new asthma phenotype.
obesity 9269 described: an early-onset atopic asthma Th2-high, where allergic asthma is complicated by the presence of obesity , and a late-onset non-atopic asthma Th2-low, occurring preferably in women and where the development
obesity 9408 asthma Th2-low, occurring preferably in women and where the development of asthma is a consequence of obesity [[20]]. In the early-onset phenotype, obese asthmatics have a history of atopy, increased airway obstruction,
obesity 9942 exacerbations compared with early-onset obese asthmatics [[20]].There is a clear association between obesity and asthma, and probably childhood obesity antedates the onset of asthma. However, more studies that
obesity 9985 obese asthmatics [[20]].There is a clear association between obesity and asthma, and probably childhood obesity antedates the onset of asthma. However, more studies that clarify the characteristics of the two described
obesity 12954 hyper-reactivity have been reported in obese patients, and have been suggested as possible mechanisms linking obesity and asthma [[26]]. In mice without asthma, it was found that AHR or eosinophilic inflammation in lung
obesity 13092 without asthma, it was found that AHR or eosinophilic inflammation in lung tissue was not augmented by obesity (diet induced) per se [[26]]. However, in atopic asthmatic children and adolescents, obesity has been
obesity 13185 augmented by obesity (diet induced) per se [[26]]. However, in atopic asthmatic children and adolescents, obesity has been associated with increased serum leptin and tumor necrosis factor alpha (TNF-α) levels that
obesity 15567 reported [[22]]. All of these observations point to an important role for leptin in asthma-associated obesity .Adiponectin is another important adipokine secreted by the adipocytes, levels of which have been reported
obesity 17848 resistin:adiponectin ratio [[35]].To summarize, low-grade systemic inflammation is one possible mechanism linking obesity and asthma, but is unlikely to fully explain the obesity-asthma association, although TNF-α, IL-6,
obesity 17905 inflammation is one possible mechanism linking obesity and asthma, but is unlikely to fully explain the obesity -asthma association, although TNF-α, IL-6, C-reactive protein (CRP), circulating neurotransmitter neuropeptide
obesity 18163 been independently associated with asthma prevalence [[36]]. Therefore, it has been proposed that the obesity -asthma relationship is more likely to be mediated by other factors, which include type 2 diabetes among
obesity 19779 mediated by insulin resistance [[39]]. Hence, type 2 diabetes and the chronic inflammation related to obesity are associated with an increase in cellular expression and plasma concentrations of mediators involved
obesity 21135 patients who are obese asthmatics [[42]].Finally, although there is growing evidence that designated obesity -related inflammation and secreted adipokines are possible mechanisms linking obesity and asthma, more
obesity 21220 that designated obesity-related inflammation and secreted adipokines are possible mechanisms linking obesity and asthma, more studies are needed to allow us to elucidate the underlying mechanisms.2.3. Other ProteinsAdipokines
obesity 21484 tissue are not the only proteins that have emerged as key molecules in the development of asthma and obesity . Chitinase-3-like-1 (Chi3l1, YKL-40) a glycoprotein member of the glycosyl hydrolase 18 family, has
obesity 21639 glycoprotein member of the glycosyl hydrolase 18 family, has been shown to play an important role in asthma- obesity development [[43]]. Using animal models of asthma and obesity, Ahangari and collaborators demonstrated
obesity 21701 shown to play an important role in asthma-obesity development [[43]]. Using animal models of asthma and obesity , Ahangari and collaborators demonstrated that a high fat diet and Th2 inflammation induce Chi3l1 in
obesity 22201 and lung function [[43]]. In addition, higher Chi3l1 levels (168 ± 71.5 ng/mL) were associated with obesity -related asthma than with early-onset atopic and late-onset non-atopic phenotypes (80.62 ± 46.9 and
obesity 23416 increase in the evidence of associations between the gut microbiota’s dysbiosis with diseases such as obesity and asthma [[48]]. Bacterial colonization is influenced by many factors, such as infant diet, mode of
obesity 26386 influence the severity of allergic inflammation [[56]]. Similarly, associations have been found between obesity and altered profiles of fecal SCFAs that could not be explained by microbial profiling alone. The production
obesity 26584 alone. The production of SCFAs by the gut microbiota has been related to the development of asthma and obesity . SCFAs have been shown to be involved in different metabolic processes, such as the suppression of appetite,
obesity 29818 Bethesda, MD, USA) over the last 5 years, using the following MeSH terms (Medical Subject Headings): “ obesity ” and “asthma” combined with “adipokines”, “phenotype”, “gastrointestinal microbiome”,
obesity 30185 Additionally, previous original articles and reviews focusing on epigenetics and microbiota in asthma and obesity were carefully examined, together with papers describing the role of SCFAs, LPS, and bile acids in obesity
obesity 30292 were carefully examined, together with papers describing the role of SCFAs, LPS, and bile acids in obesity and asthma. A total of 183 articles were obtained, from which 46 were selected.4. ConclusionsIn the
obesity 30505 present review, we provided an overview of the potential mechanisms linking to the related conditions of obesity and asthma. A schematic representation of the linking mechanism between obesity and asthma is shown
obesity 30585 related conditions of obesity and asthma. A schematic representation of the linking mechanism between obesity and asthma is shown in Figure 2.Two obesity-asthma phenotypes have been described: early-onset atopic
obesity 30629 schematic representation of the linking mechanism between obesity and asthma is shown in Figure 2.Two obesity -asthma phenotypes have been described: early-onset atopic asthma and late-onset nonatopic asthma. Mechanical,
obesity 30992 important player in both conditions. Adipose tissue secretes adipokines and cytokines that contribute to obesity -related low-grade inflammation, and might influence asthma development. Additionally, there has been
obesity 32474 such as next-generation sequencing, metabolomics, and exosome studies.Figure 1Causes and effects of obesity .Figure 2A schematic representation of the potential linking mechanisms between obesity and asthma. SCFAs:
obesity 32561 and effects of obesity.Figure 2A schematic representation of the potential linking mechanisms between obesity and asthma. SCFAs: short-chain fatty acids; LPS: lipopolysaccharide. Beige color indicates adipose tissue

You must be authorized to submit a review.